DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_989386.1	Gene:	lrrc1 / 395020	XenbaseID:	XB-GENE-943417	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	274/505 - (54%)
Similarity:	358/505 - (70%)	Gaps:	17/505 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            ||.|||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||:|.:||||
Frog     1 MFHCIPLWR-CNRHVESVDKRHCSLLAVPEEIYRYSRSLEELLLDANQLRELPKQFFQLVKLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||||.||||:|.||..|||||||||:||:||:.|...::|||||||.||:.:||..|..|.:
Frog    65 GLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPDSFPDLAS 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            ||.|.:||:||..||.:.|:|:.|.|||||||||..|||:::||.:|:.||:|:||:.:||..:|
Frog   130 LTCLSINDISLQVLPENIGNLSNLVSLELRENLLTFLPESLAQLHRLEELDIGNNELYNLPETIG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .|..|.:||||.|||..||||:|.|..|..||:|||:||.||.|||||.|||||.::.|.:|.||
Frog   195 SLYKLKDLWLDGNQLADLPPEIGHLKNLLCLDLSENKLERLPEEISGLKSLTDLLVSHNSIEVLP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            |||.||..|:|||:|||||.:|.|.:|.||::.|||||||.|..||.|||::.||.|||:|||.|
Frog   260 DGIGKLKNLSILKVDQNRLMQLTDCIGECESLTELILTENQLLVLPRSIGKLKKLCNLNIDRNKL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            ..||.|||.|..|.|..:|:|:|.::|.|:...|.||||||:||:|.:||.||.:|:|||:|||:
Frog   325 MSLPKEIGGCCGLNVFCVRENRLSRIPSEIAKATELHVLDVAGNRLTHLPLSLTSLKLKALWLSD 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQP-----ITPARDLES-----DSEPFEEREPSR 445
            |||:||||||.|.:.|:||::|:|.|.||...:|     :......||     ..|.:.|:..:|
Frog   390 NQSKPLLTFQTDIEPESGEKILTCVLFPQMPSEPSGQDNLPRCGAFESLVNDMSDETWNEKAMNR 454

  Fly   446 -TVVKFSEEATQE---KETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491
             :.::|.::..:|   :....:|:.||||.:|  |..|..||..|:..:|
Frog   455 ISAIRFLDDTKEEDDDESATLLRRATPHPGEL--KNMKKTVENIRSNLNA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	168/269 (62%)
		leucine-rich repeat	18..38	CDD:275380	16/19 (84%)
		LRR_8	37..95	CDD:290566	43/57 (75%)
		leucine-rich repeat	39..61	CDD:275380	15/21 (71%)
		leucine-rich repeat	62..84	CDD:275380	18/21 (86%)
		LRR_8	84..138	CDD:290566	30/53 (57%)
		leucine-rich repeat	85..107	CDD:275380	14/21 (67%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	31/57 (54%)
		leucine-rich repeat	131..153	CDD:275380	11/21 (52%)
		leucine-rich repeat	154..176	CDD:275380	15/21 (71%)
		leucine-rich repeat	177..199	CDD:275380	10/21 (48%)
		LRR_8	198..256	CDD:290566	35/57 (61%)
		leucine-rich repeat	200..222	CDD:275380	14/21 (67%)
		leucine-rich repeat	223..245	CDD:275380	15/21 (71%)
		LRR_8	267..325	CDD:290566	35/57 (61%)
		leucine-rich repeat	269..289	CDD:275380	12/19 (63%)
		leucine-rich repeat	292..314	CDD:275380	13/21 (62%)
		leucine-rich repeat	315..337	CDD:275380	14/21 (67%)
		LRR_4	337..375	CDD:289563	17/37 (46%)
		leucine-rich repeat	361..382	CDD:275380	13/20 (65%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc1	NP_989386.1	leucine-rich repeat	14..37	CDD:275380	18/22 (82%)
		PRK15370	<27..>255	CDD:185268	140/227 (62%)
		leucine-rich repeat	38..60	CDD:275380	15/21 (71%)
		leucine-rich repeat	61..83	CDD:275380	18/21 (86%)
		leucine-rich repeat	84..106	CDD:275380	14/21 (67%)
		leucine-rich repeat	107..129	CDD:275380	13/21 (62%)
		leucine-rich repeat	130..152	CDD:275380	11/21 (52%)
		leucine-rich repeat	153..175	CDD:275380	15/21 (71%)
		LRR	156..>399	CDD:227223	143/242 (59%)
		leucine-rich repeat	176..198	CDD:275380	10/21 (48%)
		leucine-rich repeat	199..221	CDD:275380	14/21 (67%)
		leucine-rich repeat	222..244	CDD:275380	15/21 (71%)
		leucine-rich repeat	245..267	CDD:275380	13/21 (62%)
		leucine-rich repeat	291..313	CDD:275380	13/21 (62%)
		leucine-rich repeat	314..359	CDD:275380	21/44 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11010
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49385
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010