DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc47

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001103842.1	Gene:	lrrc47 / 553404	ZFINID:	ZDB-GENE-060503-289	Length:	565	Species:	Danio rerio

Alignment Length:	591	Identity:	138/591 - (23%)
Similarity:	211/591 - (35%)	Gaps:	146/591 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LGYL-----PGLHELW-----LDH--------NQLQRLPPELGLLTKLTYLDVSENRLEELPNEI 240
            |.||     |.|||:.     |.|        |:|..:|..:|.|..:..||:|.|:|:.||.||
Zfish    52 LNYLEVSQCPSLHEIHENIRNLSHLQSLILCRNKLTSVPKSIGHLKAVKVLDLSVNQLQALPEEI 116

  Fly   241 SGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTL--GNCENMQELILTENFLS 303
            ..|..|..|:::.|.|.|||||::|..:|..:.:.:|.|.||.:.|  ...|.:..:|.:||.:.
Zfish   117 CALTELNTLNVSCNSLTALPDGLSKCVKLASINVSKNELSRLPEDLWCSGLELLSSIIASENAIE 181

  Fly   304 ELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKL--KKLPPELGNCTVLHVLDV 366
            ||.:.|..:..|..|::..|.|:.||.|:..|..|...:.:.|||  |:|...:..|....|||
Zfish   182 ELSSEIQNLPSLKVLDLSNNKLQELPAELADCPKLKETNFKGNKLKDKRLEKMVNGCPTKSVLD- 245

  Fly   367 SGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDL 431
                           .|:|....:.:.:       ..|.|..|:|.|.....:::     .|...
Zfish   246 ---------------YLRAGGRGKGKGK-------QQDGEVSEKVDSGRNASKKK-----SAAKQ 283

  Fly   432 ESDSEPFEEREPSRTVVKF-----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491
            :|..|..:..|.::.||:.     |..|...|.:..|:...|:......|...|   |..|....
Zfish   284 KSKKEEEDVDELNQMVVRILHISESPTAVTVKVSAAVKDVRPYIVCCIVKGMNL---RQGNSLKR 345

  Fly   492 NLVTLPEENGTKLAETPTETRTIAN--NHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTG 554
            .||.     .|||.:.....||.|.  .|.          :|: .|.|::.....|.|..:.|.|
Zfish   346 FLVA-----QTKLHDEICAKRTTATIATHD----------LGL-LKYPLLYDARPPDTLKIIPLG 394

  Fly   555 VQGGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQ-----VEGED 614
                       ...|||..  ::.:|.         |:..||..:.:.....|..     ::|:|
Zfish   395 -----------RKEVKAVD--LLRQLQ---------QEAHEQRKQKKRQNVSGLHKYLQLLDGKD 437

  Fly   615 ---------DDFYKRPPKLHRRDTPHHLKNK----RVQHLTDKQASEILANAL------------ 654
                     |.....||..:...|......|    .|...|..|..:.:.:||
Zfish   438 LYPCLVDAEDHVISFPPITNSDKTKIKKTTKELFLEVTSSTSLQICKDVMDALIIKMAELNKLSF 502

  Fly   655 ------ASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEAS 713
                  .|.|.......|        |.||....|:...|.:...   .|.:|..:...|| :..
Zfish   503 DSKEVVGSDEETTAVSDH--------PAEEPTSFELTVLQVKVVD---VDGNLKVVYPSKT-DLM 555

  Fly   714 TDPDNL 719
            :.|.||
Zfish   556 SSPSNL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	38/106 (36%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380	3/9 (33%)
		LRR_8	198..256	CDD:290566	24/70 (34%)
		leucine-rich repeat	200..222	CDD:275380	10/34 (29%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	16/59 (27%)
		leucine-rich repeat	269..289	CDD:275380	6/21 (29%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	8/21 (38%)
		LRR_4	337..375	CDD:289563	10/39 (26%)
		leucine-rich repeat	361..382	CDD:275380	3/20 (15%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc47	NP_001103842.1	LRR_RI	<74..212	CDD:238064	46/137 (34%)
		LRR_8	74..132	CDD:290566	19/57 (33%)
		leucine-rich repeat	76..98	CDD:275380	5/21 (24%)
		leucine-rich repeat	99..121	CDD:275380	10/21 (48%)
		leucine-rich repeat	122..144	CDD:275380	10/21 (48%)
		leucine-rich repeat	145..169	CDD:275380	6/23 (26%)
		LRR_8	170..226	CDD:290566	16/55 (29%)
		leucine-rich repeat	170..192	CDD:275380	6/21 (29%)
		leucine-rich repeat	193..215	CDD:275380	8/21 (38%)
		B3_4	324..497	CDD:214876	41/213 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910