DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and scrib

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_021333089.1	Gene:	scrib / 368473	ZFINID:	ZDB-GENE-030616-572	Length:	2047	Species:	Danio rerio

Alignment Length:	2521	Identity:	799/2521 - (31%)
Similarity:	1095/2521 - (43%)	Gaps:	756/2521 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            |.||||::: |||.||.||||||||..||:||.||:|:||||.||||.:|:|||.|||||.||||
Zfish     1 MLKCIPLWR-CNRHVESVDKRHCSLTAVPDEIYRYNRSLEELLLDANQLRELPKPFFRLHNLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||||.:||||:.||..|||||:|||||.:||::||..|||::||||.||:.:||.||:||:.
Zfish    65 GLSDNEIQKLPPDVANFTQLVELDISRNDISEIPENIKFCQSLEIADFSGNPLTRLPDGFTQLRG 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            |..|.|||:||.:||.|.|:|:.|.:|||||||||.||.::|.|.||::||||.|.:|.||..||
Zfish   130 LAHLSLNDVSLQSLPNDIGNLSNLVTLELRENLLKSLPSSLSFLVKLEQLDLGSNVLEVLPDTLG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .||.|.|||||.|||..||||||.|.:|..||||||||.|||.|||||::||||.|::||||.||
Zfish   195 ALPNLRELWLDRNQLSSLPPELGNLRQLVCLDVSENRLSELPTEISGLIALTDLLLSENLLEILP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            |.|..|.:|:|||::||||..|.|::|.|||:.||:||||.|..||.|:|::.||.|||||||.|
Zfish   260 DSIGSLKKLSILKVNQNRLVHLTDSIGECENLTELMLTENLLQSLPRSLGKLKKLTNLNVDRNRL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            ..:|.|:|.|.:|.|||||||:|.||||||.|.|.||||||:||:|..||::|.||.|||:||:|
Zfish   325 SSVPAELGGCVSLNVLSLRDNRLGKLPPELANATELHVLDVAGNRLQNLPFALANLNLKAMWLAE 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSE-PFEEREPSRT------VV 448
            |||||:|.||.:.|.:|||:||:|||||||      |:..||:..| ..:|..|:.|      |:
Zfish   390 NQSQPMLKFQTEDDEQTGEKVLTCYLLPQQ------PSSSLENLLERSVDEAWPTDTNLNRVSVI 448

  Fly   449 KFSEEATQEKETP---------FVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKL 504
            :|.:::..|:|..         ..|:.||||.:|  |..|..:|..|||.:   ...|:|:
Zfish   449 QFRDDSKHEEEDDETAADKRQGLQRRATPHPSEL--KVMKNVIEARRNEAY---TARPDED---- 504

  Fly   505 AETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQG-GSEGASSTANN 568
            .|:|.......:....|.|..|               ..:.||:..:....|| .|.|.......
Zfish   505 LESPDAEEKRLSGLSNQSHDSQ---------------ASSSTTSATSHEDKQGINSTGVELNDGQ 554

  Fly   569 VKAATAAVVAELAAT-----------VGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPP 622
            |:........|:..|           :.|.||..|.|..:|:.|....|     .:...|.....
Zfish   555 VQEEEDLDEMEVEYTEPTVHFAEEPIIRGGDEDDDYDNDDDDAERSDEV-----SQTPSFPAEKQ 614

  Fly   623 KLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDT--TPQHSLSGKVTSPIEEEEQLEVE 685
            :|.|:||||:.|:.::..|...:....|....:....:.|  ||::...|:   ..||||:.|.|
Zfish   615 RLIRKDTPHYKKHFKITKLPKPETVAALLQGFSHDGLSPTAHTPENERDGE---DDEEEEEDEDE 676

  Fly   686 QEQQQQQQQHPFD-------------SSLSPISAGKTAEASTDPDNLDGVTELRLEQYE--IHIE 735
            ::......||..|             |||.|:..     .|.|..|...:...|:|:.|  :.|.
Zfish   677 EDDLHTPFQHRLDAAELEDIRMSQMNSSLQPVKG-----VSFDQVNNLLIEPARIEEEELTLSIL 736

  Fly   736 RTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAV 800
            |...|||:||||||||||:||||:|||||||:|.|||..||:|||||:::|||:.:..|:|:.||
Zfish   737 RQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVKVGDKLLEVNGVDLHGAEHHTAV 801

  Fly   801 QVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEI 865
            :.|:..||.:|:.|.||  |:: .|         :.::.|.||
Zfish   802 EALRNSGAAVVMTVLRE--RMV-EP---------ENAITTTPL---------------------- 832

  Fly   866 VPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHT 930
            .|:..:..::::.           ||    .|.......||||..|..             :|.|
Zfish   833 RPEDDYFPRERRS-----------SG----LPFLLDPDCPAVSTGPAQ-------------RLAT 869

  Fly   931 TLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEA 995
            .|||:.  :||||||||||||..::....|||||||.|||.|:||..:.|||||::|||.|||||
Zfish   870 CLIRND--KGLGFSIAGGKGSTLYRVGDTGIFISRIAEGGAAHRDNILQVGDRVISINGVDMTEA 932

  Fly   996 HHDAAVACLTEPQRFVRLVLQREYR--GPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEV 1058
            .||.|||.||.....:.||:.||..  |...|.|.|.||
Zfish   933 RHDQAVALLTGTSPTITLVVDREQSSVGGASPRTRPHSP-------------------------- 971

  Fly  1059 EQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVP 1123
                         |.|:|:
Zfish   972 -------------PPPEPS---------------------------------------------- 977

  Fly  1124 MGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVN 1188
                          ||.|.:                     .||.:|              :..:
Zfish   978 --------------DSPEQE---------------------DGGDEH--------------LGNH 993

  Fly  1189 VNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSI 1253
            :|.|..|  .:|.                                    |||.|.|..|.||.||
Zfish   994 LNCPMED--EYPI------------------------------------EEVTLIKAGGPLGLSI 1020

  Fly  1254 IGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPG 1318
            :||:||:..|||..|||:|||.::|.|:||:.| ||:|||||:||..|:..||||:||..||...
Zfish  1021 VGGSDHASHPFGINEPGVFISKVIPNGLASQSG-LRVGDRILEVNSIDLRHATHQEAVRALLSNK 1084

  Fly  1319 DEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARR 1383
            .||::.::.||.|||.||:::.|..||:||:.|:||..|..|||.||:|||:|:||::|.|||.|
Zfish  1085 QEIRMLVRRDPSPPGMQEIVIHKQPGEKLGISIRGGAKGHAGNPFDPTDEGIFISKVSSNGAAAR 1149

  Fly  1384 DGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGF- 1447
            ||||:||||:|||..:||||.:|.:||.|||.:|:.:.:::|.|:|..:........|.::..|
Zfish  1150 DGRLRVGMRILEVGNNSLLGMTHTEAVRVLRASGDSLVMLICDGFDPKSASTIEASPGVIANPFA 1214

  Fly  1448 ------NSSASCSGGSRQGS--------RASETGSELSQ-------------------------- 1472
                  ||..|.|...|..|        :..|...|.||
Zfish  1215 AGIVRKNSMESISSVDRDLSPEEIDIMQKEVEMVRETSQWEREEMEKVERMRLEREEATRLLEEE 1279

  Fly  1473 SQSVSS----LDH-----------EEDERLRQDFDVFASQKPDAQQPTGP----SVLAAAAAMVH 1518
            ::|:||    ||:           ::..|....|..||  |.:|..|.||    ......|:|.|
Zfish  1280 TESLSSGPLKLDYKTLAALPTTSLQKVNRFSPSFSTFA--KMEAAMPAGPVDPLGFEKVHASMYH 1342

  Fly  1519 G-----ASSPTPPAATSNITPLPTAAA-------------------------------VASAD-- 1545
            .     .|||..|||:|..:..|.|.:                               ||:..
Zfish  1343 VEPVALPSSPICPAASSAASKQPQADSRDLVLDLGMAQEEEECLVDSQPICFSENPFLVANRKGK 1407

  Fly  1546 --------LTAP--------------------------DTPATQTVALIHAEQQAHQQQQQTQLA 1576
                    |:.|                          |:|........|..||:|:...    |
Zfish  1408 GCPPEERILSGPPVGYGKHGQLQPWLYSKASPSEPFRIDSPVRDAAHSPHNSQQSHKSSS----A 1468

  Fly  1577 PLGQE-----------KSTQEKVLEIVRAADAFTTV-PPKSPSE---HHEQDKIQKTTTVVISKH 1626
            .||:|           .:|::.......|....:.| ||.||:.   |...:..|...:.:.|:
Zfish  1469 MLGREVRYSNIHFPSNANTKDNASTKPGAIQPLSRVRPPVSPASQDGHSSPNPFQHGLSPINSQ- 1532

  Fly  1627 TLDTNPTTPTTP--------------------AAPLSIAGAESANSAGAPSPAVPASTP------ 1665
                  |||..|                    |.|.|:|..|......:|...|.|..|
Zfish  1533 ------TTPRAPSPDTHEEYPINIKQVYKAFAAVPHSLAVLEPPQDLYSPRNNVSAKQPSPEFQP 1591

  Fly  1666 --------------GSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTP-ASRDGAEEQQEEVRAK 1715
                          ||.|            ..|...|..|...|.:.| .||...|.:......:
Zfish  1592 ELNNEVFMDECDGEGSGP------------RPSLLSDRSEYRSLAAVPRLSRPSVEPKTPSPLGR 1644

  Fly  1716 PTPTKVPKSVSDKKRFFESAMEDQ--HKPTQKTDKVFSFLSKDEVEKLRQEEERKIATLRRDKNS 1778
            .:|.:  :|..|::::||..::.|  .||..:    .|.:.:|:::|:::||.::|
Zfish  1645 HSPEQ--RSFKDRQKYFEIDVKQQTPDKPKPR----ISLVGEDDLKKMKEEEAKRI--------- 1694

  Fly  1779 RLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVDNAALGHFDDAEDMRTAQS 1843
                           :||.:....     |.|:.::||.:|:                      .
Zfish  1695 ---------------EQRAREFML-----DEDEEEEEEDLAK----------------------Q 1717

  Fly  1844 LASTMPHAPSKIPKQKLKAKQIESSLPTPTA---LDPPKPSLLPKPKVKVVIPPALQQRLKQQQV 1905
            :|....|....:...:.|.:    ||.:||:   ..||..|..|........|.::..:...|:
Zfish  1718 VAHMKAHGKVVLDGVEYKVE----SLGSPTSRQCATPPNYSATPPSHCGSSGPSSIDGKGDSQR- 1777

  Fly  1906 QQQQQQHQQSQPEEPSIPEEEYHQQPEPDS-----PSAAGGSRIPVRTLKAERRALTLAARQSGL 1965
                           :..|:.:..:..|:|     |...|.|..|:||.|||||      .|..|
Zfish  1778 ---------------NSVEDSFRLEQRPNSMTGLIPVYPGESAAPIRTAKAERR------HQDRL 1821

  Fly  1966 SVEEYLKRLETQDDKE-SPASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVE-AQDVIKNM- 2027
            .::.  ..|....||| |||        .:..:.|||||.|||||...||:...: .||:.|.:
Zfish  1822 RMQS--PELTVALDKELSPA--------EKRALEAEKRAMWRAARPYGLEEDVRQYEQDLAKRLY 1876

  Fly  2028 -----RKMTDDLITHESRASEVETCKERIISLELQVPETE------DEGKLDDTQPPLELEADDF 2081
                 ..:........|..|...:|:.|:.|||....:.:      .|||...|...|
Zfish  1877 QSRVRASLGSAAAPASSSCSSSSSCQPRMKSLEQDALKAQMVIAKSKEGKKRGTLDQL------- 1934

  Fly  2082 QDDEDDDDDDDDEDDFEDEDEEEDTASIVTVQANNEKLFLRHDSDTYGPSSIESVASGKVRIKPT 2146
                                                       |::..|:...|         ||
Zfish  1935 -------------------------------------------SESPSPAPTPS---------PT 1947

  Fly  2147 PLSLHQTLAKETTIVEVLNPVIGGDGSARTIHVSGGLPFDEDAFEQGAVAVLRSETFVL----PG 2207
            |:.                     |.|.||:...|.|...|..|:....|.:.|...|.    ||
Zfish  1948 PME---------------------DISPRTVTSPGRLSLSEKKFDYRQFAAIPSSKPVYDIQSPG 1991

  Fly  2208 AAGGGR--SELSLNA----------KMKTVLEE--LLENERVKLNLQKSLE 2244
            ||....  .|.|.||          ...:.|||  |..|:|.....::|||
Zfish  1992 AADDVHFMDESSSNAVSVIDPEVPVAATSALEEMALYSNKRKLRQGRRSLE 2042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	176/269 (65%)
		leucine-rich repeat	18..38	CDD:275380	14/19 (74%)
		LRR_8	37..95	CDD:290566	43/57 (75%)
		leucine-rich repeat	39..61	CDD:275380	16/21 (76%)
		leucine-rich repeat	62..84	CDD:275380	17/21 (81%)
		LRR_8	84..138	CDD:290566	32/53 (60%)
		leucine-rich repeat	85..107	CDD:275380	14/21 (67%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	33/57 (58%)
		leucine-rich repeat	131..153	CDD:275380	12/21 (57%)
		leucine-rich repeat	154..176	CDD:275380	14/21 (67%)
		leucine-rich repeat	177..199	CDD:275380	12/21 (57%)
		LRR_8	198..256	CDD:290566	40/57 (70%)
		leucine-rich repeat	200..222	CDD:275380	16/21 (76%)
		leucine-rich repeat	223..245	CDD:275380	17/21 (81%)
		LRR_8	267..325	CDD:290566	34/57 (60%)
		leucine-rich repeat	269..289	CDD:275380	11/19 (58%)
		leucine-rich repeat	292..314	CDD:275380	11/21 (52%)
		leucine-rich repeat	315..337	CDD:275380	13/21 (62%)
		LRR_4	337..375	CDD:289563	26/37 (70%)
		leucine-rich repeat	361..382	CDD:275380	13/20 (65%)
		PDZ	728..816	CDD:214570	51/89 (57%)
		PDZ_signaling	931..1016	CDD:238492	50/84 (60%)
		PDZ	1239..1329	CDD:214570	47/89 (53%)
		PDZ_signaling	1336..1425	CDD:238492	48/88 (55%)
scrib	XP_021333089.1	leucine-rich repeat	14..37	CDD:275380	16/22 (73%)
		LRR	<37..306	CDD:227223	172/268 (64%)
		leucine-rich repeat	38..60	CDD:275380	15/21 (71%)
		leucine-rich repeat	61..83	CDD:275380	16/21 (76%)
		leucine-rich repeat	84..106	CDD:275380	14/21 (67%)
		leucine-rich repeat	107..129	CDD:275380	13/21 (62%)
		leucine-rich repeat	130..152	CDD:275380	11/21 (52%)
		leucine-rich repeat	153..175	CDD:275380	13/21 (62%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		LRR	<192..458	CDD:227223	157/272 (58%)
		leucine-rich repeat	199..221	CDD:275380	15/21 (71%)
		leucine-rich repeat	222..248	CDD:275380	18/25 (72%)
		leucine-rich repeat	268..290	CDD:275380	11/21 (52%)
		leucine-rich repeat	291..313	CDD:275380	12/21 (57%)
		leucine-rich repeat	314..336	CDD:275380	13/21 (62%)
		leucine-rich repeat	360..380	CDD:275380	12/19 (63%)
		PDZ_signaling	739..816	CDD:238492	47/76 (62%)
		PDZ_signaling	875..952	CDD:238492	24/76 (32%)
		PDZ_signaling	1004..1092	CDD:238492	15/89 (17%)
		PDZ_signaling	1102..1191	CDD:238492	6/88 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I3704
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	753	1.000	Inparanoid score	I541
OMA	1	1.010	-	-		QHG48681
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	1	1.000	-	-		FOG0005473
OrthoInspector	1	1.000	-	-		oto41320
orthoMCL	1	0.900	-	-		OOG6_102427
Panther	1	1.100	-	-	LDO	PTHR23119
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2604
SonicParanoid	1	1.000	-	-		X5064
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.000