DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrrc1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001014290.1	Gene:	Lrrc1 / 367113	RGDID:	1549773	Length:	524	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	283/505 - (56%)
Similarity:	363/505 - (71%)	Gaps:	17/505 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            ||.|||::: |||.||.:|||||||..|||||.||:|:||||.||||.:|:||:.||:|.:||||
  Rat     1 MFHCIPLWR-CNRHVEAIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            ||||||:.||||:|.||..||||||||||||:||:.|...::|||||||.||:.:||..|.:|:|
  Rat    65 GLSDNEVQRLPPEIANFMQLVELDVSRNDIPEIPESISFCKALQVADFSGNPLTRLPESFPELQN 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            ||.|.:||:||.:||.:.|:|..|.|||||||||.:||::::||.:|:.||||:|||..||..:|
  Rat   130 LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYSLPESIG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .|..|.:||||.|||..||.|:|.|..|..|||||||||.||.|||||:|||||.::|||||.:|
  Rat   195 ALLHLKDLWLDGNQLSELPQEIGNLRNLLCLDVSENRLERLPEEISGLISLTDLVVSQNLLETVP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            |||.||.:|:|||||||||.:|.:.:|:|||:.||:||||.|..||.|||::.||||||.|||.|
  Rat   260 DGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPTSIGKLKKLNNLNADRNKL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            ..||.|||.|.:|.|..:|||:|.::|.|:.....||||||:||:|.:||.||..|:|||:|||:
  Rat   325 VSLPKEIGGCCSLTVFCIRDNRLTRIPSEVSQAMELHVLDVAGNRLHHLPLSLTTLKLKALWLSD 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPIT--------PARDLESD--SEPFEEREPSR 445
            ||||||||||.|.|..|||::|:|.||||...:||.        ....|.:|  .|.:::....|
  Rat   390 NQSQPLLTFQTDVDHTTGEKILTCVLLPQMPSEPICQESLPRCGAMESLVNDVSEEAWDDHSVHR 454

  Fly   446 -TVVKFSEEATQEKET---PFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491
             :.::|.|:...|:|.   ...|:.||||.:|  |..|..||..||:.:|
  Rat   455 VSAIRFLEDEKDEEENQTRTLQRRATPHPGEL--KNMKKTVENLRNDMNA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	171/269 (64%)
		leucine-rich repeat	18..38	CDD:275380	14/19 (74%)
		LRR_8	37..95	CDD:290566	41/57 (72%)
		leucine-rich repeat	39..61	CDD:275380	14/21 (67%)
		leucine-rich repeat	62..84	CDD:275380	17/21 (81%)
		LRR_8	84..138	CDD:290566	32/53 (60%)
		leucine-rich repeat	85..107	CDD:275380	15/21 (71%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	32/57 (56%)
		leucine-rich repeat	131..153	CDD:275380	11/21 (52%)
		leucine-rich repeat	154..176	CDD:275380	14/21 (67%)
		leucine-rich repeat	177..199	CDD:275380	12/21 (57%)
		LRR_8	198..256	CDD:290566	37/57 (65%)
		leucine-rich repeat	200..222	CDD:275380	13/21 (62%)
		leucine-rich repeat	223..245	CDD:275380	17/21 (81%)
		LRR_8	267..325	CDD:290566	36/57 (63%)
		leucine-rich repeat	269..289	CDD:275380	12/19 (63%)
		leucine-rich repeat	292..314	CDD:275380	12/21 (57%)
		leucine-rich repeat	315..337	CDD:275380	15/21 (71%)
		LRR_4	337..375	CDD:289563	17/37 (46%)
		leucine-rich repeat	361..382	CDD:275380	13/20 (65%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrrc1	NP_001014290.1	LRR_RI	33..232	CDD:238064	120/198 (61%)
		leucine-rich repeat	38..60	CDD:275380	14/21 (67%)
		LRR	39..412	CDD:227223	228/372 (61%)
		leucine-rich repeat	61..83	CDD:275380	17/21 (81%)
		leucine-rich repeat	84..106	CDD:275380	15/21 (71%)
		leucine-rich repeat	107..129	CDD:275380	13/21 (62%)
		leucine-rich repeat	130..152	CDD:275380	11/21 (52%)
		leucine-rich repeat	153..175	CDD:275380	14/21 (67%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		leucine-rich repeat	199..221	CDD:275380	13/21 (62%)
		leucine-rich repeat	222..244	CDD:275380	17/21 (81%)
		leucine-rich repeat	245..290	CDD:275380	28/44 (64%)
		leucine-rich repeat	314..336	CDD:275380	15/21 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10749
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46308
orthoMCL	1	0.900	-	-		OOG6_102427
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720