Protein Alignment scrib and tlr8b

DIOPT Version :9

• Sequence 1: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Sequence 2: NP_001373638.1
• Gene: tlr8b / 403136
• ZFINID: ZDB-GENE-040219-12
• Length: 1015
• Species: Danio rerio
• Alignment Length: 537
• Identity: 131/537 - (24%)
• Similarity: 212/537 - (39%)
• Gaps: 124/537 - (23%)

  Fly    36 SRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPD-IQNFENLVELDVSRNDIPDIP 99
            |.|...|.....:::.:|||.  :.....|.|::|:|..:..| ..|..|:..:|:.||.|....
Zfish    31 SNTSVTLDCSERYLKKIPKNL--IWNTTNLNLANNKIHNISKDAFWNLNNVTWIDLRRNQIEKCH 93

  Fly   100 DD-------IKHLQSLQVADFSSNPIPK-LPSGFSQLKNLTVLGLNDMSLTTL-PADFGSLTQLE 155
            :.       :.:|::|.:.:...:.:|| ||:|      |..|.||...:.:: .:||..:|:|.
Zfish    94 EKDNGVFSRLTNLKTLLLDNNKISVLPKNLPAG------LQWLSLNSNHIKSIEQSDFKGMTKLT 152

  Fly   156 SLELRENLLKHLP-------ETISQLTKLKRLDLGDNEIEDLPPYLGYLP-GLHELWLDHNQLQR 212
            .|:|.:|...::.       ||...| :|..|.|..|.:.::|   ..|| .||.|.|..|::..
Zfish   153 VLKLNKNCYHNISAELTIQNETFQHL-QLTELQLSKNGLHNVP---FALPRTLHNLSLLLNRIDH 213

  Fly   213 L-PPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQ 276
            : ..:|..||:|..||:|.|    .|...:.....|......|.|:..|:..:|||:|..|:|..
Zfish   214 VHESDLNHLTRLKVLDLSGN----CPICFTTPFPCTSCQTNNNALQIHPNAFSKLSQLQDLRLSG 274

  Fly   277 NRLQRLNDT-LGNCENMQELILTEN----------FLSELPASIGQMTKLNNLNVDRNALEYLPL 330
            |.||.:|.. ..|..|::.|.|:.|          |.|.||..  ::..::..|........|.|
Zfish   275 NSLQSINSMWFQNLTNLKYLYLSFNSLISEFESGQFFSVLPQV--EVVDISYNNPSERIYPRLKL 337

  Fly   331 EIG--QCANLGVLSLRDNKLKKLPPE----LGNCTVLHVLDVSGNQLLYLPYSLV----NLQLKA 385
            ..|  :..:|..|.|......||..:    |.:...|.||:::.|.|..:..|:.    ||.|
Zfish   338 SEGFSRLESLQTLHLEGYIFHKLSEDDLRPLFSLRNLSVLNLAVNFLQQVNLSVFRNFHNLSL-- 400

  Fly   386 VWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEP-FEEREPSRTVVK 449
            :.|.:|:    |||.                         :|.|..|..|:. |::
Zfish   401 ISLIDNR----LTFS-------------------------SPIRRWEGQSKSGFKD--------- 427

  Fly   450 FSEEATQEKETPFVRQNTP---HPKDLKAK--AQKLKVERSRNE-EHAN--LVTLPEE------- 499
              :.....:|.|::..|..   :|...||:  |....::.|||. .|.|  |.|..|.
Zfish   428 --DNQGDHREGPYIHTNEEFRHYPPFTKAECLATGPVLDLSRNNIYHVNPPLFTGAENITCLNLS 490

  Fly   500 --------NGTKLAETP 508
                    |||:.|..|
Zfish   491 SNFIVSYFNGTEFAHFP 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	72/265 (27%)
		leucine-rich repeat	18..38	CDD:275380	1/1 (100%)
		LRR_8	37..95	CDD:290566	15/58 (26%)
		leucine-rich repeat	39..61	CDD:275380	4/21 (19%)
		leucine-rich repeat	62..84	CDD:275380	6/22 (27%)
		LRR_8	84..138	CDD:290566	15/61 (25%)
		leucine-rich repeat	85..107	CDD:275380	5/28 (18%)
		leucine-rich repeat	108..130	CDD:275380	6/22 (27%)
		LRR_8	129..187	CDD:290566	18/65 (28%)
		leucine-rich repeat	131..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..176	CDD:275380	7/28 (25%)
		leucine-rich repeat	177..199	CDD:275380	7/22 (32%)
		LRR_8	198..256	CDD:290566	17/59 (29%)
		leucine-rich repeat	200..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..245	CDD:275380	6/21 (29%)
		LRR_8	267..325	CDD:290566	18/68 (26%)
		leucine-rich repeat	269..289	CDD:275380	7/20 (35%)
		leucine-rich repeat	292..314	CDD:275380	7/31 (23%)
		leucine-rich repeat	315..337	CDD:275380	4/23 (17%)
		LRR_4	337..375	CDD:289563	11/41 (27%)
		leucine-rich repeat	361..382	CDD:275380	7/24 (29%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
tlr8b	NP_001373638.1	leucine-rich repeat	36..57	CDD:275380	4/22 (18%)
		leucine-rich repeat	58..78	CDD:275380	6/19 (32%)
		LRR_8	64..116	CDD:404697	10/51 (20%)
		leucine-rich repeat	79..105	CDD:275380	4/25 (16%)
		leucine-rich repeat	106..121	CDD:275380	2/14 (14%)
		LRR_8	126..190	CDD:404697	19/70 (27%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		leucine-rich repeat	151..179	CDD:275380	7/28 (25%)
		PLN00113	180..>735	CDD:215061	93/379 (25%)
		leucine-rich repeat	180..224	CDD:275380	14/46 (30%)
		leucine-rich repeat	225..266	CDD:275380	12/44 (27%)
		leucine-rich repeat	267..290	CDD:275380	8/22 (36%)
		leucine-rich repeat	347..373	CDD:275380	6/25 (24%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	462..483	CDD:275380	7/20 (35%)
		leucine-rich repeat	484..508	CDD:275380	5/24 (21%)
		leucine-rich repeat	509..532	CDD:275380
		leucine-rich repeat	563..615	CDD:275380
		leucine-rich repeat	586..607	CDD:275380
		leucine-rich repeat	616..640	CDD:275380
		leucine-rich repeat	641..664	CDD:275380
		leucine-rich repeat	665..688	CDD:275380
		leucine-rich repeat	689..712	CDD:275380
		leucine-rich repeat	713..732	CDD:275380
		LRRCT	747..795	CDD:214507
		TIR	855..997	CDD:214587

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910