DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Sntg1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001178910.1	Gene:	Sntg1 / 500394	RGDID:	1560290	Length:	519	Species:	Rattus norvegicus

Alignment Length:	176	Identity:	44/176 - (25%)
Similarity:	69/176 - (39%)	Gaps:	35/176 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 KLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEV-LLSKAEGERLGMH 1350
            :|.:...:|.:.|.||                    |.:..:|...|.:.| :.|::.|.|.|:.
  Rat    28 RLHLARDLLMLQEQDV--------------------LCVSGEPFYSGVRLVKIFSQSVGCRFGLS 72

  Fly  1351 IKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRN 1415
            |.|||.         ....||..|::....:...|.|.:|..:|::||.::....|::.|.||||
  Rat    73 ILGGLT---------HSVPVFAGKLSKSQDSELSGLLFIGDAILQINGINVRKCRHEEVVQVLRN 128

  Fly  1416 AGNEIQLVV-----CKGYDKSNLIHSIGQAGGMSTGFNSSASCSGG 1456
            ||.|:.|.|     ...:.|..|......|....:...||..|..|
  Rat   129 AGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSG 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	6/41 (15%)
		PDZ_signaling	1336..1425	CDD:238492	29/94 (31%)
Sntg1	NP_001178910.1	PDZ_signaling	55..137	CDD:238492	28/90 (31%)
		PH	192..260	CDD:214574
		PH	197..260	CDD:278594
		PH	285..390	CDD:214574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910