DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc8c

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_004913784.1	Gene:	lrrc8c / 493197	XenbaseID:	XB-GENE-5797483	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	98/326 - (30%)
Similarity:	153/326 - (46%)	Gaps:	22/326 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDI-------- 79
            ||:......:......|:.|.:..:.:|:||...:.|..|.:|.|    ||.|.||:
Frog   470 CSVKIHSAALAFLKENLKILRVKFDDVRELPPWMYGLRNLEELYL----IGSLSPDVSKNITLDS 530

  Fly    80 -QNFENLVELDVSRN--DIPDIPDDIK-HLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMS 140
             :..::|..|.:..|  .||....|:. |||.|.:.:..:..:  :.:...::.|||.|.|....
Frog   531 FRELKSLKHLFIKSNLSKIPQGAVDVSGHLQKLCIHNDGTKLV--MLNNLKKMVNLTELDLIHCD 593

  Fly   141 LTTLPADFGSLTQLESLELRENLLKHLPETIS--QLTKLKRLDLGDNEIEDLPPYLGYLPGLHEL 203
            |..:.....||..||.|.|:||.||.:.|.:|  .|.||..|.|..|.|..:|..:..|..|..|
Frog   594 LDHIHHSIFSLLALEELNLKENNLKSIQEIVSFQYLRKLTILKLWYNSITHIPVEIKKLTSLERL 658

  Fly   204 WLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSR 268
            :..||:::.||.:|.|..||.|||:|.|.:..:|.||..:.||....::.|.:|::||.:....:
Frog   659 YFSHNKIEVLPSQLFLCHKLRYLDLSYNDIRFIPPEIGVMQSLQYFSISCNKVESVPDELYFCKK 723

  Fly   269 LTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIG--QMTKLNNLNVDRNALEYLPLE 331
            |..||:.:|.|..|:..:||...:..|.:..|....||..:|  :..|.|.|.|:....|.||.:
Frog   724 LITLKIGKNNLCSLSPKIGNLVLLSYLDIKGNHFETLPPELGDCRALKKNGLIVEDTLFETLPFD 788

  Fly   332 I 332
            |
Frog   789 I 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	82/273 (30%)
		leucine-rich repeat	18..38	CDD:275380	2/14 (14%)
		LRR_8	37..95	CDD:290566	17/68 (25%)
		leucine-rich repeat	39..61	CDD:275380	6/21 (29%)
		leucine-rich repeat	62..84	CDD:275380	8/30 (27%)
		LRR_8	84..138	CDD:290566	15/56 (27%)
		leucine-rich repeat	85..107	CDD:275380	8/24 (33%)
		leucine-rich repeat	108..130	CDD:275380	1/21 (5%)
		LRR_8	129..187	CDD:290566	24/59 (41%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	11/23 (48%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	21/57 (37%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	9/21 (43%)
		LRR_8	267..325	CDD:290566	17/59 (29%)
		leucine-rich repeat	269..289	CDD:275380	7/19 (37%)
		leucine-rich repeat	292..314	CDD:275380	5/23 (22%)
		leucine-rich repeat	315..337	CDD:275380	7/18 (39%)
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc8c	XP_004913784.1	Pannexin_like	1..331	CDD:372171
		leucine-rich repeat	439..461	CDD:275380
		leucine-rich repeat	462..485	CDD:275380	2/14 (14%)
		leucine-rich repeat	486..508	CDD:275380	6/21 (29%)
		leucine-rich repeat	509..536	CDD:275380	8/30 (27%)
		LRR	519..785	CDD:227223	81/267 (30%)
		leucine-rich repeat	537..559	CDD:275380	6/21 (29%)
		leucine-rich repeat	560..583	CDD:275380	3/24 (13%)
		leucine-rich repeat	584..606	CDD:275380	7/21 (33%)
		leucine-rich repeat	607..631	CDD:275380	11/23 (48%)
		leucine-rich repeat	632..654	CDD:275380	7/21 (33%)
		leucine-rich repeat	655..677	CDD:275380	8/21 (38%)
		leucine-rich repeat	701..723	CDD:275380	5/21 (24%)
		leucine-rich repeat	724..746	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910