DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lnx1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	123/547 - (22%)
Similarity:	198/547 - (36%)	Gaps:	175/547 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   939 QGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVAC 1003
            :.|...:.||..:|...     |.|..|...|:..|||:::.||.::.:||.|::...|:.||..
  Rat   288 ESLSIRLVGGSETPLVH-----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRL 347

  Fly  1004 LTEPQRFVRLVLQREYR------GPLEPPTSPRSPA---VLNSLSPSGYLANRPANFSRSVVEVE 1059
            |.:|.:.:||.:.||.:      .|......||..:   :||..||...|.      .:.|..|:
  Rat   348 LRQPCQVLRLTVLREQKFRSRSNAPAPDSYGPRDDSFHVILNKSSPEEQLG------IKLVRRVD 406

  Fly  1060 QP--YKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSV 1122
            :|  :.:|.|                           ||........::.:          ...:
  Rat   407 EPGVFIFNVL---------------------------NGGVADRHGQLEEN----------DRVL 434

  Fly  1123 PMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTV 1187
            .:...|:..||..|.                       ||.:. .|:.:||:         .|:.
  Rat   435 AINGHDLRFGSPESA-----------------------AHLIQ-ASERRVHL---------VVSR 466

  Fly  1188 NVNKPQPDLPMFPAA---------PTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLP 1243
            .|.:|.||:  |..|         |....|.|.:...:|..|.|::               |...
  Rat   467 QVRQPSPDI--FQEAGCISNGQQSPVSGERSTSSKPAATCHEKVVS---------------VQKD 514

  Fly  1244 KNQGSLGFSIIGGTDHSCVPFGTRE---PGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKA 1305
            .|: |||.::.||..|       ||   | |::..:.|||:.|:.|:::.||.:|.||..::::.
  Rat   515 PNE-SLGMTVGGGASH-------REWDLP-IYVISVEPGGVISRDGRIKTGDILLNVNGIELTEV 570

  Fly  1306 THQDAVLELLK--PGD------EIK------------LTIQHDPLPPG----------------- 1333
            :..:|| .:||  |..      |:|            |...|:..|||
  Rat   571 SRTEAV-AILKSTPSSVVLKALEVKEQETQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLY 634

  Fly  1334 -FQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVN 1397
             .::|:|.:.....||..|.||.....||      :..|:..|.....|..|||::.|..||.||
  Rat   635 NCKDVILRRNTAGSLGFCIVGGYEEYSGN------QPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693

  Fly  1398 GHSLLGASHQDAVNVLRNAGNEIQLVV 1424
            |.|..|..|.....:|:....:|.|.:
  Rat   694 GRSTSGMMHACLARMLKELKGKITLTI 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	23/76 (30%)
		PDZ	1239..1329	CDD:214570	31/112 (28%)
		PDZ_signaling	1336..1425	CDD:238492	27/89 (30%)
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	25/80 (31%)
		PDZ_signaling	276..360	CDD:238492	23/76 (30%)
		PDZ_signaling	384..464	CDD:238492	21/155 (14%)
		PDZ_signaling	506..589	CDD:238492	29/107 (27%)
		PDZ_signaling	637..721	CDD:238492	27/90 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910