DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and flii

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001244075.1	Gene:	flii / 560281	ZFINID:	ZDB-GENE-071212-3	Length:	1259	Species:	Danio rerio

Alignment Length:	913	Identity:	200/913 - (21%)
Similarity:	332/913 - (36%)	Gaps:	263/913 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEI 72
            |||.|               .||.: :...:|..|.|:...:..||:....|.:|..|.:|.|.:
Zfish    20 FKGGN---------------FPEHV-KSMTSLRWLKLNRTGLCYLPEELASLQKLEHLSVSHNSL 68

  Fly    73 GRLPPDIQNFENLVELDVSRNDIPD--IPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLG 135
            ..|..::.:..||..:....|::.:  :||||..|..|.|.|.|.|.:.::|......:|:.||.
Zfish    69 TTLHGELSSLPNLRAVVARANNLKNSGVPDDIFQLDDLSVLDLSHNQLTEIPRDLENSRNMLVLN 133

  Fly   136 LNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGL 200
            |:..|:..:|      .||                ...||.|..|||.||.::.|||.:..|..|
Zfish   134 LSHNSIDNIP------NQL----------------FINLTDLLYLDLSDNNLDSLPPQMRRLVHL 176

  Fly   201 HELWLDHN-----QLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            ..|.|::|     ||::||..:.|.|  .:|..::.....:|..:.||.:|||:||:.|.|..:|
Zfish   177 QTLILNNNPLMHAQLRQLPVMVSLQT--LHLRNTQRTQNNMPTSLEGLSNLTDVDLSCNDLTRVP 239

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            :.:..|..|..|.|..|::..|:..:.....::.|.|:.|.|:.||::|.:::||..|.|:.|.:
Zfish   240 ECLYSLVNLKRLNLSSNQISELSLCIDQWTKLETLNLSRNQLTSLPSAICKLSKLKKLYVNSNKI 304

  Fly   326 EY--LPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVW 387
            ::  ||..:|:.:||......:|.|:.:|..|..|..|..|.::.|:|:.||.::..| :|:.:.
Zfish   305 DFDGLPSGVGKLSNLVEFMAANNNLELVPEGLCRCGKLKKLVLNKNRLVTLPEAIHFLTELEVLD 369

  Fly   388 LSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQ----EYQPITPA-------------------- 428
            :.||   |.|...|.....|.|.....:.|..|    ...|.|.|
Zfish   370 VREN---PNLVMPPKPVDRTAEWYNIDFSLQNQLRLAGASPATVAAAGGGNSPRDHMARKMRLRR 431

  Fly   429 -RDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHAN 492
             :|...|.:       ::.|:|...:..|||.............|||.|.....:|:.:.:....
Zfish   432 CKDSAHDDQ-------AKQVLKGMSDVAQEKNKSIEENGDLKYSDLKTKRWDKNLEKPQLDYSEF 489

  Fly   493 LVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQ-----PVVVG----------- 541
            .:   |:.|                          .|.||:..|     |:.|.
Zfish   490 FL---EDVG--------------------------QIPGVSVWQIENFIPIQVDEAFHGKFYEAD 525

  Fly   542 --VVTPTTTTVAPTGVQGGS--------EGASSTANNVKAATAAVVAELAATVGGSD-----EVQ 591
              ::..|...      :.|:        .|..:|.:  |.|.||:.|.......|::     |..
Zfish   526 CYIILKTFLD------ENGALNWQIFYWIGQDATLD--KKAGAAIHAVNLRNYLGAECRTIREEM 582

  Fly   592 DDDEQEDEFESDRRVGFQVEGEDDDFY-----KRPPKLHRRDTPHHLKNKRVQHLTDKQAS---- 647
            .|:.:|.....|..:.:...|....||     :.|.:|:|   .:..||.|::.:..|.:|
Zfish   583 GDESEEFTVVFDHEISYIEGGTASGFYTVEDTQYPTRLYR---VYGKKNIRLESVPLKASSLDPQ 644

  Fly   648 ---------------------------EILANALASQERNDTTPQHSLSGKVTSPIEEEEQ---L 682
                                       .:.|..:...||..       ..::|:.::.:|.   .
Zfish   645 FVFLLDTGLEIYVWRGGNATLGGTTKARLFAEKINKNERKS-------KAEITTLMQNQEPPEFW 702

  Fly   683 EVEQEQQQQQQQH------PFDSSLSPISAG-----------KTAEASTDPDNLDGVTELRLEQY 730
            ||...|.::.::|      |....|..:..|           |.:....|...||.|.||||.|
Zfish   703 EVLGGQPEEIKKHVPDDFTPIRPKLYKVGLGLGYLELPQINYKLSVEHKDKLKLDVVPELRLVQ- 766

  Fly   731 EIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFI---------------SRVTEAGPADLAGLKVG 780
                       ||.            |..|::|               .|:..|     |.||:|
Zfish   767 -----------GLL------------DTKGVYILDCWSDVFIWIGRKSPRLVRA-----AALKLG 803

  Fly   781 DKV 783
            .:|
Zfish   804 QEV 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	74/276 (27%)
		leucine-rich repeat	18..38	CDD:275380	2/19 (11%)
		LRR_8	37..95	CDD:290566	14/57 (25%)
		leucine-rich repeat	39..61	CDD:275380	6/21 (29%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR_8	84..138	CDD:290566	18/55 (33%)
		leucine-rich repeat	85..107	CDD:275380	7/23 (30%)
		leucine-rich repeat	108..130	CDD:275380	6/21 (29%)
		LRR_8	129..187	CDD:290566	16/57 (28%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	2/21 (10%)
		leucine-rich repeat	177..199	CDD:275380	10/21 (48%)
		LRR_8	198..256	CDD:290566	20/62 (32%)
		leucine-rich repeat	200..222	CDD:275380	9/26 (35%)
		leucine-rich repeat	223..245	CDD:275380	4/21 (19%)
		LRR_8	267..325	CDD:290566	17/57 (30%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	7/23 (30%)
		LRR_4	337..375	CDD:289563	11/37 (30%)
		leucine-rich repeat	361..382	CDD:275380	7/21 (33%)
		PDZ	728..816	CDD:214570	13/71 (18%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
flii	NP_001244075.1	LRR_RI	<10..163	CDD:238064	47/180 (26%)
		leucine-rich repeat	10..34	CDD:275380	6/29 (21%)
		LRR_8	33..91	CDD:290566	14/57 (25%)
		leucine-rich repeat	35..57	CDD:275380	6/21 (29%)
		leucine-rich repeat	58..80	CDD:275380	5/21 (24%)
		LRR_8	79..139	CDD:290566	18/59 (31%)
		leucine-rich repeat	83..105	CDD:275380	6/21 (29%)
		LRR_RI	91..374	CDD:238064	91/309 (29%)
		leucine-rich repeat	106..128	CDD:275380	6/21 (29%)
		LRR_8	127..186	CDD:290566	24/80 (30%)
		leucine-rich repeat	129..152	CDD:275380	8/44 (18%)
		leucine-rich repeat	153..175	CDD:275380	10/21 (48%)
		leucine-rich repeat	176..199	CDD:275380	8/22 (36%)
		leucine-rich repeat	200..224	CDD:275380	6/25 (24%)
		LRR_8	223..281	CDD:290566	17/57 (30%)
		leucine-rich repeat	225..247	CDD:275380	9/21 (43%)
		leucine-rich repeat	248..270	CDD:275380	5/21 (24%)
		leucine-rich repeat	271..293	CDD:275380	7/21 (33%)
		leucine-rich repeat	294..318	CDD:275380	7/23 (30%)
		leucine-rich repeat	319..339	CDD:275380	5/19 (26%)
		leucine-rich repeat	342..364	CDD:275378	7/21 (33%)
		gelsolin_S1_like	491..603	CDD:200446	22/148 (15%)
		gelsolin_like	617..705	CDD:200436	14/97 (14%)
		gelsolin_S3_like	722..836	CDD:200448	25/114 (22%)
		gelsolin_like	931..1024	CDD:200436
		gelsolin_S5_like	1043..1142	CDD:200444
		gelsolin_S6_like	1153..1252	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910