DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and lrrc40

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_956156.2	Gene:	lrrc40 / 334130	ZFINID:	ZDB-GENE-030131-6062	Length:	601	Species:	Danio rerio

Alignment Length:	592	Identity:	143/592 - (24%)
Similarity:	239/592 - (40%)	Gaps:	152/592 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLH----------------------- 60
            :|..|   .||..:|:.:|...:|.|....:.::|.:.:||:
Zfish    19 EKEDC---PVPYGLLKAARKSGQLNLSGRGLTEVPASVWRLNLDTPQEAKQNVSFGAEDRWWEQT 80

  Fly    61 RLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGF 125
            .|.||.||.|::..:|.|::....||.||:..|.:..:||.|..|:.||....|.|.:.:||||.
Zfish    81 DLTKLLLSSNKLQSIPDDVKLLPALVVLDIHDNQLSSLPDSIGDLEQLQKLILSHNKLTELPSGV 145

  Fly   126 SQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDL 190
            .:|.||..|.|....:..:|.|.|.|..|:.|:|..|.|..:||:::.|..|.:|||..|:::.|
Zfish   146 WRLTNLRCLHLQQNLIEQIPRDLGQLVNLDDLDLSNNHLIDIPESLANLQNLVKLDLSCNKLKSL 210

  Fly   191 PPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNL 255
            ||.:..:..|..|....||::.:||.|..:..|..|.:..|:|..|| |:....:|.:|....|.
Zfish   211 PPAISQMKNLRMLDCSRNQMESIPPVLAQMESLEQLYLRHNKLRYLP-ELPCCKTLKELHCGNNQ 274

  Fly   256 LEAL-PDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLN 319
            :|.| .:.:..|:.|::|:|..|:::.|.:.:...:.::.|.||.|.:|.||..:|.:.||.:|:
Zfish   275 IEVLEAEHLKHLNALSLLELRDNKVKSLPEEITLLQGLERLDLTNNDISSLPCGLGTLPKLKSLS 339

  Fly   320 VDRN----------------ALEYLPLEIGQCANLG----------------------------- 339
            ::.|                .|:||...:.:..|.|
Zfish   340 LEGNPLRAIRRDLLTKGTGELLKYLRSRVQEPPNGGLKEEPKTAMTFQSQAKINIHAIKTLKTLD 404

  Fly   340 --------------------------------------VLSLRD---------NKLKKLPPELGN 357
                                                  ::.|:|         |||..:|.:..:
Zfish   405 YSEKQDASIPDDVLDAVDGNPVANVNFSKNQLTAVPHRIVDLKDTLADINLGFNKLTTIPADFCH 469

  Fly   358 CTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSEN--QSQPLLTFQ-P--DTDAETGEQV----- 411
            ...|..:|:..|.|:.||..|..| :|::|.||.|  :|.|.:.:: |  :|...:..||
Zfish   470 LKQLMHIDLRNNLLISLPMELEGLIKLRSVILSFNRFKSFPEVLYRIPSLETILISSNQVGGIDA 534

  Fly   412 --------LSCYLLPQQEYQPITP-------ARDLESDSEPFEEREPSRTVVKFSEEATQEKETP 461
                    ||...|...:...:.|       .|.|..|..||  |.|...::....:|..|
Zfish   535 VQMKTLSRLSTLDLSNNDIMQVPPELGNCTSLRALMLDGNPF--RNPRAAILIKGTDAVLE---- 593

  Fly   462 FVRQNTP 468
            ::|...|
Zfish   594 YLRSRIP 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	85/287 (30%)
		leucine-rich repeat	18..38	CDD:275380	5/18 (28%)
		LRR_8	37..95	CDD:290566	19/80 (24%)
		leucine-rich repeat	39..61	CDD:275380	5/44 (11%)
		leucine-rich repeat	62..84	CDD:275380	8/21 (38%)
		LRR_8	84..138	CDD:290566	22/53 (42%)
		leucine-rich repeat	85..107	CDD:275380	9/21 (43%)
		leucine-rich repeat	108..130	CDD:275380	9/21 (43%)
		LRR_8	129..187	CDD:290566	21/57 (37%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	8/21 (38%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	17/57 (30%)
		leucine-rich repeat	200..222	CDD:275380	7/21 (33%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	17/73 (23%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	6/37 (16%)
		LRR_4	337..375	CDD:289563	12/113 (11%)
		leucine-rich repeat	361..382	CDD:275380	8/21 (38%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc40	NP_956156.2	LRR 1	33..56		4/22 (18%)
		LRR 2	79..101		8/21 (38%)
		LRR_8	82..138	CDD:290566	21/55 (38%)
		leucine-rich repeat	82..104	CDD:275380	8/21 (38%)
		LRR_RI	99..343	CDD:238064	78/244 (32%)
		LRR 3	102..124		8/21 (38%)
		leucine-rich repeat	105..127	CDD:275380	9/21 (43%)
		LRR 4	125..148		9/22 (41%)
		LRR_8	127..184	CDD:290566	21/56 (38%)
		leucine-rich repeat	128..150	CDD:275380	9/21 (43%)
		LRR 5	150..170		6/19 (32%)
		leucine-rich repeat	151..173	CDD:275380	7/21 (33%)
		LRR 6	171..193		8/21 (38%)
		leucine-rich repeat	174..196	CDD:275380	8/21 (38%)
		LRR 7	194..217		9/22 (41%)
		LRR_8	196..253	CDD:290566	18/56 (32%)
		leucine-rich repeat	197..219	CDD:275380	8/21 (38%)
		LRR 8	219..239		7/19 (37%)
		leucine-rich repeat	220..242	CDD:275380	7/21 (33%)
		LRR 9	240..264		7/24 (29%)
		leucine-rich repeat	243..288	CDD:275380	13/45 (29%)
		LRR_8	263..322	CDD:290566	15/58 (26%)
		LRR 10	266..285		4/18 (22%)
		LRR 11	286..308		6/21 (29%)
		leucine-rich repeat	289..311	CDD:275380	5/21 (24%)
		LRR 12	309..334		8/24 (33%)
		leucine-rich repeat	335..354	CDD:275380	3/18 (17%)
		LRR 13	336..355		2/18 (11%)
		LRR 14	397..420		0/22 (0%)
		leucine-rich repeat	400..449	CDD:275380	1/48 (2%)
		LRR 15	423..446		0/22 (0%)
		LRR 16	447..469		5/21 (24%)
		LRR_8	449..506	CDD:290566	17/56 (30%)
		leucine-rich repeat	450..472	CDD:275380	4/21 (19%)
		LRR 17	470..492		7/21 (33%)
		leucine-rich repeat	473..495	CDD:275380	8/21 (38%)
		LRR 18	493..516		8/22 (36%)
		leucine-rich repeat	496..518	CDD:275380	7/21 (33%)
		LRR_8	517..576	CDD:290566	11/58 (19%)
		LRR 19	518..539		3/20 (15%)
		leucine-rich repeat	519..542	CDD:275380	3/22 (14%)
		LRR 20	540..563		4/22 (18%)
		leucine-rich repeat	543..565	CDD:275380	4/21 (19%)
		LRR 21	565..586		7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910