DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lingo4b

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001082850.1	Gene:	lingo4b / 559074	ZFINID:	ZDB-GENE-091214-3	Length:	604	Species:	Danio rerio

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	208/525 - (39%)	Gaps:	81/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CNRQVEFVD--KRHCSLPQVPEEILRYSRTLEELFLDANHIRDLP-KNFFRLHRLRKLGLSDNEI 72
            |:|....|:  .||  |..|||.:...::.|:   |..|.::.|. :.|..|.:|..|.||:|.|
Zfish    35 CSRDPLEVNCSSRH--LTAVPEGLPTNAKRLD---LSGNQLKTLARRQFSSLSKLEDLDLSENII 94

  Fly    73 GRLPPDIQNFE---------------------------NLVELDVSRNDIPDIPD-DIKHLQSLQ 109
            ..:  :::.|:                           ||..||:|.|:|....| ..:.:.:||
Zfish    95 SMI--EVETFQGLKNLRYLRIKNNRLKILPVGVFSGLSNLRRLDISENEILVFLDYTFRDMINLQ 157

  Fly   110 VADFSSNPIPKLPS-GFSQLKNLTVLGLNDMSLTTLPADFGSLTQLES---LELRENLLKHLPET 170
            ..|...|.:..:.. .|..|:.|..|.::..:||::|.:  :|:||:|   |.||:..:..||..
Zfish   158 QLDAGENDLVFISQRAFVGLQALKELNVDRSNLTSIPTE--ALSQLQSLTKLRLRKLTISVLPNN 220

  Fly   171 ----ISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLP-PELGLLTKLTYLDVSE 230
                :.||..|:.|.....|:.:....:|.  .|..|.|.:..|..:| ..|..|..|.|||:|.
Zfish   221 AFRRLHQLRTLQILHWSSLEMLNSNSLVGL--NLTTLVLTNCNLSAIPYSPLRHLAYLQYLDLSY 283

  Fly   231 NRLEELPNEISG-LVSLTDLDL-AQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDT-LGNCENM 292
            |.:..:...:.| |:.|.:|.| ..|||...|.....|||..:|.:..|||..|.:: ..:..|:
Zfish   284 NPITSIQGNLLGDLLRLQELHLVGGNLLRIEPGAFRGLSRFRLLNVSSNRLSTLEESAFHSVGNL 348

  Fly   293 QELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGN 357
            |.|.|..|.|:.....:..|.:...|:.|.......||      |....:.||....:| |.:..
Zfish   349 QTLRLDRNPLACDCRLLWVMRRRRRLDFDGRQPTCSPL------NHQRKAFRDFSEAEL-PVVFT 406

  Fly   358 CTVLHVLDVSGNQLLYLPYSLVNLQLKA--------VWLSENQSQPLLTFQPDTDAETGEQVLSC 414
            |....:|:.....:..:....|:...||        .|||..||  .|:........|...:...
Zfish   407 CRQAQILNRQLQDISVIEGMRVHFDCKADGYPSPSITWLSAQQS--ALSSAGRVRVLTNGSLQIS 469

  Fly   415 YLLPQQEYQPITPA-----RDLESDSEPFEEREPSRTVVKFSEEATQEKETP-----FVRQNTPH 469
            |...|.....:..|     .|..|.|...|....:|||..||:|...|...|     ..|.::|:
Zfish   470 YAQVQDSGTYLCSAANAAGNDSISVSLHVEGLPQNRTVSYFSDEGWIETSAPPSTNSSARVSSPY 534

  Fly   470 PKDLK 474
            |.|.|
Zfish   535 PFDAK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	84/311 (27%)
		leucine-rich repeat	18..38	CDD:275380	7/21 (33%)
		LRR_8	37..95	CDD:290566	19/85 (22%)
		leucine-rich repeat	39..61	CDD:275380	6/22 (27%)
		leucine-rich repeat	62..84	CDD:275380	7/48 (15%)
		LRR_8	84..138	CDD:290566	16/55 (29%)
		leucine-rich repeat	85..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..130	CDD:275380	6/22 (27%)
		LRR_8	129..187	CDD:290566	18/64 (28%)
		leucine-rich repeat	131..153	CDD:275380	6/21 (29%)
		leucine-rich repeat	154..176	CDD:275380	9/28 (32%)
		leucine-rich repeat	177..199	CDD:275380	4/21 (19%)
		LRR_8	198..256	CDD:290566	19/60 (32%)
		leucine-rich repeat	200..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..245	CDD:275380	8/22 (36%)
		LRR_8	267..325	CDD:290566	16/58 (28%)
		leucine-rich repeat	269..289	CDD:275380	5/20 (25%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	4/21 (19%)
		LRR_4	337..375	CDD:289563	7/37 (19%)
		leucine-rich repeat	361..382	CDD:275380	2/20 (10%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lingo4b	NP_001082850.1	LRRNT	28..61	CDD:214470	9/27 (33%)
		leucine-rich repeat	41..62	CDD:275380	7/22 (32%)
		LRR	<56..304	CDD:227223	63/256 (25%)
		leucine-rich repeat	63..83	CDD:275380	6/22 (27%)
		leucine-rich repeat	84..107	CDD:275380	7/24 (29%)
		leucine-rich repeat	108..131	CDD:275380	0/22 (0%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..203	CDD:275380	8/24 (33%)
		leucine-rich repeat	204..251	CDD:275380	11/48 (23%)
		leucine-rich repeat	228..250	CDD:275380	4/21 (19%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..297	CDD:275380	7/20 (35%)
		LRR_8	299..358	CDD:316378	20/58 (34%)
		leucine-rich repeat	300..321	CDD:275380	7/20 (35%)
		leucine-rich repeat	324..344	CDD:275380	5/19 (26%)
		I-set	415..498	CDD:254352	16/84 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910