DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and MPP2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_011523129.2	Gene:	MPP2 / 4355	HGNCID:	7220	Length:	630	Species:	Homo sapiens

Alignment Length:	160	Identity:	37/160 - (23%)
Similarity:	62/160 - (38%)	Gaps:	43/160 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   833 VSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTH-SYSGNVFAT 896
            |.:|..:...|...:..||.::|          :.|:.|        .|.:..|| |.:...:.|
Human   149 VQEILRDLAQLAEQSSTAAELAH----------ILQEPH--------FQSLLETHDSVASKTYET 195

  Fly   897 PTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLG--FSIAGGKGSPPFKDDCD 959
            |..:..:.|..|..|         .|...:::  ..||...|:.||  |.:.||:
Human   196 PPPSPGLDPTFSNQP---------VPPDAVRM--VGIRKTAGEHLGVTFRVEGGE---------- 239

  Fly   960 GIFISRITEGGLAYRDGKIMVGDRVMAING 989
             :.|:||..||:..:.|.:.|||.:..:||
Human   240 -LVIARILHGGMVAQQGLLHVGDIIKEVNG 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	19/61 (31%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
MPP2	XP_011523129.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910