DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and OMD

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_005005.1	Gene:	OMD / 4958	HGNCID:	8134	Length:	421	Species:	Homo sapiens

Alignment Length:	437	Identity:	104/437 - (23%)
Similarity:	168/437 - (38%)	Gaps:	102/437 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DFSSNPIPKLPSGFSQLKNLT--------VLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLP 168
            |:...|.....:||...:|:.        .||.  :|....|.:|.|....::.:|:  .:.::|
Human    30 DYDQEPDDDYQTGFPFRQNVDYGVPFHQYTLGC--VSECFCPTNFPSSMYCDNRKLK--TIPNIP 90

  Fly   169 ETISQL------------------TKLKRLDLGDNEIEDLPPYLGY---LPGLHELWLDHNQLQR 212
            ..|.||                  |.||.::|..|:|:......|.   ||.|.:|.|:||.|:.
Human    91 MHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEE 155

  Fly   213 LPPELGLLTKLTYLDVSENRLEEL-PNEISGLVSLTDLDLAQNLL--EALPDGI-AKLSRLTILK 273
            .|  ..|...|..|.:..|.:.:| .|.:.|||:||.|||..|.|  ..|.|.| ||:.:|..|.
Human   156 FP--FPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLN 218

  Fly   274 LDQNRLQRLNDTLGNCENMQELILTENFLSELPAS-IGQMTKLNNLNVDRNALEYLPLEIGQCAN 337
            |..|||:.:...|.:  ::..|.|..|.:|.:|.. ..::.||:.|.:..|.|:.:|..|....|
Human   219 LCSNRLESMPPGLPS--SLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPN 281

  Fly   338 LGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPD 402
            :..||:..||||                    |..|:|.:|.:|.|:                 :
Human   282 IVELSVGHNKLK--------------------QAFYIPRNLEHLYLQ-----------------N 309

  Fly   403 TDAETGEQVLSCYLLPQQEYQPITPAR-DLESDSEPFEER----EPSRTVVKFSEEATQEKETPF 462
            .:.|.....:.|..:....|..:|..| |.....||....    .|....:.:.|:.:...:|
Human   310 NEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQT-- 372

  Fly   463 VRQNTPHPKDLKAKAQ---KLKVERSRNEEH---ANLVTLPEENGTK 503
                      ::.|.|   :...:...:|:|   .|....||:.|.:
Human   373 ----------IQLKTQVFRRFPDDDDESEDHDDPDNAHESPEQEGAE 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	59/203 (29%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	7/33 (21%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	4/17 (24%)
		LRR_8	129..187	CDD:290566	17/83 (20%)
		leucine-rich repeat	131..153	CDD:275380	6/29 (21%)
		leucine-rich repeat	154..176	CDD:275380	5/39 (13%)
		leucine-rich repeat	177..199	CDD:275380	7/24 (29%)
		LRR_8	198..256	CDD:290566	23/58 (40%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	7/22 (32%)
		LRR_8	267..325	CDD:290566	16/58 (28%)
		leucine-rich repeat	269..289	CDD:275380	7/19 (37%)
		leucine-rich repeat	292..314	CDD:275380	5/22 (23%)
		leucine-rich repeat	315..337	CDD:275380	6/21 (29%)
		LRR_4	337..375	CDD:289563	9/37 (24%)
		leucine-rich repeat	361..382	CDD:275380	4/20 (20%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
OMD	NP_005005.1	NEL	<68..>305	CDD:330839	75/262 (29%)
		LRR 1	92..113		3/20 (15%)
		leucine-rich repeat	94..116	CDD:275380	2/21 (10%)
		LRR 2	116..129		5/12 (42%)
		leucine-rich repeat	117..142	CDD:275380	7/24 (29%)
		LRR 3	142..164		8/23 (35%)
		leucine-rich repeat	143..163	CDD:275380	8/21 (38%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		LRR 4	165..184		4/18 (22%)
		LRR 5	187..210		10/22 (45%)
		leucine-rich repeat	188..213	CDD:275380	12/24 (50%)
		LRR 6	213..233		7/19 (37%)
		leucine-rich repeat	214..234	CDD:275380	7/21 (33%)
		LRR 7	234..255		5/20 (25%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRR 8	258..280		7/21 (33%)
		leucine-rich repeat	259..281	CDD:275380	6/21 (29%)
		LRR 9	281..294		7/32 (22%)
		leucine-rich repeat	282..301	CDD:275380	9/38 (24%)
		LRR 10	301..321		4/36 (11%)
		LRR 11	331..353		5/21 (24%)
		leucine-rich repeat	332..356	CDD:275380	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..421		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910