DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and PIDD1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_005253062.1	Gene:	PIDD1 / 55367	HGNCID:	16491	Length:	934	Species:	Homo sapiens

Alignment Length:	569	Identity:	155/569 - (27%)
Similarity:	208/569 - (36%)	Gaps:	177/569 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 ADFSSNPIPKL----------PSGFSQLKNLTV-----------LGLN--------DMSLTTLPA 146
            :|..|..:|.|          |.|..||.:|.|           |.|:        :.:|..||.
Human    23 SDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQ 87

  Fly   147 DFGSLTQLESLEL-----RENL-------LKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPG 199
               ||:.|.||.|     |:.|       |.:||..:|.|..|..|||..|.:|.||..:..:.|
Human    88 ---SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRG 149

  Fly   200 LHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIA 264
            |..|.|.||.|..||..||.|..||:|.|:.|||:.||..:..|.:|..|||:||||:.||..|.
Human   150 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 214

  Fly   265 KLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLP 329
            .|..|..|.|..||||.|..:|....:::.|:|..|.|:.:||.:.:                ||
Human   215 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLAR----------------LP 263

  Fly   330 LEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQ 394
            |       |..|.||||:|:.|||||        ||.        |:  |.|          |..
Human   264 L-------LTRLDLRDNQLRDLPPEL--------LDA--------PF--VRL----------QGN 293

  Fly   395 PLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTV-------VKFSE 452
            ||....||..:.           |.....|..|...|.||.:.|.......:|       ::|..
Human   294 PLGEASPDAPSS-----------PVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPA 347

  Fly   453 EATQEKETPFVRQNTPHP--------------------------KDL---------KAKAQKLKV 482
            .||....|...|...|.|                          :|:         :|:..:..|
Human   348 GATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVV 412

  Fly   483 ERSRNEEH-ANLVTLPEENGTKLAETPTETRTIANNHQQQPH-----PVQQPIVGVNSKQPVVVG 541
            .|:||:.. .:|.|..||      |.|.....    |.|.||     .|.:|:..        ..
Human   413 VRTRNDNSWGDLETYLEE------EAPQRLWA----HCQVPHFSWFLVVSRPVSN--------AC 459

  Fly   542 VVTPTTTTVAPTGVQGGS----EGASSTANNVKAATAAVVA-ELAATVG 585
            :|.|..|.:..:|..|..    .||:.....|......:.. ||.|.:|
Human   460 LVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	77/212 (36%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	12/55 (22%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	8/28 (29%)
		LRR_8	129..187	CDD:290566	25/88 (28%)
		leucine-rich repeat	131..153	CDD:275380	9/40 (23%)
		leucine-rich repeat	154..176	CDD:275380	11/33 (33%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	28/57 (49%)
		leucine-rich repeat	200..222	CDD:275380	11/21 (52%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	15/57 (26%)
		leucine-rich repeat	269..289	CDD:275380	9/19 (47%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	3/21 (14%)
		LRR_4	337..375	CDD:289563	14/37 (38%)
		leucine-rich repeat	361..382	CDD:275380	4/20 (20%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
PIDD1	XP_005253062.1	leucine-rich repeat	39..63	CDD:275380	6/23 (26%)
		leucine-rich repeat	64..91	CDD:275380	7/29 (24%)
		LRR_RI	<117..>279	CDD:238064	71/184 (39%)
		LRR_8	126..183	CDD:290566	25/56 (45%)
		leucine-rich repeat	127..152	CDD:275380	10/24 (42%)
		leucine-rich repeat	153..172	CDD:275380	10/18 (56%)
		leucine-rich repeat	173..195	CDD:275380	10/21 (48%)
		LRR_8	194..252	CDD:290566	24/57 (42%)
		leucine-rich repeat	196..218	CDD:275380	12/21 (57%)
		leucine-rich repeat	219..241	CDD:275380	9/21 (43%)
		LRR_8	240..295	CDD:290566	27/105 (26%)
		leucine-rich repeat	242..264	CDD:275380	7/37 (19%)
		leucine-rich repeat	265..286	CDD:275380	14/36 (39%)
		ZU5	325..398	CDD:295340	10/72 (14%)
		Peptidase_S68	421..453	CDD:287439	11/41 (27%)
		ZU5	465..537	CDD:295340	10/44 (23%)
		Death_PIDD	812..897	CDD:260049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910