DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and MPP3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001317162.1	Gene:	MPP3 / 4356	HGNCID:	7221	Length:	610	Species:	Homo sapiens

Alignment Length:	603	Identity:	117/603 - (19%)
Similarity:	202/603 - (33%)	Gaps:	187/603 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 RPPKLHR------RDTPHHLKNKRVQHLTDKQASEILA--NALASQERNDTTP-QHSLSGKVTSP 675
            ||...|:      ||.           .::|..|.::.  ..|...||...|| .||........
Human    47 RPDSNHKEEMGFLRDV-----------FSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDV 100

  Fly   676 IEEEEQLEVEQEQQQQQQ------------------QHPFDSSLSPISAGKTAEASTDPDNLDGV 722
            :||.:...|..::::..|                  |..||..|.|:           |||:|
Human   101 MEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPL-----------PDNID-- 152

  Fly   723 TELRLEQYE------IHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGL-KVG 780
                 |.::      :.:.:....||.:|...:.|       ..:.::|:...|.||.:|| .||
Human   153 -----EDFDEESVKIVRLVKNKEPLGATIRRDEHS-------GAVVVARIMRGGAADRSGLVHVG 205

  Fly   781 DKVIKVNGIVVVDADHYQAVQVL-KACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLV 844
            |::.:||||.|:.....:..|:| ::.|::.:.::          |...|:..:.:..|..|.|.
Human   206 DELREVNGIAVLHKRPDEISQILAQSQGSITLKII----------PATQEEDRLKESKVFMRALF 260

  Fly   845 ADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVA---PTHSYSGNVFATPTAAQTVQPA 906
            ...|     ..:|.||.      |:..|..|::|.::.|:   ||...:..|..|...|
Human   261 HYNP-----REDRAIPC------QEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRA------ 308

  Fly   907 VSAAPNGLLLNG--REAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKD-------DCDGIF 962
                  ||:.:.  :|..|||.:...||...|           ....||:..       ||:|..
Human   309 ------GLIPSKGFQERRLSYRRAAGTLPSPQ-----------SLRKPPYDQPCDKETCDCEGYL 356

  Fly   963 ISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPT 1027
            ......|  ..|..::...:|:.......|:.......:....|..|:..           :|..
Human   357 KGHYVAG--LRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQH-----------QPGE 408

  Fly  1028 SPRSPAVLNSLS------PSGYLANRPANFSRSVVEVEQPYK--------YNTLATTTPTPKPTV 1078
            .||...::.||.      ....:|..|.:|..:|....:|.|        |:.::      |...
Human   409 RPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVS------KQAF 467

  Fly  1079 PASISNNNNTLPSS--KTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGE 1141
            .|.: ::|..|...  |.|.:.|:..|         :.|....|.|.:.|
Human   468 EADL-HHNKFLEHGEYKENLYGTSLEA---------IQAVMAKNKVCLVD--------------- 507

  Fly  1142 AQPSSLRPLTSDDFQAMI 1159
            .:|.:|:.|.:.:|:..|
Human   508 VEPEALKQLRTSEFKPYI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	22/95 (23%)
		PDZ_signaling	931..1016	CDD:238492	14/91 (15%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
MPP3	NP_001317162.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910