DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and patj

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:XP_005161760.1 Gene:patj / 368723 ZFINID:ZDB-GENE-030616-129 Length:1914 Species:Danio rerio


Alignment Length:1902 Identity:411/1902 - (21%)
Similarity:676/1902 - (35%) Gaps:607/1902 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PQVPEEILRYSRT--LEELFLDANHIRDLPKNFFRLHR--LRKLG--LSDNEIGRLPPDIQNFEN 84
            |.||..  |.|||  ||.               |.:|.  |:|.|  |..:.||.   :....|:
Zfish   344 PPVPAR--RASRTPNLEG---------------FEIHEVALKKEGQSLGISIIGH---NALTSED 388

  Fly    85 LVELDVSRNDIP----------DIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLT-VLGLND 138
            .|.:.| :|.||          .|.|.|..|..:.:..:::..:.::......:.:|| |..:..
Zfish   389 AVGVYV-KNVIPGSIAEQTGKIQIHDRIISLDGVNLQGYNNQEVLEVMKQSGDVVHLTLVRKIIS 452

  Fly   139 MSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLK-RLDLGDNEIEDLPPYLGYL----- 197
            ...||:......: |.||..:          ::.:.:::| |.|...:.:|.:.|.|..:     
Zfish   453 PKRTTMEKSLDKV-QRESSRV----------SLKRSSEMKARADQRGSVVESIDPALSGIKQQLQ 506

  Fly   198 ------PGLHELWLDHNQLQRLPPELGLLTKLTYLD-VSENRLE------ELPNEISGL-VSLTD 248
                  ..|.|:.|.....|.|.|...::  :..|| |.|:.:|      .||.....| |.|..
Zfish   507 ANMQEPASLTEMELRAKWEQALGPHYDVM--IVQLDPVIEDDIELQKYSKLLPIHTMRLGVELDS 569

  Fly   249 LDLAQNLLEALPDG-IAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASI--- 309
            .|....:....|:| :||...|.    .::.|..:|......::.:|.:.   ||.|:|...   
Zfish   570 FDGHHYISTVAPEGPVAKHGLLR----PEDELLEVNGVQLYGKSRRESVA---FLREVPTPFTLV 627

  Fly   310 --GQMTKLNNLNVDRNALEYLP---------LEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHV 363
              .::.|.:|        ||.|         |:.....||.:|: ||..|:....|         
Zfish   628 CCRRLAKEDN--------EYHPESEDWHSSSLQEQIEHNLSMLA-RDTSLRDSIRE--------- 674

  Fly   364 LDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPA 428
                                      |.|::.....:.:.|.| ||.:           :||:|.
Zfish   675 --------------------------EFQARQASAVEREVDDE-GEPL-----------EPISPE 701

  Fly   429 R---DLESDSEPFEERE----------PSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKL 480
            :   |.|:|.:..||.|          |:..|::. |:|  |:...|...:...|.|:   |:.:
Zfish   702 KEQMDQENDDDDEEEEEEDEGELALWSPNVQVLEL-EKA--ERGLGFSILDYQDPMDV---ARSV 760

  Fly   481 KVERSR-----NEEHANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQP--V 538
            .|.||.     .:.|..:  .|.:....:.:|..||.::|           |.:..:.|..|  |
Zfish   761 IVIRSLVPGGVADNHGGI--FPGDQLVFVNDTHLETCSLA-----------QAVEVLKSAPPGKV 812

  Fly   539 VVGVVTPTTTTVAPTGVQG----GSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDE 599
            .:|:..|.......:|.|.    .|.....||....:.|...:.|  ..|.|| .:.||.::|.|
Zfish   813 YLGIRKPLAAEDRGSGQQSLWPVESVDEQPTAKQAVSHTLPPMPE--DFVNGS-ILSDDLDEEPE 874

  Fly   600 F-------------------ESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQ 645
            .                   :.::.:....|.||.|                     |..:.|:|
Zfish   875 LILDAEPRYASPLTTVDLQPDVEKEMAVDEEEEDVD---------------------VNVMEDQQ 918

  Fly   646 ASEI----LANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQ-QQHPFDSSLSPIS 705
            :|::    |.:.|:.:.|:...|..|....:.:..:.:||::.:.....:: |..|....|...:
Zfish   919 SSKVNDTSLPSYLSEKSRSWEEPATSSRYHLNTEPDLQEQVDDDLSMNLEKIQLQPLKIPLGHFT 983

  Fly   706 AG-KTAEASTDPDNLDGVTELRL------------------------------EQYEIHIERTAA 739
            :. :||::.:|..| :| :||.|                              |:.|...|.|..
Zfish   984 SWVETADSDSDSRN-EG-SELTLTDTDNESAQRTSSRNKKRRNQAGPTRGDLPEREEGEGEETPV 1046

  Fly   740 ------------------GLGLSIAGGKGSTPFK----GDD-DGIFISRVTEAGPADLAG-LKVG 780
                              .||:||.||:  |..|    |:: .||||.:|....||...| ||.|
Zfish  1047 FSHWGPPRRVEVWAEPEESLGISIVGGR--TVIKRLKNGEELKGIFIKQVLADSPAGRTGALKTG 1109

  Fly   781 DKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVA 845
            ||:::|:|:.:.:|.|.:|||.:||..:.:|.:||.  ......||.....|:.|...:.:    
Zfish  1110 DKILQVSGVDLQNASHEEAVQTIKAAPSPVVFIVQS--LSSTPRPVSVTASSIKQHKAKRK---- 1168

  Fly   846 DAPPAASISHERYIPAPIEIVP---------QQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQ 901
                ||..:.:...|.|:.:.|         :::|.|:::.:...:|                  
Zfish  1169 ----AAQKAGQGAAPPPMRLPPPYRPPSQVQEEEHEQEEEDEQDTEV------------------ 1211

  Fly   902 TVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRI 966
             ::...:..|..||:             ..|.:|:  .|||.|:||.:..     .|..||:..|
Zfish  1212 -IRQRYADLPGELLI-------------VELEKDR--NGLGLSLAGNRDR-----SCMSIFVVGI 1255

  Fly   967 TEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRS 1031
            |.||.|.|||:|.|||.::.||...:....|..|.|.:......|:|||             .|:
Zfish  1256 TTGGPASRDGRIKVGDELLEINSQVLYGRSHQNASAIIKSAASKVKLVL-------------VRN 1307

  Fly  1032 PAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASI----SNNNNTLPSS 1092
            ...:|.::.:.: .::||.||.|......|        ..|..||.:|.|:    |...|||  :
Zfish  1308 EDAINQMAVTPF-PSQPALFSSSETHENPP--------AVPAEKPQLPESLPLSRSPPENTL--N 1361

  Fly  1093 KTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQA 1157
            |.....||.|::                       |....|.|.|:|.                 
Zfish  1362 KDQACVTATASS-----------------------DPTHKSLTDGESA----------------- 1386

  Fly  1158 MIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQ----PDLPMFPAAPTELGRVTETITKSTF 1218
                          |...:|.|..:.:.:....|||    |.||....:.|:....:..:|.|..
Zfish  1387 --------------VKKLKPAEKLLESPSEQSAKPQVEQIPSLPKLQRSSTKPSAGSLEVTSSAS 1437

  Fly  1219 TETVMTRITDNQLAE------PLI--SEEVV-LPKNQGSLGFSIIGGTDHSCVPFGTREPGIFIS 1274
            :..|.....|.:...      |::  .|.|: :.|.:..||.||:||.|       |:...|.|.
Zfish  1438 SVPVSGTSPDFEYCSKDPATCPIVPGQETVIEISKGRSGLGLSIVGGKD-------TQLDAIVIH 1495

  Fly  1275 HIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQE--- 1336
            .:...|.|::.|:|..||:||:||..|:....|:||:..|.:...:::||:..|......:|   
Zfish  1496 EVYEEGAAARDGRLWAGDQILEVNGVDLRSVAHEDAIAALRQTPPKVRLTVLRDEAQYRDEENLD 1560

  Fly  1337 ---VLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNG 1398
               |.|.|..|..||:.|.|..||          :|||:|.:...|||..||||..|.::|.|:|
Zfish  1561 VFPVELQKKTGRGLGLSIVGKRNG----------KGVFISDVVKGGAADLDGRLMQGDQILSVDG 1615

  Fly  1399 HSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRA 1463
            ..:..||.:....:|:.|..::.|             .:|:             ....|...||.
Zfish  1616 EDMRQASQETVAAILKCARGKVLL-------------ELGR-------------LKAASWISSRR 1654

  Fly  1464 SETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAA 1528
            :..||::|.:...||                      ...||.|:|            :| ||:.
Zfish  1655 TSQGSQMSHASGSSS----------------------TPTPTPPTV------------AP-PPSQ 1684

  Fly  1529 TSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQL---------APLGQEKST 1584
            |.|......|..::.:.:|   .|..:||.:......|        |         :|||.    
Zfish  1685 TPNNNSRNIAEPISKSTVT---EPGVRTVEITRGPTDA--------LGISIAGGKGSPLGD---- 1734

  Fly  1585 QEKVLEIVRAADAFTTVPPKSPSEHHEQ--DKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGA 1647
                :.|..|......|..|:   |..:  |:|     |.|:..:||     ..|.|..:::.  
Zfish  1735 ----IPIFIAMIQANGVAAKT---HRLKVGDRI-----VSINSQSLD-----GLTHADVVNML-- 1780

  Fly  1648 ESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEV 1712
              .|:.||....|.|.|.     :.|:|.|.::.::|            |.|::       ..||
Zfish  1781 --KNAYGAIILQVVADTN-----ISAIASQVESLSSS------------SAPST-------NPEV 1819

  Fly  1713 RAKPTPTKVPKSVSDKK 1729
            |.....|..|||::.:|
Zfish  1820 RLVEPETPKPKSITLEK 1836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 64/294 (22%)
leucine-rich repeat 18..38 CDD:275380 5/11 (45%)
LRR_8 37..95 CDD:290566 16/63 (25%)
leucine-rich repeat 39..61 CDD:275380 3/21 (14%)
leucine-rich repeat 62..84 CDD:275380 6/23 (26%)
LRR_8 84..138 CDD:290566 12/64 (19%)
leucine-rich repeat 85..107 CDD:275380 9/31 (29%)
leucine-rich repeat 108..130 CDD:275380 0/21 (0%)
LRR_8 129..187 CDD:290566 11/59 (19%)
leucine-rich repeat 131..153 CDD:275380 5/22 (23%)
leucine-rich repeat 154..176 CDD:275380 2/21 (10%)
leucine-rich repeat 177..199 CDD:275380 6/33 (18%)
LRR_8 198..256 CDD:290566 17/65 (26%)
leucine-rich repeat 200..222 CDD:275380 6/21 (29%)
leucine-rich repeat 223..245 CDD:275380 8/29 (28%)
LRR_8 267..325 CDD:290566 10/62 (16%)
leucine-rich repeat 269..289 CDD:275380 3/19 (16%)
leucine-rich repeat 292..314 CDD:275380 5/26 (19%)
leucine-rich repeat 315..337 CDD:275380 5/30 (17%)
LRR_4 337..375 CDD:289563 7/37 (19%)
leucine-rich repeat 361..382 CDD:275380 0/20 (0%)
PDZ 728..816 CDD:214570 37/111 (33%)
PDZ_signaling 931..1016 CDD:238492 31/84 (37%)
PDZ 1239..1329 CDD:214570 29/90 (32%)
PDZ_signaling 1336..1425 CDD:238492 31/94 (33%)
patjXP_005161760.1 L27_2 12..69 CDD:117611
PDZ_signaling 131..>191 CDD:238492
PDZ_signaling 238..317 CDD:238492
PDZ 361..449 CDD:214570 20/91 (22%)
PDZ_signaling 563..627 CDD:238492 16/70 (23%)
PDZ_signaling 731..817 CDD:238492 22/104 (21%)
PDZ_signaling 1053..1144 CDD:238492 32/92 (35%)
PDZ 1222..1307 CDD:214570 34/117 (29%)
MPDZ_u10 1398..1463 CDD:293272 12/64 (19%)
PDZ 1464..1549 CDD:214570 30/91 (33%)
PDZ_signaling 1561..1641 CDD:238492 30/102 (29%)
PDZ_signaling 1707..1792 CDD:238492 23/117 (20%)
PDZ_signaling 1829..1913 CDD:238492 4/8 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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