DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and CG9044

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001260114.1	Gene:	CG9044 / 33825	FlyBaseID:	FBgn0031752	Length:	1318	Species:	Drosophila melanogaster

Alignment Length:	1260	Identity:	237/1260 - (18%)
Similarity:	417/1260 - (33%)	Gaps:	389/1260 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PEEILRYSRTLEE-----------LFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGR----LPPD 78
            |::|...:..|.:           |.|..:.:|.|..:|..        ::|.|||.    |.|
  Fly     3 PQKITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTL--------IADTEIGTGAGYLQP- 58

  Fly    79 IQNFENLVELDVSRNDIPD---IPDDIKHLQSLQVADFSSN-------PIPKLPSGFSQLKNLTV 133
             |:|:.:..::...:..||   :.|.::....|::..|.|.       .|.|    |..|:.|.|
  Fly    59 -QSFQVVKPINAKSSVFPDLQLVHDFVQKTTLLKLTYFPSEHYFEGAIDIAK----FRALRRLEV 118

  Fly   134 LGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDL-----GDNEIEDLPPY 193
            ..:|             :.|:..::.....|:|| ..:..||.:.  |:     |||.
  Fly   119 NKIN-------------IGQVVGIQPLRGQLQHL-ICVKSLTSVD--DIITRCGGDNS------- 160

  Fly   194 LGYLPGLHELW-------LDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDL 251
            .|:      :|       ..:|.|:.:...|.....|.:|::..|:|..:. .|..|..|..|||
  Fly   161 NGF------VWNELKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSVA-AIKWLPHLKTLDL 218

  Fly   252 AQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLN 316
            :.|.|..||               |..::.       |:.:|.|.::.|::.|| ..:.::..|.
  Fly   219 SYNCLTHLP---------------QFHMEA-------CKRLQLLNISNNYVEEL-LDVAKLDALY 260

  Fly   317 NLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL 381
            ||::..|.|    ||..|...|..|                 ..|.||::.||.|...|   .:.
  Fly   261 NLDLSDNCL----LEHSQLLPLSAL-----------------MSLIVLNLQGNPLACNP---KHR 301

  Fly   382 QLKAVWLSENQS--QPLLTFQPDTDAE---TGEQVLSCYLLPQQEYQPITPARDLE--------S 433
            |..|.:|.:|.:  :.:|.|:|.|.||   ||.|... |:.......|.:.:..:.        |
  Fly   302 QATAQYLHKNSATVKFVLDFEPLTKAEKALTGSQKWR-YISGLSHRSPRSTSMSINSSSASINTS 365

  Fly   434 DSEPFEEREPSRTV-VKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVT-- 495
            |...|......|:| ::......::.::....|::......|.:...::.....|.:.|::.|
  Fly   366 DGSQFSSFGSQRSVSIRGKNYTLEDNQSMDTSQSSKRISSCKIRTVDIEESSEINTDAASVSTPN 430

  Fly   496 ----LPEENGTKLAET--PTETRTIANNHQQQPHPVQQPIVGVNSKQPV-------------VVG 541
                ..||......||  ..||..:...::.......:.::|:.:.||.             .:|
  Fly   431 PRSEYEEEPDNSHLETKKKIETLRLTYGNEWLKSGNAELMLGIETPQPTERERNESRQLFNEYLG 495

  Fly   542 VVTPTTTTVAPTGVQGGSEG---ASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESD 603
            .::..|.      .:..||.   :|:..|||..|:.     ..||:.......:|...:..:|:
  Fly   496 ELSGFTE------AKNDSEHHNISSTPTNNVLLAST-----FDATITPIKSEANDTSGQTLYET- 548

  Fly   604 RRVGFQVEGEDDDF------------YKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALAS 656
                 ..|||:.::            .:|||..|                     .|:|....:|
  Fly   549 -----CTEGEETNYESFGNNTTELSTEERPPDRH---------------------EELLRLYASS 587

  Fly   657 QERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG 721
            ....|..|        .|..|.:|:..:...:|:     |.:.....||:....|..|
  Fly   588 SNAQDEDP--------VSDAESDEETYIVYHEQK-----PSEVLFLTISSNFIREKDT------- 632

  Fly   722 VTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKV 786
            :||....::.:.|..:...:..:.......|..|...:.|:....|.....:   .|:.| ::..
  Fly   633 LTERTKAKWSLKILESCERVRSNTLRINFDTMRKDKQERIYCVENTLCQELE---KKLRD-ILSQ 693

  Fly   787 NGIVVVDADHYQAVQVL------------KA-------CGAVLVLVVQREVTRLIGHPVFSEDGS 832
            ..:..::...|:.|..|            ||       |.:|.|    .|||.|        ..|
  Fly   694 RDLTEMNISIYRCVNCLTQFTIEQKSKRYKAKELRCPDCRSVYV----AEVTEL--------SSS 746

  Fly   833 VSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAP--THSYSGNVFA 895
            :|:             |:..::.|..: :|..||         ::.|::::|.  ....|.::.|
  Fly   747 LSK-------------PSGEVAAEPKL-SPAMIV---------EESPVEELAAAINKEESNSIVA 788

  Fly   896 ---------TPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGS 951
                     ||......|...|:|.:   |||
  Fly   789 NCRLTTAKITPKLRSLTQATKSSANS---LNG--------------------------------- 817

  Fly   952 PPFKDDCDGIFISRITEGGLAYRDGKIMVG----DRVMAINGNDMTEAHHDAAVACLTEPQRFVR 1012
               ...|     |:||....::...:.:||    ||.|....|       ::.|..::.|.:...
  Fly   818 ---SSSC-----SKITNSQSSFDSNQSVVGSSNTDRDMEFRAN-------ESDVDIISNPSQSSI 867

  Fly  1013 LVLQREYRGPLEPPTS--------PRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLAT 1069
            .||...|.......||        |....:.:.::.|.....|  .|.:.:.|..||...:|.|.
  Fly   868 EVLDPNYVQSASRKTSEERRISQLPHLETIHDEVAKSKSFIER--EFGQLLAEQAQPTTPSTAAP 930

  Fly  1070 TTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGST 1134
            ..|. |..||:.:     .|..|.::|..|.:..|  :...|...||:...:..:.:   .:.|.
  Fly   931 LAPA-KSAVPSHV-----PLTESSSSGSVTDSICT--TYEQQATDAPQNLQNSLLTE---SSNSQ 984

  Fly  1135 TSGDSGE-------AQPSSLRPLTS 1152
            .||...|       |:.:||.|..|
  Fly   985 VSGSDAESNSRLKSAEDASLLPFAS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	59/290 (20%)
		leucine-rich repeat	18..38	CDD:275380	2/8 (25%)
		LRR_8	37..95	CDD:290566	14/72 (19%)
		leucine-rich repeat	39..61	CDD:275380	6/32 (19%)
		leucine-rich repeat	62..84	CDD:275380	8/25 (32%)
		LRR_8	84..138	CDD:290566	12/63 (19%)
		leucine-rich repeat	85..107	CDD:275380	3/24 (13%)
		leucine-rich repeat	108..130	CDD:275380	7/28 (25%)
		LRR_8	129..187	CDD:290566	13/62 (21%)
		leucine-rich repeat	131..153	CDD:275380	3/21 (14%)
		leucine-rich repeat	154..176	CDD:275380	4/21 (19%)
		leucine-rich repeat	177..199	CDD:275380	5/26 (19%)
		LRR_8	198..256	CDD:290566	15/64 (23%)
		leucine-rich repeat	200..222	CDD:275380	4/28 (14%)
		leucine-rich repeat	223..245	CDD:275380	6/21 (29%)
		LRR_8	267..325	CDD:290566	11/57 (19%)
		leucine-rich repeat	269..289	CDD:275380	1/19 (5%)
		leucine-rich repeat	292..314	CDD:275380	5/21 (24%)
		leucine-rich repeat	315..337	CDD:275380	8/21 (38%)
		LRR_4	337..375	CDD:289563	8/37 (22%)
		leucine-rich repeat	361..382	CDD:275380	7/20 (35%)
		PDZ	728..816	CDD:214570	15/106 (14%)
		PDZ_signaling	931..1016	CDD:238492	13/88 (15%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
CG9044	NP_001260114.1	LIP1	6..96	CDD:292526	19/99 (19%)
		LRR_RI	<102..302	CDD:238064	60/280 (21%)
		leucine-rich repeat	168..190	CDD:275380	3/21 (14%)
		LRR_4	189..229	CDD:289563	14/55 (25%)
		LRR_8	190..245	CDD:290566	18/77 (23%)
		leucine-rich repeat	191..212	CDD:275380	6/21 (29%)
		leucine-rich repeat	213..236	CDD:275380	10/44 (23%)
		leucine-rich repeat	237..258	CDD:275380	5/21 (24%)
		leucine-rich repeat	259..283	CDD:275380	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910