DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and Scrib

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001178808.1 Gene:Scrib / 362938 RGDID:1565055 Length:1663 Species:Rattus norvegicus


Alignment Length:2244 Identity:742/2244 - (33%)
Similarity:1016/2244 - (45%) Gaps:679/2244 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            |.||||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||||..||||
  Rat     1 MLKCIPLWR-CNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||||.||||::.||..||||||||||||:||:.||..::|::||||.||:.:||.||:||::
  Rat    65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            |..|.|||:||..||.|.|:|..|.:|||||||||.||.::|.|.||::||||.|::|.||..||
  Rat   130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .||.|.|||||.|||..||||||.|.:|..||||||||||||.|:.||..||||.|:||||:.||
  Rat   195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            :||.:|.:|:|||:|||||..:.:.:|:|||:.|||||||.|:.||.|:|::|||.|||||||.|
  Rat   260 EGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPRSLGKLTKLTNLNVDRNHL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            |.||.|||.|..|.|||||||:|..|||||.:...||||||:||:|..||::|.:|.|||:||:|
  Rat   325 EVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHLNLKALWLAE 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSR-TVVKF---- 450
            ||:||:|.||.:.||:|||:||:|||||||....:.......|.||...:...|| :|::|    
  Rat   390 NQAQPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDPGQQSSPSESCSDAPLSRVSVIQFEDPL 454

  Fly   451 -----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTE 510
                 :|||..||. ...|:.||||.:|  |..|..:|..|||.   .|..|:.:....:|   |
  Rat   455 EGEEDAEEAAAEKR-GLQRRATPHPSEL--KVMKRGIEERRNEA---FVCKPDPSPPSPSE---E 510

  Fly   511 TRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAA 575
            .|.::                                   |.:.:.|.|..::|||::.:..|  
  Rat   511 ERRLS-----------------------------------AESALSGNSVPSASTASDGEPET-- 538

  Fly   576 VVAELAA-----TVGGSDEVQDDDEQED--EFESD----RRVGFQVEGEDDDFYKRP---PKLHR 626
            :.||:..     .:.|.:|..::|..|.  .|..|    |..|...||:.:..:..|   .:|.|
  Rat   539 LPAEVQGLGQQEAMPGQEEYPEEDYNEPTVHFAEDTLIPREDGEGEEGQPEAPWPLPSGRQRLIR 603

  Fly   627 RDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSP--IEEEEQLEVEQEQQ 689
            :||||:.|:.::..|...:|...|...:.:.....|...|:......:|  .||||:.|...|::
  Rat   604 KDTPHYKKHFKISKLPQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEEEENRDEEE 668

  Fly   690 QQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYE--IHIERTAAGLGLSIAGGKGST 752
            .:......|...:..||......|.|..|...:...|:|:.|  :.|.|...|||:|||||||||
  Rat   669 GEASMEEDDKEEAVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIAGGKGST 733

  Fly   753 PFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQRE 817
            |:||||:|||||||:|.|||..||::||||:::|||:.:.||:|::||:.|:..||.:.:.|.||
  Rat   734 PYKGDDEGIFISRVSEEGPAAHAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQMRVWRE 798

  Fly   818 VTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQ 882
              |:: .|         :.:|...||                                  :|...
  Rat   799 --RMV-EP---------ENAVTITPL----------------------------------RPEDD 817

  Fly   883 VAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTT-LIRDQIGQGLGFSIA 946
            .:| ..:.|.....|    .:||              |.|:...|.|.. |:|.:  :|||||||
  Rat   818 YSP-REWRGGGLRLP----LLQP--------------ETPVPLRQRHAACLVRSE--KGLGFSIA 861

  Fly   947 GGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFV 1011
            |||||.|::....|||||||.|||.|:|.|.:.|||||::|||.|||||.||.||:.||.....:
  Rat   862 GGKGSTPYRAGDAGIFISRIAEGGAAHRAGTLQVGDRVLSINGVDMTEARHDHAVSLLTAASTTI 926

  Fly  1012 RLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKP 1076
            .|:|:||..|...|...|.|                                     ::|||   
  Rat   927 SLLLERETGGAYPPSPPPHS-------------------------------------SSTPT--- 951

  Fly  1077 TVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGE 1141
                                 ||.||....:..|:|: .||                        
  Rat   952 ---------------------ATVAATMTTAIPGEPL-LPR------------------------ 970

  Fly  1142 AQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTEL 1206
            ..||.|             |..|.|                         |.|            
  Rat   971 LSPSLL-------------ATALEG-------------------------PYP------------ 985

  Fly  1207 GRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGI 1271
                                          .||:.||:..|.||.||:||:|||..|||.::||:
  Rat   986 ------------------------------VEEICLPRAGGPLGLSIVGGSDHSSHPFGVQDPGV 1020

  Fly  1272 FISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQE 1336
            |||.::|.|:|::|| ||:|||||.||..||.:||||:||..||:|..|:.|.::.||.|||.:|
  Rat  1021 FISKVLPRGLAARCG-LRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPPPPGMRE 1084

  Fly  1337 VLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSL 1401
            :.:.||.||:||:.|:||..|..|||.||:|||:|:||::..|||.|||||:||:||||||..||
  Rat  1085 LCIQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSL 1149

  Fly  1402 LGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASET 1466
            ||.:|.:||.:||:.|:.:.::||.|:|.|..     .|..:|.|..::...:|...:.|     
  Rat  1150 LGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTT-----TALEVSPGVIANPFAAGLGHRNS----- 1204

  Fly  1467 GSELSQSQSVSSLDHE--------EDERLRQDFDVFASQ----KPDAQQPTGPS---------VL 1510
                  .:|:||:|.|        |.|        .|||    :|::.:.||.:         ||
  Rat  1205 ------LESISSIDRELSPEGPGKEKE--------LASQTLPWEPESAETTGRNQEPLKLDYRVL 1255

  Fly  1511 AAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTV--ALIHAEQQAHQQQQQT 1573
            ||           .|.|.:....|..|.....:   .||.:|.:|..  .:|....||..:... 
  Rat  1256 AA-----------VPSAGSLQRGPCATTGGKMT---EAPSSPGSQQTKPGVIQPLAQAWPRDSP- 1305

  Fly  1574 QLAPLGQE-----KSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPT 1633
              ||.|::     .|..|....:.:|..||..||...|.|:                     :.|
  Rat  1306 --APRGRDGPCSPPSPDELPANVKQAYRAFAAVPTVHPPEN---------------------SAT 1347

  Fly  1634 TPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQST 1698
            .|.||.                     ||::|                           .||   
  Rat  1348 QPPTPG---------------------PAASP---------------------------EQL--- 1361

  Fly  1699 PASRDGAEEQQEEVRAKPTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQ 1763
                                     |..:::::||  :|.:....:...|..|.:..|::.|:::
  Rat  1362 -------------------------SFRERQKYFE--LEVRVPQAEGPPKRVSLVGADDLRKMQE 1399

  Fly  1764 EEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVDNAA 1828
            ||.||:    :.|.:::|                                :||.:..|...    
  Rat  1400 EEARKL----QQKRAQML--------------------------------REEAVTSGPDT---- 1424

  Fly  1829 LGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLLPKPKVKVVIP 1893
                          .|||                                               
  Rat  1425 --------------GLAS----------------------------------------------- 1428

  Fly  1894 PALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQQP----------EPDSPSAAGGSRIPVRT 1948
                                    :..|:.:|:..:||          .|.||:..||| .||||
  Rat  1429 ------------------------DRESLDDEQEAEQPWAGPSHAGGLSPSSPTPLGGS-APVRT 1468

  Fly  1949 LKAERRALTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEKRASWRAARLRSL 2013
            .|||||               :.:||..| ..|.||.....:...|..:.|||||.|||||::||
  Rat  1469 AKAERR---------------HQERLRMQ-SPELPAPERALSPAERRALEAEKRALWRAARMKSL 1517

  Fly  2014 EQGAVEAQDVIKNMRKMTDDLITHESRASEVETCKERIISLELQVP-----ETEDEGKLDDTQP- 2072
            ||.|:.||.|:..         :.|.|......  ||:.......|     ..||.|....|.| 
  Rat  1518 EQDALRAQMVLSK---------SQEGRGKRGPL--ERLAEAPSPAPTPSPTPLEDFGLQTSTSPG 1571

  Fly  2073 --PLELEADDFQ------------DDEDDDDDDD----DEDDFEDEDEEEDTASIVTVQANNEKL 2119
              ||..:..|::            |.:..|..::    |........||:...::|        |
  Rat  1572 RLPLSGKKFDYRAFAALPSSRPVYDIQSPDFVEELRTLDPSPSPGPQEEDGEVALV--------L 1628

  Fly  2120 FLRHDSDTYGP------SSIESVASGKVRIKPTP 2147
            ..|....|.||      ||..::..|:..:.|.|
  Rat  1629 LGRPSPGTVGPEDMTLCSSRRAMRPGRRGLGPVP 1662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 177/269 (66%)
leucine-rich repeat 18..38 CDD:275380 16/19 (84%)
LRR_8 37..95 CDD:290566 43/57 (75%)
leucine-rich repeat 39..61 CDD:275380 16/21 (76%)
leucine-rich repeat 62..84 CDD:275380 17/21 (81%)
LRR_8 84..138 CDD:290566 32/53 (60%)
leucine-rich repeat 85..107 CDD:275380 16/21 (76%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
LRR_8 129..187 CDD:290566 33/57 (58%)
leucine-rich repeat 131..153 CDD:275380 12/21 (57%)
leucine-rich repeat 154..176 CDD:275380 14/21 (67%)
leucine-rich repeat 177..199 CDD:275380 12/21 (57%)
LRR_8 198..256 CDD:290566 40/57 (70%)
leucine-rich repeat 200..222 CDD:275380 16/21 (76%)
leucine-rich repeat 223..245 CDD:275380 16/21 (76%)
LRR_8 267..325 CDD:290566 35/57 (61%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 12/21 (57%)
leucine-rich repeat 315..337 CDD:275380 16/21 (76%)
LRR_4 337..375 CDD:289563 23/37 (62%)
leucine-rich repeat 361..382 CDD:275380 12/20 (60%)
PDZ 728..816 CDD:214570 50/89 (56%)
PDZ_signaling 931..1016 CDD:238492 48/85 (56%)
PDZ 1239..1329 CDD:214570 48/89 (54%)
PDZ_signaling 1336..1425 CDD:238492 48/88 (55%)
ScribNP_001178808.1 LRR_RI 12..232 CDD:238064 145/219 (66%)
leucine-rich repeat 14..37 CDD:275380 18/22 (82%)
leucine-rich repeat 38..60 CDD:275380 16/21 (76%)
LRR 39..405 CDD:227223 231/365 (63%)
leucine-rich repeat 61..83 CDD:275380 17/21 (81%)
leucine-rich repeat 84..106 CDD:275380 16/21 (76%)
leucine-rich repeat 107..129 CDD:275380 13/21 (62%)
leucine-rich repeat 130..152 CDD:275380 12/21 (57%)
leucine-rich repeat 153..175 CDD:275380 14/21 (67%)
leucine-rich repeat 176..198 CDD:275380 12/21 (57%)
leucine-rich repeat 199..221 CDD:275380 16/21 (76%)
leucine-rich repeat 268..290 CDD:275380 11/21 (52%)
LRR_4 289..329 CDD:289563 27/39 (69%)
leucine-rich repeat 291..313 CDD:275380 12/21 (57%)
leucine-rich repeat 314..336 CDD:275380 16/21 (76%)
leucine-rich repeat 360..381 CDD:275380 12/20 (60%)
PDZ 709..797 CDD:214570 49/87 (56%)
PDZ_signaling 852..931 CDD:238492 46/80 (58%)
PDZ_signaling 986..1074 CDD:238492 49/88 (56%)
PDZ_signaling 1083..1173 CDD:238492 48/89 (54%)
AbLIM_anchor 1563..>1657 CDD:292800 20/101 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 248 1.000 Domainoid score I2079
eggNOG 1 0.900 - - E33208_3BA7S
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48681
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 1 1.000 - - FOG0005473
OrthoInspector 1 1.000 - - otm46308
orthoMCL 1 0.900 - - OOG6_102427
Panther 1 1.100 - - LDO PTHR23119
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5064
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.830

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