DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and ERBIN

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:XP_005248611.1 Gene:ERBIN / 55914 HGNCID:15842 Length:1460 Species:Homo sapiens


Alignment Length:1599 Identity:444/1599 - (27%)
Similarity:674/1599 - (42%) Gaps:332/1599 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGL 67
            :|:   :|....|..:|..||||.|||:||..:.:|||||:||||.|.:|||..|....|.||.|
Human    15 RCL---RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSL 76

  Fly    68 SDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLT 132
            .||::..||..|.|..||.|||||:|.|.:.|::||:.:.|.:.:.|.|||.|||.|||||.|||
Human    77 PDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

  Fly   133 VLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYL 197
            .|.|||..|..|||:||.||:|:.||||||.||.||:|:::||:|:|||||.||..::|..|..|
Human   142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206

  Fly   198 PGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDG 262
            .||.|.|:|.|:|..:|..:|.|.:|||||||:|.:|.:...||...:|.||.|:.|.|:.||:.
Human   207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPET 271

  Fly   263 IAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY 327
            |..|..:|.||:|:|:|..|.|::|...:::||..:.|.:..||:||||:|.|.....|.|.|:.
Human   272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336

  Fly   328 LPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSEN 391
            ||.|||...|:.||.|..|||:.||.|:|:...|.|:::|.|:|..||:|...| ||.|:|||:|
Human   337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401

  Fly   392 QSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPF-----EEREPSRTVVKFS 451
            ||:||:..|.:||:||.:.||:.|:.||   ||.|......||:|.|     ||:...|..|.|.
Human   402 QSKPLIPLQKETDSETQKMVLTNYMFPQ---QPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFE 463

  Fly   452 -EEATQEKETP-----FVRQNTPHPKDLK--AKAQKLKVERSRNEEHANLVTLPEENGTKLAETP 508
             :|...|:|.|     ..|..||:|.:||  .|..:..|.|.::||      ..|::|..|    
Human   464 CDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEE------TNEDSGRDL---- 518

  Fly   509 TETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQ-------GGS-EGASST 565
                        :||..||.|    :|.   |||.|..:||...:.|.       |.| :..|..
Human   519 ------------KPHEDQQDI----NKD---VGVKTSESTTTVKSKVDEREKYMIGNSVQKISEP 564

  Fly   566 ANNVKAATAAVVAELAATVGGSDEVQDDD--EQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRD 628
            ...:...:..|.|.:.|:......|..||  |:.:|..||..:...        ..|||      
Human   565 EAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMA--------EMRPP------ 615

  Fly   629 TPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVT-----------SPIEEEEQL 682
                        |.:...::....||::.:::||....|||.:||           ||....:.:
Human   616 ------------LIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSV 668

  Fly   683 EVEQEQQQ-------------------QQQQHPFDSSL--SPISAGKTAEASTDPDNLDGVTELR 726
            .:..:..|                   :|:...|:|.|  ..|....|.|.....|..|    ..
Human   669 SLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKD----FN 729

  Fly   727 LEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVV 791
            |.:|::::|.....:..|:    .||....|..                  |:....:.:|.::.
Human   730 LPEYDLNVEERLVLIEKSV----DSTATADDTH------------------KLDHINMNLNKLIT 772

  Fly   792 VDADHYQAVQVLK----ACGAVLVLVVQREVTRLI----GHPVFSEDGSVSQISVETRPLVADAP 848
            .|....:.::..|    ..|...:.:..:|.|..:    .:|.......|:..|.||     ...
Human   773 NDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEET-----SQS 832

  Fly   849 PAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSG---------NVFAT--PTAAQT 902
            |..:..|:......:.|....:.|..|:..|:..|..:||.:.         ::.:.  |....|
Human   833 PNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPST 897

  Fly   903 VQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFS---IAGGKGSPPFKDDC-----D 959
            .....||.....::..:.|.|.|.|      ..|:..|...|   |:|.|..  ||.|.     :
Human   898 TVKITSAVDGKNIVRSKSATLLYDQ------PLQVFTGSSSSSDLISGTKAI--FKFDSNHNPEE 954

  Fly   960 GIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGP-- 1022
            ...|...|.|           ......|.|.......:.::.|        |:..|....:.|  
Human   955 PNIIRGPTSG-----------PQSAPQIYGPPQYNIQYSSSAA--------VKDTLWHSKQNPQI 1000

  Fly  1023 ----LEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTP--TPKPTVPA- 1080
                ..|...|||.:..|. |.:.:.||  .|||          .:|.:...|.  ..:...|| 
Human  1001 DHASFPPQLLPRSESTENQ-SYAKHSAN--MNFS----------NHNNVRANTAYHLHQRLGPAR 1052

  Fly  1081 -----SISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSG 1140
                 :||.|:..:|:...:.....::.:..:|.....|...|...:|.||........::|.:.
Human  1053 HGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTP 1117

  Fly  1141 EAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARP--NEVGVSAVTV---NVNKPQP------ 1194
            ...|.|.|||::..:.       :.|.:..:...|||  ||:....::|   |.::..|      
Human  1118 PMMPGSQRPLSARTYS-------IDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNA 1175

  Fly  1195 ---------DLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEV---------- 1240
                     |.|.....|.:            :.|.|:..|...:|.:.::|...          
Human  1176 RVGSEHSLLDPPGKSKVPRD------------WREQVLRHIEAKKLEKSMLSRSFNSNFTTVSSF 1228

  Fly  1241 ------VLPKNQGSLGFSII-----GG--------TDHSCVPFGTREPGIFISHIVPGGIASKCG 1286
                  .|..:||||..|:.     ||        |..|..|.   :.|||||.......|:...
Human  1229 HCGSSRDLHGSQGSLALSVADRRGSGGHIFRKHPQTSSSGDPC---QDGIFISGQQNYSSATLSH 1290

  Fly  1287 KLRMGDRILKV------------NEADVSKATHQDAVLELLKPG-----DEIKLTIQHDP----- 1329
            |....|.::|:            .:|:.|:..|.........|.     |.:.|.:.|.|     
Human  1291 KDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQP 1355

  Fly  1330 -LPP------GFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRL 1387
             ..|      ..||:.:...:...||..|.||:.| ||||..|.|:|:||:::...|.|.:  .|
Human  1356 HCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGG-RGNPFRPDDDGIFVTRVQPEGPASK--LL 1417

  Fly  1388 KVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCK 1426
            :.|.::::.||:|.:...|..||::|:...|.::|::.:
Human  1418 QPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVR 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 137/269 (51%)
leucine-rich repeat 18..38 CDD:275380 10/19 (53%)
LRR_8 37..95 CDD:290566 32/57 (56%)
leucine-rich repeat 39..61 CDD:275380 13/21 (62%)
leucine-rich repeat 62..84 CDD:275380 10/21 (48%)
LRR_8 84..138 CDD:290566 30/53 (57%)
leucine-rich repeat 85..107 CDD:275380 11/21 (52%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
LRR_8 129..187 CDD:290566 36/57 (63%)
leucine-rich repeat 131..153 CDD:275380 13/21 (62%)
leucine-rich repeat 154..176 CDD:275380 13/21 (62%)
leucine-rich repeat 177..199 CDD:275380 11/21 (52%)
LRR_8 198..256 CDD:290566 26/57 (46%)
leucine-rich repeat 200..222 CDD:275380 9/21 (43%)
leucine-rich repeat 223..245 CDD:275380 11/21 (52%)
LRR_8 267..325 CDD:290566 22/57 (39%)
leucine-rich repeat 269..289 CDD:275380 9/19 (47%)
leucine-rich repeat 292..314 CDD:275380 9/21 (43%)
leucine-rich repeat 315..337 CDD:275380 9/21 (43%)
LRR_4 337..375 CDD:289563 16/37 (43%)
leucine-rich repeat 361..382 CDD:275380 9/21 (43%)
PDZ 728..816 CDD:214570 11/91 (12%)
PDZ_signaling 931..1016 CDD:238492 16/92 (17%)
PDZ 1239..1329 CDD:214570 27/135 (20%)
PDZ_signaling 1336..1425 CDD:238492 29/88 (33%)
ERBINXP_005248611.1 leucine-rich repeat 24..47 CDD:275380 11/22 (50%)
LRR_8 46..104 CDD:290566 32/57 (56%)
LRR_RI <48..209 CDD:238064 88/160 (55%)
leucine-rich repeat 48..70 CDD:275380 13/21 (62%)
leucine-rich repeat 71..93 CDD:275380 10/21 (48%)
leucine-rich repeat 94..116 CDD:275380 11/21 (52%)
leucine-rich repeat 117..139 CDD:275380 13/21 (62%)
LRR_RI <130..314 CDD:238064 90/183 (49%)
LRR_8 139..194 CDD:290566 35/54 (65%)
leucine-rich repeat 140..162 CDD:275380 13/21 (62%)
leucine-rich repeat 163..185 CDD:275380 13/21 (62%)
leucine-rich repeat 186..208 CDD:275380 11/21 (52%)
leucine-rich repeat 209..231 CDD:275380 9/21 (43%)
LRR_8 230..288 CDD:290566 26/57 (46%)
leucine-rich repeat 255..277 CDD:275380 10/21 (48%)
leucine-rich repeat 278..300 CDD:275380 9/21 (43%)
leucine-rich repeat 301..323 CDD:275380 9/21 (43%)
LRR_8 322..380 CDD:290566 25/57 (44%)
leucine-rich repeat 347..369 CDD:275380 10/21 (48%)
LRR_4 368..411 CDD:289563 20/42 (48%)
leucine-rich repeat 370..390 CDD:275380 8/19 (42%)
PDZ_signaling 1369..1455 CDD:238492 29/88 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BA7S
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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