DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP007461

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_001237077.2	Gene:	AgaP_AGAP007461 / 4576239	VectorBaseID:	AGAP007461	Length:	384	Species:	Anopheles gambiae

Alignment Length:	354	Identity:	98/354 - (27%)
Similarity:	148/354 - (41%)	Gaps:	76/354 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLH----RLRKLGLSDNEI 72
            |..|..:...||||..:|       ||          ||::| |..||.    |:|.|.|:
Mosquito    69 NVNVSLLHIEHCSLTGMP-------RT----------IRNVP-NLLRLAIKSCRIRHLDLN---- 111

  Fly    73 GRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLN 137
                 |..:..:|..:|::.|.|..|      .:.|..:|.      .||.....|.|.::..||
Mosquito   112 -----DFADLHSLYSVDLTNNRIVTI------TELLPASDL------VLPINRLYLANNSLTQLN 159

  Fly   138 DMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHE 202
            ..:|       |:||.|..|.|..|.::.:...|: |.||:.|.|.:|.|:.|.....:||.|..
Mosquito   160 VRAL-------GALTDLHCLVLEGNRIEEVNSPIA-LPKLEELSLRNNRIKQLNCTGWHLPALKY 216

  Fly   203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEA--------- 258
            |:...|:|...|.|...:.::..||:|.|.|.....:...|..|..|:||.|.|.:
Mosquito   217 LFCSGNRLSIAPIEWQSMWRIEVLDLSFNLLHSFRMDDIYLTQLYALNLAGNQLTSVTTPQMHFR 281

  Fly   259 LPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRN 323
            :|     ||||.   |.||||..|:.:..:..|:.||.:..|.|:||.....:...|..:.:.||
Mosquito   282 VP-----LSRLW---LAQNRLPVLDISRWDMPNLWELDVAHNRLTELADVFVRFPNLAPMMILRN 338

  Fly   324 ---ALEYL----PLEIGQCANLGVLSLRD 345
               :.|:|    |.::.: .|.|.||..:
Mosquito   339 NQWSCEWLARVHPTDLRR-KNYGCLSTNE 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	79/282 (28%)
		leucine-rich repeat	18..38	CDD:275380	5/19 (26%)
		LRR_8	37..95	CDD:290566	16/61 (26%)
		leucine-rich repeat	39..61	CDD:275380	6/25 (24%)
		leucine-rich repeat	62..84	CDD:275380	4/21 (19%)
		LRR_8	84..138	CDD:290566	12/53 (23%)
		leucine-rich repeat	85..107	CDD:275380	5/21 (24%)
		leucine-rich repeat	108..130	CDD:275380	5/21 (24%)
		LRR_8	129..187	CDD:290566	18/57 (32%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	6/21 (29%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	18/57 (32%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	6/21 (29%)
		LRR_8	267..325	CDD:290566	19/60 (32%)
		leucine-rich repeat	269..289	CDD:275380	7/19 (37%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	6/28 (21%)
		LRR_4	337..375	CDD:289563	4/9 (44%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP007461	XP_001237077.2	LRR_8	71..129	CDD:290566	22/84 (26%)
		leucine-rich repeat	72..94	CDD:275380	11/39 (28%)
		LRR_RI	78..319	CDD:238064	84/295 (28%)
		leucine-rich repeat	95..118	CDD:275380	7/31 (23%)
		leucine-rich repeat	119..146	CDD:275380	9/38 (24%)
		LRR_8	147..201	CDD:290566	19/61 (31%)
		leucine-rich repeat	147..168	CDD:275380	7/27 (26%)
		LRR_4	169..205	CDD:289563	12/36 (33%)
		leucine-rich repeat	169..190	CDD:275380	6/21 (29%)
		LRR_8	189..247	CDD:290566	19/57 (33%)
		leucine-rich repeat	191..213	CDD:275380	7/21 (33%)
		leucine-rich repeat	214..236	CDD:275380	6/21 (29%)
		leucine-rich repeat	237..259	CDD:275380	6/21 (29%)
		leucine-rich repeat	307..329	CDD:275380	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910