DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Lap1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	255/912 - (27%)
Similarity:	414/912 - (45%)	Gaps:	165/912 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KCIPIFKGCNRQVEFVDKRHCS---LPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRK 64
            ||.|.||  .::.|.:||...|   |...| |:.::.||||||:|....::.||...|....||.
  Fly     6 KCFPCFK--FKREEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRV 67

  Fly    65 LGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLK 129
            |.::.|.:..:|..|.:...|..||::||.|.::|::||..:.|...|.|.|.:.:||...:.|.
  Fly    68 LHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLI 132

  Fly   130 NLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYL 194
            :|..|.||:..|..|||:||.|..|..||||.|.|..||:::.:|..|:|||:|.||..:||..:
  Fly   133 SLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVV 197

  Fly   195 GYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEAL 259
            |.|..|.|||:|.||::|:...:|.|..|.:.:.:.|.|:.||:|:|...::..|.:..|.|||.
  Fly   198 GELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAF 262

  Fly   260 PDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNA 324
            |..:..|..|...|.:.|.|..|.|::...|.::||:|:.|.|..||::||.:..|..|..|.|.
  Fly   263 PFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQ 327

  Fly   325 LEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWL 388
            |..||.|:..|..|.|||:.:|:|..||..:||.:.:.||:|..|.:..||.|::|| .|.::||
  Fly   328 LRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWL 392

  Fly   389 SENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEERE----------- 442
            |:||||||:..| ..||.|..| |:|::|||..::    ...:::..:..|:.|
  Fly   393 SDNQSQPLVPLQ-YLDASTKTQ-LTCFMLPQVTFK----MNSIQAQQQAQEQYEFVYANQQQPHA 451

  Fly   443 -PSRTVVKFSEEAT---QEKETP------------------------FVRQNTPHPKDLK----- 474
             |||.:. |:||||   ..|..|                        .:|..||:||:|:
  Fly   452 SPSRRIC-FAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKY 515

  Fly   475 --------AKAQKLKVERSR---------NEEHANLVTLPEENGTKLAETPTETRTIANNHQQ-- 520
                    :.|...:|..:|         :..:||...:.:...:.:.....||..|...:||
  Fly   516 VRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAPETTHIYGVYQQPQ 580

  Fly   521 ---QPHPVQQ----PIVGVNSK-QPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVV 577
               .|.|.|:    |:|...:. |.:.|...||..||
  Fly   581 QMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPLPTT---------------------------- 617

  Fly   578 AELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPP----KLHRRDTPHHL----- 633
                         ..:.:|:.|.:..::...|.:.......:.||    :::.:.||..|
  Fly   618 -------------HLNGDQDYELQPLQQQPMQQQALPTPRLEPPPYHIARVYTKKTPEDLNLYES 669

  Fly   634 --KNKRVQHLTDK--------QASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQ 688
              :.|:.|.|.::        ..|.....|:.:|:..::..|......:::.:|...: |.:||.
  Fly   670 MRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNISNNLEPNPE-EEDQEL 733

  Fly   689 QQQQQQHPFDSSLSPISAGKTAEASTDPDN-LDGV-TELRLEQYEIHIERTAAGLGLSIAGGKGS 751
            .....||    ||:..:...|::||..... :.|| ....::|..:..|.:   :|..||.....
  Fly   734 DDTMSQH----SLNSTATNNTSKASHKKSTWIFGVHKNPTVKQVTLKWENS---IGFDIAELLNQ 791

  Fly   752 TPFKGDDDGIFISRVT-EAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQ 815
            .       |||:|.:| ....|.|  |.:.||:::::|..:.:|:...|.:||..||.|:.:::.
  Fly   792 V-------GIFVSSITPNTNAARL--LNLNDKLLEIDGYDLTNANLSDAKRVLLNCGTVMNIMLS 847

  Fly   816 RE 817
            |:
  Fly   848 RK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	99/272 (36%)
		leucine-rich repeat	18..38	CDD:275380	6/22 (27%)
		LRR_8	37..95	CDD:290566	21/57 (37%)
		leucine-rich repeat	39..61	CDD:275380	8/21 (38%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	19/53 (36%)
		leucine-rich repeat	85..107	CDD:275380	9/21 (43%)
		leucine-rich repeat	108..130	CDD:275380	7/21 (33%)
		LRR_8	129..187	CDD:290566	27/57 (47%)
		leucine-rich repeat	131..153	CDD:275380	11/21 (52%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	11/21 (52%)
		LRR_8	198..256	CDD:290566	19/57 (33%)
		leucine-rich repeat	200..222	CDD:275380	10/21 (48%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	20/57 (35%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	9/21 (43%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	14/37 (38%)
		leucine-rich repeat	361..382	CDD:275380	9/21 (43%)
		PDZ	728..816	CDD:214570	23/88 (26%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	68/179 (38%)
		leucine-rich repeat	21..41	CDD:275380	5/20 (25%)
		LRR_8	40..98	CDD:290566	21/57 (37%)
		leucine-rich repeat	42..64	CDD:275380	8/21 (38%)
		leucine-rich repeat	65..87	CDD:275380	6/21 (29%)
		LRR_8	86..140	CDD:290566	18/53 (34%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		leucine-rich repeat	111..133	CDD:275380	7/21 (33%)
		leucine-rich repeat	134..156	CDD:275380	11/21 (52%)
		LRR_8	156..213	CDD:290566	27/56 (48%)
		leucine-rich repeat	157..179	CDD:275380	10/21 (48%)
		leucine-rich repeat	180..202	CDD:275380	11/21 (52%)
		leucine-rich repeat	203..225	CDD:275380	10/21 (48%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	6/21 (29%)
		LRR_8	279..328	CDD:290566	18/48 (38%)
		leucine-rich repeat	295..317	CDD:275380	9/21 (43%)
		leucine-rich repeat	318..340	CDD:275380	9/21 (43%)
		LRR_8	340..396	CDD:290566	23/55 (42%)
		leucine-rich repeat	364..386	CDD:275380	9/21 (43%)
		PDZ_signaling	770..846	CDD:238492	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46761
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820