DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and metro

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	138/669 - (20%)
Similarity:	202/669 - (30%)	Gaps:	208/669 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 KRVQHLTDKQASEILANALASQERNDTTPQHSLSGKV-----TSPIEEEEQLEVEQEQQQQQQQH 695
            |..::|::.|..:.|...|.|:|.|.....|:...||     .:|: .....:|..|..:|..||
  Fly    24 KESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPV-LSTSAQVLYEVLEQLSQH 87

  Fly   696 PF-------------DSSLSPISAGKTAEASTD--PDNLDGVTELRLEQYEIHIERTAAGLGLSI 745
            ..             ||.|..:.....|.|..|  |...:...|:..::..|.|.:.... ...:
  Fly    88 CHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKS-NEPL 151

  Fly   746 AGGKGSTPFKG------DDDG-IFISRVTEAGPADLAGL-KVGDKVIKVNGIVVVDADHYQAVQV 802
            .|.:.:.|..|      ::.| |.|:|:...|.||.:|| .|||:||:||.|.|..
  Fly   152 TGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEG--------- 207

  Fly   803 LKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVP 867
             |..|.||.::...|.|...........|:..:..|..|            :|..|.|.....:|
  Fly   208 -KTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVR------------AHFDYNPDVDPYIP 259

  Fly   868 QQQ-----------HLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREA 921
            .::           |:..|......|....|..|...
  Fly   260 CKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARA---------------------------- 296

  Fly   922 PLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMA 986
                                                  |:..||      |.::.:|: .||...
  Fly   297 --------------------------------------GLIPSR------ALQERRIL-HDRTQK 316

  Fly   987 INGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSG--------- 1042
             ||.|:.......|..|.|                   ||.|||.||   |.|.|.
  Fly   317 -NGTDLDSKPGSCASLCTT-------------------PPGSPRLPA---SSSTSSCRQPKTKKI 358

  Fly  1043 -YLANRPANFSRSVVEVEQPYKYNTLATTTPTP---KPTVPASISNNNNTLPSSKTNGFATAAAA 1103
             |......:|.|     ||...|..:|...|.|   :|.|...       .|....|.......|
  Fly   359 MYDLTENDDFDR-----EQIATYEEVAKLYPRPGVFRPIVLIG-------APGVGRNELRRRLIA 411

  Fly  1104 TIDSSTGQPVP---APRRTNSV----------PMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDF 1155
            ........|||   .|.||..|          ...|.||.||...  :.||.: ..|...:::..
  Fly   412 RDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFV--EHGEYK-GHLYGTSAESV 473

  Fly  1156 QAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTE 1220
            ::::.|..:...|.|...:.......:....::| || |:|.:..|..      ||...||||.|
  Fly   474 KSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHV-KP-PELDILKATR------TEARAKSTFDE 530

  Fly  1221 TVMTRITDNQLAEPLISEE 1239
            ......||.:..:.:.|.|
  Fly   531 ANARSFTDEEFEDMIKSAE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	27/95 (28%)
		PDZ_signaling	931..1016	CDD:238492	13/84 (15%)
		PDZ	1239..1329	CDD:214570	1/1 (100%)
		PDZ_signaling	1336..1425	CDD:238492
metro	NP_610642.2	L27	17..68	CDD:197794	11/43 (26%)
		L27	75..127	CDD:197794	12/51 (24%)
		PDZ_signaling	139..229	CDD:238492	29/100 (29%)
		SH3_MPP	243..302	CDD:212796	11/136 (8%)
		Guanylate_kin	390..575	CDD:279019	40/178 (22%)
		GuKc	399..580	CDD:214504	37/162 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910