DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Grip

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	1146	Identity:	222/1146 - (19%)
Similarity:	371/1146 - (32%)	Gaps:	402/1146 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 LAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDF--YKRPPKLHRRDTPHHLKNKRVQHLT 642
            :...|.|.......|:|:.:.:       |.|..::.|  :..||                   |
  Fly    10 IGGCVPGKSAALKQDQQQQQQQ-------QQESHNNSFNGHHHPP-------------------T 48

  Fly   643 DKQASEIL----ANALASQERNDTTPQHSLS-GKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLS 702
            |...:.:|    |.:.|..|.:...|:...: ..:|.| .....|.:...::......|...||:
  Fly    49 DTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLP-RNALHLAITFAERNDLSYPPVVGSLN 112

  Fly   703 PISAGKTAEASTDPDNL---DGVTELRLE----------------------QY------------ 730
            |:  |..|:.....|.|   ||::.:.|.                      :|
  Fly   113 PV--GHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSL 175

  Fly   731 -------EIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAG-LKVGDKVIKVN 787
                   :|.:||.:..|||::.||.        |..:.::.|...||....| :|.||::::|:
  Fly   176 CVTSKLAQITVERESGCLGLTLRGGA--------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVD 232

  Fly   788 GIVVVDADHYQAVQVLKACGAV------------------------LVLVVQREVTRLIGHPV-- 826
            .:.::.....:|.|::|..|.|                        |::.::|.:...:|..:
  Fly   233 NVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCN 297

  Fly   827 -----------FSEDGSVSQISVETRPLVADAPPAA--------------------SISHERYIP 860
                       .|...|..:|.......:|...||:                    .|.|..:.|
  Fly   298 YTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSP 362

  Fly   861 APIEIV---PQQQHLQQQQQQPIQQVA---------PTHSYS-------------GNVFATPTAA 900
            ..:..:   ...:...|.|..|...:|         |.:|:|             ...||..::.
  Fly   363 DEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSL 427

  Fly   901 QTVQPA--VSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCD---G 960
            ....||  ...:..|.:..|        .:|.:   ..:|.|||...|   .|.|...||.   |
  Fly   428 PLENPACGTPGSTGGSMGTG--------GIHGS---SSLGMGLGLCRA---ESFPVLLDCSHGAG 478

  Fly   961 IFISRITEG---------------GLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTE---- 1006
            |.:|....|               .:|.|.|.|..|||::|||.....:|   ||:..|.|
  Fly   479 IILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDA---AAMRQLLEGGSS 540

  Fly  1007 --------PQRFVRLVLQREYRGPLEPPTSPRSPAVLNS------LSPSG----------YLANR 1047
                    |..::.|.::.:....:.|.:...|..:|.:      ||.||          .....
  Fly   541 RNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGS 605

  Fly  1048 PANFSRS------VVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTL-PSSKTNGFATAAAATI 1105
            ||:.|.|      ::.|:|          .|.....|.|.:.....:. ||..::.|.|.....|
  Fly   606 PAHRSGSLRSGDILLAVDQ----------HPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRI 660

  Fly  1106 DSSTGQPVPAPRRTNSVPMG-DGDIGAGSTTSGD---------------------SGEAQPSSLR 1148
            ......|:.:|..:|....| :..:|.|.:||.|                     |...||...|
  Fly   661 VLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFR 725

  Fly  1149 PLTSDDF-----------------QAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDL 1196
            ..:.||.                 ||   |:..|.|...:.:||.||   ..::|..:.:.:.:.
  Fly   726 VPSMDDASLQSVQLRSGSGSNGGNQA---ANSWSTGVNSRSYVAPPN---TQSLTTELPEEEDEQ 784

  Fly  1197 -PMFP-------------AAPTEL-----GRVTETITKSTFTETVMTRITDNQLAEPLISEEVVL 1242
             .|:|             |.|..:     |....:.:||:.:.......|            |.|
  Fly   785 EQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFT------------VRL 837

  Fly  1243 PKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVS--KA 1305
            ....|.||.::.|..|.:        ..|.||.:|.||||.|.|::.:||::|.::|..|.  ..
  Fly   838 EPKGGLLGITLAGSEDIT--------KSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPL 894

  Fly  1306 THQDAVLELLKPGD--EIKLTIQHD--------------------PLPPGFQ-EVLLSKAEGERL 1347
            :|..::|:.|  ||  ::|:...||                    |..|... |.......|...
  Fly   895 SHATSLLQNL--GDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNAN 957

  Fly  1348 GMHIKGGLNGQRGNPADPS------------------------DEGVFVSKINSVGAARRDGRLK 1388
            |   .|.:||..|: ..|.                        :.|||:::|.|.|.|...|.||
  Fly   958 G---GGAVNGNSGS-GKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLK 1018

  Fly  1389 VGMRLLEVNGHSLLGASHQD-----AVNVLRNAGNEIQLVV 1424
            ...|:::||     ....||     .|.::..||::|::::
  Fly  1019 PFDRIMQVN-----EMKTQDFDCCLTVPLIAAAGDKIEMIM 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	24/153 (16%)
		PDZ_signaling	931..1016	CDD:238492	30/114 (26%)
		PDZ	1239..1329	CDD:214570	30/113 (27%)
		PDZ_signaling	1336..1425	CDD:238492	27/118 (23%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	14/67 (21%)
		PDZ_signaling	183..254	CDD:238492	21/78 (27%)
		PDZ_signaling	278..375	CDD:238492	12/96 (13%)
		PDZ	496..>521	CDD:294084	8/24 (33%)
		PDZ_signaling	571..658	CDD:238492	19/96 (20%)
		PDZ_signaling	832..913	CDD:238492	29/102 (28%)
		PDZ_signaling	973..1055	CDD:238492	19/87 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010