DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and dlg4b

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_999893.1	Gene:	dlg4b / 405796	ZFINID:	ZDB-GENE-040628-3	Length:	801	Species:	Danio rerio

Alignment Length:	953	Identity:	202/953 - (21%)
Similarity:	300/953 - (31%)	Gaps:	392/953 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 FESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLT---DKQASEILANALASQERND 661
            |:||.   ||...:..:||:                     ||   ::.|...|...|..:..::
Zfish    37 FQSDL---FQALLDIQEFYE---------------------LTVFENQTAGRALTPGLKYRYHDE 77

  Fly   662 TTP--QHS----LSGKVTSPIE--EEEQLEVEQEQQQQQQQH--PFDSSLSPISAGKTAEASTDP 716
            .||  |||    .:||....:.  :.....::.......|.|  |....|.|.........||..
Zfish    78 ETPPLQHSPAHLSTGKSAEMLHLGDSGHAPIDGIHAYTPQMHVSPAKPVLLPSGHAPYYATSTLM 142

  Fly   717 DNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAG-LKVG 780
            :.:||    .:|..||.:||..:|||.|||||. ..|..|||..|||:::...|.|...| |:|.
Zfish   143 NGMDG----DVEYEEITLERGNSGLGFSIAGGT-DNPHIGDDPSIFITKIIPGGAAAQDGRLRVN 202

  Fly   781 DKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVA 845
            |.::.||.:.|.:..|..||:.||..|.::.|.|.|.
Zfish   203 DSILFVNDVDVREVTHSFAVEALKEAGPIVRLYVLRH---------------------------- 239

  Fly   846 DAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAA 910
             .|.|..|:..:.|..|
Zfish   240 -KPSAEKITELKLIKGP------------------------------------------------ 255

  Fly   911 PNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRD 975
                                        :|||||||||.|:.....| :.|::::|.|||.|::|
Zfish   256 ----------------------------KGLGFSIAGGVGNQHVPGD-NSIYVTKIIEGGAAHKD 291

  Fly   976 GKIMVGDRVMAINGNDMTEAHHDAAVACLTEP-----QRFVRLVLQREYRGPLEPPTSPRSPAVL 1035
            |::.:||:::|:|...:.|..|:.|||.|...     .|..:.:.|..::....||.      :.
Zfish   292 GRLQIGDKILAVNNMYLEEVMHEDAVAALKNTGDVVFLRVAKTLHQHHHQDAYNPPD------IT 350

  Fly  1036 NSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATA 1100
            :|.||...:::.|...|                                     |||
Zfish   351 SSYSPHMDMSDYPQALS-------------------------------------PSS-------- 370

  Fly  1101 AAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLS 1165
                           |||.:.:|.|                        |..||
Zfish   371 ---------------PRRYSPIPKG------------------------LFLDD----------- 385

  Fly  1166 GGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQ 1230
                                                   ::.|
Zfish   386 ---------------------------------------DISR---------------------- 389

  Fly  1231 LAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRIL 1295
              ||   ..||:.:....|||:|:||.|..         |||||.|:.||.|...|:||.||:||
Zfish   390 --EP---RRVVIHRGSTGLGFNIVGGEDGE---------GIFISFILAGGAADLSGELRKGDQIL 440

  Fly  1296 KVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRG 1360
            .||..|:..|||:.|...|...|..:.:..|:.|     :|  .|:.|.:   :|   .|..|..
Zfish   441 SVNGVDLRHATHEQAAAALKNAGQTVTIITQYRP-----EE--YSRFEAK---IH---DLREQLM 492

  Fly  1361 NPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVC 1425
            |           |.:.|..|:.|.|:....:|.|.....:..|.....||:.  ..|:.:|:..|
Zfish   493 N-----------SSLVSAAASLRSGKRSFFIRALFDYDKTADGGFLSQAVSF--RFGDVLQVFDC 544

  Fly  1426 KGYDKSNLIHSIGQAGGMS-------TGFNSS---ASCSGGSRQGSRASE--------------- 1465
            ..       ....|||.::       ||:..|   ......||..:|..|
Zfish   545 SD-------EEWWQAGKLAPHGELEETGYIPSKRRVERKEWSRLKTRGREPVSGRSDYIVSYETV 602

  Fly  1466 TGSELSQSQSV----SSLDHEEDERLRQDFDVFASQKPDAQQP 1504
            |.||:..::.|    .|.|...|:.|.:..|.|.|..|...:|
Zfish   603 TQSEVHYARPVIILGPSKDRVNDDLLSEFPDKFGSCVPHTTRP 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	37/88 (42%)
		PDZ_signaling	931..1016	CDD:238492	30/89 (34%)
		PDZ	1239..1329	CDD:214570	35/89 (39%)
		PDZ_signaling	1336..1425	CDD:238492	19/88 (22%)
dlg4b	NP_999893.1	L27_1	4..58	CDD:286187	9/44 (20%)
		MAGUK_N_PEST	71..152	CDD:287565	17/84 (20%)
		PDZ	153..237	CDD:278991	35/84 (42%)
		PDZ	245..331	CDD:214570	32/162 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373		11/99 (11%)
		PDZ_assoc	342..392	CDD:287558	21/216 (10%)
		PDZ_signaling	391..471	CDD:238492	35/91 (38%)
		SH3	509..574	CDD:302595	14/73 (19%)
		Guanylate_kin	609..788	CDD:279019	10/37 (27%)
		GuKc	617..788	CDD:214504	9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910