DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and cDIP

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	116/500 - (23%)
Similarity:	197/500 - (39%)	Gaps:	139/500 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IFKGC-----------NRQVEFVDKRHCSLPQVPEEILRYSRTLEE---LFLDANHIRDLPKNFF 57
            ||:.|           ..:|..:|.|.|.:..:..|  .:|...::   |.|..|||..||...|
  Fly    99 IFENCTFTNFPLRLFYTLEVSELDMRGCGIRFIYWE--NFSIGADKLVILLLSDNHIEVLPTKTF 161

  Fly    58 R-LHRLRKLGLSDNEIGRLPPDIQNFENLVE---LDVSRNDIPDIPDDIKHLQSLQVADFSSNPI 118
            | ...|..:.|:.|::|:|....  |:||::   ||::.|.:..:..|:
  Fly   162 RGAGNLEFIFLNRNKLGKLQAGA--FDNLLKLQYLDLTENRLEALAADV---------------- 208

  Fly   119 PKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLG 183
                  |:.||:|..:||....|||:.:|               |..|.|:.:|       :.:.
  Fly   209 ------FAGLKSLRHVGLAGNQLTTIESD---------------LFAHNPDLLS-------VAMQ 245

  Fly   184 DNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTD 248
            :|.:.::..|.....|      .|:|:|             |:|:|.|     |..:..|:::..
  Fly   246 NNRLREVGEYAFRSRG------RHHQMQ-------------YVDLSNN-----PELVVLLLNINA 286

  Fly   249 LDL-AQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQM 312
            .:| |:|   ...|.:.....:|.:.|..||::.|  .....|.::.|:|..|.|.:| ||:.::
  Fly   287 TNLTARN---CSLDRVNLYGSVTNVDLSDNRVREL--YFPASEALEHLVLRNNSLVQL-ASLSRV 345

  Fly   313 TKLNNLNV-DRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPE-LGNCTVLHVLDVSGNQLLYL- 374
            .:|.:|:| |...|..|| :..:..:|.:|.||:....:||.| |.....|..||:|||.|..:
  Fly   346 PRLRHLDVADNPNLGQLP-DGWRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEID 409

  Fly   375 PYSLVNL-QLKAVWLSENQ-------------------SQPLLTFQPDTDAETGEQVLSCYLLPQ 419
            |.:...| ||...::..|.                   :..:..:.||...|....:...|.||:
  Fly   410 PSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIACMYRLPE 474

  Fly   420 Q---------------EYQPITPARDLESDSEPFEEREPSRTVVK 449
            :               |..|||.:.|   .||..:.|:..:.||:
  Fly   475 KEGVDSSSSSEISASVESSPITSSSD---PSEVDKLRDELKAVVQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	61/277 (22%)
		leucine-rich repeat	18..38	CDD:275380	5/19 (26%)
		LRR_8	37..95	CDD:290566	20/64 (31%)
		leucine-rich repeat	39..61	CDD:275380	9/25 (36%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	12/56 (21%)
		leucine-rich repeat	85..107	CDD:275380	5/24 (21%)
		leucine-rich repeat	108..130	CDD:275380	2/21 (10%)
		LRR_8	129..187	CDD:290566	13/57 (23%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	4/21 (19%)
		leucine-rich repeat	177..199	CDD:275380	2/21 (10%)
		LRR_8	198..256	CDD:290566	13/58 (22%)
		leucine-rich repeat	200..222	CDD:275380	3/21 (14%)
		leucine-rich repeat	223..245	CDD:275380	6/21 (29%)
		LRR_8	267..325	CDD:290566	17/58 (29%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	7/22 (32%)
		LRR_4	337..375	CDD:289563	15/39 (38%)
		leucine-rich repeat	361..382	CDD:275380	9/22 (41%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/25 (24%)
		LRR_RI	143..407	CDD:238064	86/340 (25%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	18/82 (22%)
		leucine-rich repeat	167..190	CDD:275380	8/24 (33%)
		leucine-rich repeat	191..214	CDD:275380	6/44 (14%)
		leucine-rich repeat	215..238	CDD:275380	9/37 (24%)
		leucine-rich repeat	239..265	CDD:275380	5/38 (13%)
		leucine-rich repeat	266..325	CDD:275380	16/81 (20%)
		LRR_8	304..357	CDD:290566	17/55 (31%)
		leucine-rich repeat	326..347	CDD:275380	7/21 (33%)
		leucine-rich repeat	348..394	CDD:275380	15/46 (33%)
		LRR_8	369..428	CDD:290566	19/58 (33%)
		LRR_4	393..433	CDD:289563	12/39 (31%)
		leucine-rich repeat	395..418	CDD:275380	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910