DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc59

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_998097.1	Gene:	lrrc59 / 405868	ZFINID:	ZDB-GENE-040426-2547	Length:	314	Species:	Danio rerio

Alignment Length:	342	Identity:	81/342 - (23%)
Similarity:	132/342 - (38%)	Gaps:	99/342 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 VSENRLEELPNEISGLVSLTDLDLA-QNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCEN 291
            :::.::|.:.::|.|    .:|||: .||.|.....:|...:.|.|.|             :|.|
Zfish     1 MNKGKIENIKDKIDG----NELDLSLSNLTEVPVKELAAFPKATFLDL-------------SCNN 48

  Fly   292 MQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELG 356
            :  :.||..|.|        :|.|..:::::|.|..||.||||..||..|.|.:||||.||
Zfish    49 L--ITLTPEFCS--------LTHLIKIDLNKNQLVCLPEEIGQLVNLQHLDLYNNKLKMLP---- 99

  Fly   357 NCTVLHVLDVSGNQLLYLPYSLVNLQLKAV-W--LSENQSQPLLTFQPDTDAETGEQVLSCYLLP 418
                             :.:|    |||:: |  |.:|..:|.|. :...|....:|...|....
Zfish   100 -----------------IGFS----QLKSLKWLDLKDNPLEPTLA-KAAGDCLDEKQCRQCASRV 142

  Fly   419 QQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVE 483
            .|..:.:....:.|.:....:|||..:     .:||.|       |:.....|:.:.|.:..:.|
Zfish   143 LQHMKVLQEEAEKELERRLLKEREQEK-----KKEAKQ-------REKEAREKEAQKKKKAEEKE 195

  Fly   484 RSRNEEHANL--VTLPEENGTKLAETPTETRTIANNHQQQPHPVQQP------------------ 528
            |.|.|..|.:  |...|:...|..|   :.:..|.|..::..|...|
Zfish   196 RKRKEYQAQVAAVAAQEQQKKKKEE---KKKKAAQNQGKKAAPESVPKAKRSICSLFFSLLLKLV 257

  Fly   529 ---IVGVNSKQPVVVGV 542
               ::||:|    ||.|
Zfish   258 LLLVIGVSS----VVAV 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	13/55 (24%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566	7/28 (25%)
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380	3/16 (19%)
		LRR_8	267..325	CDD:290566	12/57 (21%)
		leucine-rich repeat	269..289	CDD:275380	3/19 (16%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	10/37 (27%)
		leucine-rich repeat	361..382	CDD:275380	1/20 (5%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc59	NP_998097.1	leucine-rich repeat	108..119	CDD:275378	3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..197		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..237		6/27 (22%)
		LRR 1	14..35		7/24 (29%)
		leucine-rich repeat	17..38	CDD:275378	7/20 (35%)
		LRR 2	38..60		9/44 (20%)
		leucine-rich repeat	39..61	CDD:275378	9/44 (20%)
		LRR_8	60..118	CDD:290566	27/82 (33%)
		LRR 3	61..82		8/20 (40%)
		leucine-rich repeat	62..84	CDD:275378	9/21 (43%)
		LRR_4	84..120	CDD:289563	17/60 (28%)
		LRR 4	84..106		12/46 (26%)
		leucine-rich repeat	85..107	CDD:275378	12/46 (26%)
		LRR 5	107..126		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910