DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP008172

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_555292.3	Gene:	AgaP_AGAP008172 / 3291666	VectorBaseID:	AGAP008172	Length:	630	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	125/551 - (22%)
Similarity:	209/551 - (37%)	Gaps:	158/551 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FKGCN--RQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDN 70
            |.|..  |.::..:.|..||    |..||.| :|.:|.|..|...:|....:.|..|..|.:::|
Mosquito    48 FNGMKLLRTLDLSNNRLHSL----EGQLRLS-SLTDLKLSHNRFTELSCCGWNLSSLTNLNINNN 107

  Fly    71 EIGRLPP------DIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPK-------LP 122
            .:.|||.      .|.::.|||...:|.:|  ::.|.:..|:.|.:.|.|.|.:..       |.
Mosquito   108 TLQRLPTCMEDALPIVSYLNLVSNVLSNDD--NVWDRLASLRQLTLLDLSYNRLTSMVWDNVTLS 170

  Fly   123 SGFSQLKN---------LTVLGLN-DMSLTT---------------------------------- 143
            :.:..|:|         :.:.|.| ||..||
Mosquito   171 TRYIDLRNNPMKYLNIPMAIDGFNVDMGCTTIDQLEVSSRSFNDTLSEIYCIPIRCSWHACGMVV 235

  Fly   144 ---LPADFGSLT------QLESLELRENL--------LKHLPETISQLTKLKRLDLGDNE----- 186
               |..:..|.|      .:|.|.:..|:        |::|..|......|.|:.|.::|
Mosquito   236 AVMLECEHISCTISNWAPGVEGLSVLSNIPNNVKYIRLRYLNITTLYSDLLDRVKLSNDETFQAT 300

  Fly   187 IEDLPPYLGYLPG----LHELWLDHN--QLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVS 245
            |:..|....||..    .:.|.:|.|  .::..|..|    ||..|.:.::||..:|:.|..||.
Mosquito   301 IQHSPIQHAYLSSRTNISNMLLMDTNLSDIEIEPHNL----KLEILSIMQSRLRRVPDSIKRLVV 361

  Fly   246 LTDLDLAQNLLEALPDGI-AKLSRLTILKLDQNRLQRLNDTLGN---CENMQELILTENFLSELP 306
            |...|:.|:|::.:...: .||..|.:|.|.||::..||.:..:   ..::|.:.|..|.|:.:.
Mosquito   362 LQAFDIVQSLVDYVDLSLFCKLQHLQVLNLMQNKISFLNYSRSSGVEFPSLQVIYLAHNLLTTIS 426

  Fly   307 AS-IGQMTKLNNLNVDRNALEYLP------------------LEIGQC----ANLGVLSLRDNKL 348
            .: ...|..||.|::..|:|..|.                  .|:..|    ::|.:|::.:|.|
Mosquito   427 MNDFNGMKLLNILDLSNNSLYSLEGQLRLSSLTELKLSHNRFTELSWCGWNLSSLTILNINNNTL 491

  Fly   349 KKLP---------------------------PELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAV 386
            ::||                           ..|.|...|.|||:|.|:|..:.::.|.|..:.:
Mosquito   492 QRLPTCMEDALPIVSYLSLVSNVLSNDDKIWDRLTNFNQLIVLDLSNNRLTSMVWNNVTLSTRYI 556

  Fly   387 WLSENQ------SQPLLTFQPDTDAETGEQV 411
            .|..|.      :.|...|:.||.....||:
Mosquito   557 NLRNNPIKYLNITTPKDMFKVDTGCSKIEQL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	83/355 (23%)
		leucine-rich repeat	18..38	CDD:275380	7/19 (37%)
		LRR_8	37..95	CDD:290566	17/63 (27%)
		leucine-rich repeat	39..61	CDD:275380	6/21 (29%)
		leucine-rich repeat	62..84	CDD:275380	7/27 (26%)
		LRR_8	84..138	CDD:290566	16/70 (23%)
		leucine-rich repeat	85..107	CDD:275380	6/21 (29%)
		leucine-rich repeat	108..130	CDD:275380	6/28 (21%)
		LRR_8	129..187	CDD:290566	20/123 (16%)
		leucine-rich repeat	131..153	CDD:275380	9/65 (14%)
		leucine-rich repeat	154..176	CDD:275380	6/29 (21%)
		leucine-rich repeat	177..199	CDD:275380	8/26 (31%)
		LRR_8	198..256	CDD:290566	17/63 (27%)
		leucine-rich repeat	200..222	CDD:275380	5/23 (22%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	16/61 (26%)
		leucine-rich repeat	269..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	292..314	CDD:275380	5/22 (23%)
		leucine-rich repeat	315..337	CDD:275380	8/43 (19%)
		LRR_4	337..375	CDD:289563	15/64 (23%)
		leucine-rich repeat	361..382	CDD:275380	8/20 (40%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP008172	XP_555292.3	leucine-rich repeat	4..29	CDD:275380
		LRR_8	28..86	CDD:290566	14/42 (33%)
		leucine-rich repeat	30..53	CDD:275380	2/4 (50%)
		LRR_4	54..90	CDD:289563	12/40 (30%)
		leucine-rich repeat	54..75	CDD:275380	8/25 (32%)
		leucine-rich repeat	76..122	CDD:275380	12/45 (27%)
		leucine-rich repeat	123..148	CDD:275380	7/26 (27%)
		leucine-rich repeat	149..170	CDD:275380	4/20 (20%)
		leucine-rich repeat	339..361	CDD:275380	7/21 (33%)
		leucine-rich repeat	386..411	CDD:275378	7/24 (29%)
		LRR_RI	<410..542	CDD:238064	27/131 (21%)
		LRR_8	410..468	CDD:290566	11/57 (19%)
		leucine-rich repeat	412..435	CDD:275380	5/22 (23%)
		leucine-rich repeat	436..457	CDD:275380	6/20 (30%)
		LRR_8	456..515	CDD:290566	8/58 (14%)
		leucine-rich repeat	458..480	CDD:275380	2/21 (10%)
		leucine-rich repeat	481..504	CDD:275380	6/22 (27%)
		leucine-rich repeat	505..530	CDD:275380	2/24 (8%)
		leucine-rich repeat	531..553	CDD:275380	9/21 (43%)
		leucine-rich repeat	554..574	CDD:275380	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910