Protein Alignment scrib and f-cup

DIOPT Version :10

• Sequence 1: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Sequence 2: NP_001262544.1
• Gene: f-cup / 41677
• FlyBaseID: FBgn0028487
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 972
• Identity: 207/972 - (21%)
• Similarity: 329/972 - (33%)
• Gaps: 382/972 - (39%)

  Fly    65 LGLSDNEIGRLPP---DIQ---------NFENLV--ELDVSRNDIPDIPDDIKHLQSLQVADFSS 115
            |.||:..:.|:|.   ||.         |.|.|.  |.|...|.:|           |...|.||
  Fly   112 LNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVP-----------LNNLDLSS 165

  Fly   116 NPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRL 180
            |.:..:......|::||||.|:|.:|..||.:.|.|.:|..|.:..|.|..||..:..|.:|:.|
  Fly   166 NTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHL 230

  Fly   181 DLGDNEIEDLPPYLGYLPGLHEL-WLD--HNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISG 242
            ::..||..:|.|.:.   .||.| :||  ||.:|.||..:|.|.:||.|.:..|.::|||.::..
  Fly   231 NISYNEFVELNPDIS---DLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVN 292

  Fly   243 LVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPA 307
            :.||..:||..|.|.:||:.:..|.:|..|.|..|.:..|.:..|| |.:.||..:.||:..:|.
  Fly   293 MRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGN-EALNELHASNNFIKIIPK 356

  Fly   308 SIGQMTKLNNLNVDRNALEYLPLEIGQCAN---LGVLSLRDNKLKKLPPELGNCTVLHVLDVSGN 369
            ::                         |:|   |.:|.|||||:.:||.||.....|:.||||.|
  Fly   357 AM-------------------------CSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNN 396

  Fly   370 QLLYLPYS------LVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPA 428
            .:..||.:      |::||:        :..|:.|.:.|        :|.|
  Fly   397 TISVLPVTLSSLAHLISLQV--------EGNPIKTIRRD--------ILQC-------------- 431

  Fly   429 RDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANL 493
                                                                             
  Fly   432 ----------------------------------------------------------------- 431

  Fly   494 VTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGG 558
                   ||        ||.:...|.:                            .||....:||
  Fly   432 -------GT--------TRILKTLHDR----------------------------AVAKAKEEGG 453

  Fly   559 SEGASSTANNVKAATAAVVAELAATVGGSDEVQDDD------------EQEDEFESDRRVGFQVE 611
            ....:||:..:.      |..|.   ||  ::.|.|            :|::.|:.......|.:
  Fly   454 GVDDASTSAGIS------VTRLR---GG--QMDDGDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQ 507

  Fly   612 GEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPI 676
            .....|....|          |:|.:..   |:|....:      .|..:...||. :|.:.|..
  Fly   508 QMQQQFCVYEP----------LRNCQEY---DRQTQGRI------YEPENYQQQHQ-NGSLRSLF 552

  Fly   677 EEEEQLEVE-------QEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHI 734
            .:::|..:|       ..|||||||..::.               ||.:...|....:  |::..
  Fly   553 VQQQQQRMEYPYPGYFMYQQQQQQQFSYEQ---------------DPSSRSAVHPRWV--YKLRH 600

  Fly   735 ERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKV---NGIVVVDADH 796
            .||.|                     :.:..:|          .|.|:|.::   .|:.|||...
  Fly   601 TRTLA---------------------VNLEELT----------SVPDQVFQIARDEGVHVVDFAR 634

  Fly   797 YQ------AVQVLKACGAVLVLVVQREVTRLIGH-PVF-SEDGSVSQISVETRPLVADAPP---- 849
            .|      .:|.:|.....|||     ...:||: |.| |:...:|.:::... |:.|.|.
  Fly   635 NQLSTLPNGLQHMKDLVTELVL-----SNNVIGYVPQFISQFTRISFLNLSNN-LLNDLPTEFGV 693

  Fly   850 -----AASISHERYIPAP--------IEI-VPQQQHLQ----------------QQQQQPIQQVA 884
                 ..:|::.|:...|        :|| :..:.|::                ..:...|:.|.
  Fly   694 LNTLRELNIANNRFPCIPNCVYELQGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIETVP 758

  Fly   885 P--------TH-SYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQI 937
            |        || ...||.|..|.             :.:|:.|.:|.:||       :||:|
  Fly   759 PILGNLTNITHLELVGNPFRQPR-------------HQILMKGTDAIMSY-------LRDRI 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:404697	13/43 (30%)
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380	8/30 (27%)
		LRR	67..408	CDD:443914	111/366 (30%)
		leucine-rich repeat	85..107	CDD:275380	5/23 (22%)
		leucine-rich repeat	108..130	CDD:275380	6/21 (29%)
		leucine-rich repeat	131..153	CDD:275380	11/21 (52%)
		leucine-rich repeat	154..176	CDD:275380	7/21 (33%)
		leucine-rich repeat	177..199	CDD:275380	6/21 (29%)
		leucine-rich repeat	200..222	CDD:275380	12/24 (50%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	5/21 (24%)
		leucine-rich repeat	315..337	CDD:275380	1/21 (5%)
		leucine-rich repeat	361..382	CDD:275380	9/26 (35%)
		PDZ1_Scribble-like	730..816	CDD:467188	18/94 (19%)
		PDZ2_Scribble-like	927..1019	CDD:467187	3/11 (27%)
		PDZ3_Scribble-like	1238..1327	CDD:467186
		PDZ4_Scribble-like	1331..1428	CDD:467185
f-cup	NP_001262544.1	LRR	98..428	CDD:443914	112/371 (30%)
		leucine-rich repeat	111..140	CDD:275380	7/27 (26%)
		leucine-rich repeat	158..180	CDD:275380	6/21 (29%)
		leucine-rich repeat	181..203	CDD:275380	11/21 (52%)
		leucine-rich repeat	204..226	CDD:275380	7/21 (33%)
		leucine-rich repeat	227..249	CDD:275380	7/24 (29%)
		leucine-rich repeat	250..272	CDD:275380	10/21 (48%)
		leucine-rich repeat	273..295	CDD:275380	7/21 (33%)
		leucine-rich repeat	296..318	CDD:275380	8/21 (38%)
		leucine-rich repeat	319..340	CDD:275380	7/21 (33%)
		leucine-rich repeat	341..364	CDD:275380	7/47 (15%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		leucine-rich repeat	411..430	CDD:275380	6/34 (18%)
		leucine-rich repeat	627..650	CDD:275380	6/22 (27%)
		LRR	<629..>778	CDD:443914	31/154 (20%)
		leucine-rich repeat	651..669	CDD:275380	7/22 (32%)
		leucine-rich repeat	697..719	CDD:275380	3/21 (14%)
		leucine-rich repeat	720..743	CDD:275380	3/22 (14%)
		leucine-rich repeat	744..766	CDD:275380	3/21 (14%)