DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP005667

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_556316.2	Gene:	AgaP_AGAP005667 / 3290019	VectorBaseID:	AGAP005667	Length:	414	Species:	Anopheles gambiae

Alignment Length:	363	Identity:	84/363 - (23%)
Similarity:	136/363 - (37%)	Gaps:	107/363 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRL------HRLRKLGLSDN 70
            |..:|.:|  |..|..||.       |::|:.:         .|.|.|      ..::.:.::..
Mosquito    51 NTVMEHID--HAILEGVPS-------TIQEVIV---------TNSFALRWISVPRAVKSMMITST 97

  Fly    71 EIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLG 135
            .:.|:  ||:...:|..|.||..|:..:||.|||.::|               |:..:.:..:.|
Mosquito    98 NLRRM--DIETNSSLSYLAVSVCDLVKVPDSIKHARAL---------------GWLYITSCKLQG 145

  Fly   136 LNDMSL--------------------TTLPADFGSLTQLESLELRENLLKHLP-ETISQLTKLKR 179
            ||..||                    .|.....|....|.|:.|.||||..:. |..:.|.::..
Mosquito   146 LNMASLCDNVRLGVLSLMRNKIRYVVNTSTRHCGVYDALASVTLSENLLTTVSMELFNVLVRMDG 210

  Fly   180 LDLGDNEIEDLPPYL---------------------GY-LPGLHELWLDHNQLQRLPPELGLLTK 222
            |.|.:|.|..|...|                     |: :|.|..|.||.|.|..:|..:...|.
Mosquito   211 LYLQNNRIRTLAGQLIHGALAELRMDGNKLSSVDLCGWTVPSLASLMLDRNNLTAVPLCVNNFTN 275

  Fly   223 LTYLDVSENRLEELPNE-ISGLVSLTDLDLAQNLLEALPDGIAKL-SRLTILKLDQNRLQRLN-- 283
            .:.|.:..|||.....| ::|:.||..|||:.|.|:.:....|.. :.|.:|.:|.|.|:.|:
Mosquito   276 TSLLTMRSNRLSNFTIESVAGMSSLRKLDLSCNTLKTVMLSTAHFPADLEMLNIDYNNLETLDLS 340

  Fly   284 -------------------DTLGNCENMQELILTENFL 302
                               |..|...|:.:|::.:|.:
Mosquito   341 FVPVRSLEVHVSYNLISSFDACGASRNVSQLLMYDNLI 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	77/320 (24%)
		leucine-rich repeat	18..38	CDD:275380	5/19 (26%)
		LRR_8	37..95	CDD:290566	12/63 (19%)
		leucine-rich repeat	39..61	CDD:275380	4/27 (15%)
		leucine-rich repeat	62..84	CDD:275380	3/21 (14%)
		LRR_8	84..138	CDD:290566	14/53 (26%)
		leucine-rich repeat	85..107	CDD:275380	10/21 (48%)
		leucine-rich repeat	108..130	CDD:275380	2/21 (10%)
		LRR_8	129..187	CDD:290566	19/78 (24%)
		leucine-rich repeat	131..153	CDD:275380	7/41 (17%)
		leucine-rich repeat	154..176	CDD:275380	9/22 (41%)
		leucine-rich repeat	177..199	CDD:275380	7/43 (16%)
		LRR_8	198..256	CDD:290566	21/58 (36%)
		leucine-rich repeat	200..222	CDD:275380	7/21 (33%)
		leucine-rich repeat	223..245	CDD:275380	6/22 (27%)
		LRR_8	267..325	CDD:290566	11/57 (19%)
		leucine-rich repeat	269..289	CDD:275380	8/40 (20%)
		leucine-rich repeat	292..314	CDD:275380	2/11 (18%)
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP005667	XP_556316.2	LRR_RI	<87..312	CDD:238064	60/241 (25%)
		leucine-rich repeat	110..132	CDD:275380	10/21 (48%)
		leucine-rich repeat	133..156	CDD:275380	7/37 (19%)
		leucine-rich repeat	157..178	CDD:275380	1/20 (5%)
		LRR_8	184..240	CDD:290566	15/55 (27%)
		leucine-rich repeat	184..207	CDD:275380	9/22 (41%)
		leucine-rich repeat	208..229	CDD:275380	6/20 (30%)
		leucine-rich repeat	230..252	CDD:275380	1/21 (5%)
		leucine-rich repeat	253..277	CDD:275380	8/23 (35%)
		leucine-rich repeat	278..299	CDD:275380	6/20 (30%)
		LRR_8	279..334	CDD:290566	18/54 (33%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..346	CDD:275380	6/21 (29%)
		leucine-rich repeat	347..367	CDD:275380	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910