DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP009630

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_553424.2	Gene:	AgaP_AGAP009630 / 3292016	VectorBaseID:	AGAP009630	Length:	410	Species:	Anopheles gambiae

Alignment Length:	307	Identity:	70/307 - (22%)
Similarity:	108/307 - (35%)	Gaps:	89/307 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 PTTTTVAPTGVQGGS---EGASSTANNVKAATAAVVAELAATVGGSDEVQDDD-------EQEDE 599
            |..||  |..:.||.   |..|.||.....|......|....|....|..:.|       |::|:
Mosquito     7 PGRTT--PETMVGGIRKWEQLSRTAGKQSLAPFGDGYETPRQVKSRKEDSESDQEPTEPPEEDDQ 69

  Fly   600 F------ESDRRVGFQVEGEDDD--------------------FYKRPPKLHRRDTPHHLKNKRV 638
            :      ||:    |..|.|:||                    ..:.|||  |.:...||.:  :
Mosquito    70 YTEQHYSESE----FHTEQEEDDDEQADRNEHGWSEHAHPPIQVSQYPPK--RFEQGSHLLH--I 126

  Fly   639 QHLTDKQASEILANALASQER-------NDTTPQHSLSGKVTS-----PIEEEEQLEVEQEQQ-- 689
            ..:||:.....|.::..|:.|       :..|.:.|.||:..|     ....|...|:|:..|
Mosquito   127 DFITDELGRFELPSSGQSRGRRPMGMVGSGATGRKSASGQQQSQQHNISFSRERVREIERTNQIL 191

  Fly   690 -----------QQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGL 743
                       |.|      :|..|:.  :|:..:..|.........:::      |:.||...|
Mosquito   192 LRRIITTRPTLQTQ------TSSKPVK--RTSSTNASPATSAATNRRKMQ------EKIAAENEL 242

  Fly   744 SIAGGK----GSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKV 786
            .|..|:    |.|....::..|.|..|....||.||||:.||:|:.:
Mosquito   243 LIRKGEDGKIGITVRYIEEGKILICAVLRRSPAYLAGLRYGDEVLSL 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	20/63 (32%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP009630	XP_553424.2	KIAA1430	<173..246	CDD:290590	15/86 (17%)
		PDZ	250..319	CDD:238080	14/40 (35%)
		PDZ	335..399	CDD:238080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910