DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Snta1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001094371.1	Gene:	Snta1 / 362242	RGDID:	1307068	Length:	499	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	110/512 - (21%)
Similarity:	174/512 - (33%)	Gaps:	135/512 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 AQTVQPA---VSAAPNGLLLNGREAP---------LSYIQLHTTLIRDQIGQGLGFSIAGGKGSP 952
            |.||.||   ....|....|||...|         ...:|.....:|.....|||.||.||
  Rat    39 ALTVSPADGEPGPEPEPAQLNGAAEPGAASPQLPEALLLQRRRVTVRKADAGGLGISIKGG---- 99

  Fly   953 PFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQR 1017
              :::...|.||:|.:|..|.:...:.|||.::::||.|::.|.||.||..|.:..:  .:||:.
  Rat   100 --RENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGK--EVVLEV 160

  Fly  1018 EYRGPLEP-------------PTSPRSPAVLNSLSPSGYLANRPANFSRSV-VEVEQPYKYNTLA 1068
            :|...:.|             .:.|.||......||    ..:|.|.:.:. |.::..|......
  Rat   161 KYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSP----GPQPRNLNEAKHVSLKMAYVSRRCT 221

  Fly  1069 TTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGS 1133
            .|.|.|:.....:....:.....:|....|.:.|..|
  Rat   222 PTDPEPRYLEICAADGQDTLFLRAKDEASARSWAGAI---------------------------- 258

  Fly  1134 TTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPM 1198
                   :||.|:..|...|:.||::.|.. :.|||....:....|               .||.
  Rat   259 -------QAQISTFIPWVKDELQALLTATG-TAGSQDIKQIGWLTE---------------QLPS 300

  Fly  1199 FPAAPTELGRVTE---------TITKSTFTETVMTRITDNQLAEPLISEEVV-LPKNQGS----- 1248
            ...||| |..:||         ..|:...:....|        .|||:..:| ...::||
  Rat   301 GGTAPT-LALLTEKELLLYCSLPQTREALSRPART--------APLIATRLVHSGPSKGSVPYDA 356

  Fly  1249 -LGFSIIGGTDHSCVP--FGTREP---GIFISHIVPGGIASKCGKLRMGDRILKV----NEADVS 1303
             |.|::..||.|....  |....|   ..:...:|.|     |.:...|.:.:..    |....:
  Rat   357 ELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDG-----CHRAAEGVQEVSTACTWNGRPCN 416

  Fly  1304 KATHQDA--VLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQ 1358
            .:.|.|.  .|...:|| ..:..:...|    |:::.:|..:|..|.....||..|:
  Rat   417 LSVHIDKGFTLWAAEPG-ATRAVLLRQP----FEKLQMSSDDGMSLLFLDFGGAEGE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	27/84 (32%)
		PDZ	1239..1329	CDD:214570	20/107 (19%)
		PDZ_signaling	1336..1425	CDD:238492	6/23 (26%)
Snta1	NP_001094371.1	PDZ_signaling	80..161	CDD:238492	28/88 (32%)
		PHsplit_syntrophin	<206..264	CDD:269960	11/92 (12%)
		PH	292..395	CDD:278594	26/131 (20%)
		PH	292..395	CDD:214574	26/131 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910