DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and dlg1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	1166	Identity:	238/1166 - (20%)
Similarity:	383/1166 - (32%)	Gaps:	432/1166 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEAT 455
            :..:|.....|..|.|..|:. .| ||||::.|       :..|    :::.|...:|:.|.||.
  Fly    29 DDDEPAEDSSPADDEEEPEEE-EC-LLPQKKAQ-------IRCD----QDQPPLVVLVQPSAEAI 80

  Fly   456 QEKETPFVRQ--NTPHPKDLKAKAQKLKVERSRN--EEHANLVTLPEENGTKLAETPTETRTIAN 516
            :      |||  :..:|..:.|||..:..:....  |.....||.|:....|   .||..|
  Fly    81 E------VRQEIDDTNPVAVAAKASDMDGDSQLEVMEHQMETVTEPDPEPPK---CPTSLR---- 132

  Fly   517 NHQQQPHPVQQPIVGVNSKQPVV-VGVVTPTTTTVAPTGVQGGS-------------EGASSTAN 567
                  ..|::.:....|.|.:: .|.:..:|:.|....|:.|.             ||.||:::
  Fly   133 ------DSVRESVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYFEKSESDASRDEWEGPSSSSS 191

  Fly   568 NVKAATAAVVAELAA-TVGGS-------------------------------------------- 587
            .  ||...:::.::. :|..|
  Fly   192 G--AARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKP 254

  Fly   588 -----DEVQD-DDEQEDEFESDR--------RVGFQVEGEDDDFYKRPPKLHR------------ 626
                 ..||| ..|...|..|:|        :.|..:..::::......|.||
  Fly   255 KPKQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARL 319

  Fly   627 ---RDTPHHLKNKRV---------QHLTDKQ---ASEILANALASQERNDTTPQHSLSG------ 670
               :|....:..:||         |.|.|.|   ...:|.::.:.|::...|.|.:...
  Fly   320 SEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQA 384

  Fly   671 ---------KVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAG----KTAEASTDPDNLDGV 722
                     ::.|..|..::..|||:|:|||.|.  .||.||....    :.:::.:....::|.
  Fly   385 VKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQ--RSSRSPQQQNPQQQQGSKSRSGSQTVNGD 447

  Fly   723 TELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAG-LKVGDKVIKV 786
            .....|  :|.:||..:|||.|||||. ..|..|.|..|:|:::...|.|...| |.:.|.::.|
  Fly   448 DSWLYE--DIQLERGNSGLGFSIAGGT-DNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSV 509

  Fly   787 NGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAA 851
            |.:.|||..|..||..||..|.|:.|.|:|            :.|:.:
  Fly   510 NDVSVVDVPHASAVDALKKAGNVVKLHVKR------------KRGTAT----------------- 545

  Fly   852 SISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLL 916
                                                        ||.|......|..:|.:|..:
  Fly   546 --------------------------------------------TPAAGSAAGDARDSAASGPKV 566

  Fly   917 NGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVG 981
                       :...|::.  |:|||||||||.|:.....| :||:::::.:||.|..||::.:|
  Fly   567 -----------IEIDLVKG--GKGLGFSIAGGIGNQHIPGD-NGIYVTKLMDGGAAQVDGRLSIG 617

  Fly   982 DRVMAI--NGND--MTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSG 1042
            |:::|:  ||::  :....|:.|||
  Fly   618 DKLIAVRTNGSEKNLENVTHELAVA---------------------------------------- 642

  Fly  1043 YLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDS 1107
                                   ||.:.|             :..||...||....|:|:..
  Fly   643 -----------------------TLKSIT-------------DKVTLIIGKTQHLTTSASGG--- 668

  Fly  1108 STGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQV 1172
                                  |.|..:||.......|.|  .||.              ||.||
  Fly   669 ----------------------GGGGLSSGQQLSQSQSQL--ATSQ--------------SQSQV 695

  Fly  1173 HV---------ARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITD 1228
            |.         ::..|.|....:.||....|     |..|..:.  ||.||:...|.|:.
  Fly   696 HQQQHATPMVNSQSTEPGSRYASTNVLAAVP-----PGTPRAVS--TEDITREPRTITIQ----- 748

  Fly  1229 NQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDR 1293
                           |....|||:|:||.|..         ||::|.|:.||.|....:|:.||:
  Fly   749 ---------------KGPQGLGFNIVGGEDGQ---------GIYVSFILAGGPADLGSELKRGDQ 789

  Fly  1294 ILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQ 1358
            :|.||..:::.|||::|...|...|..:.|..|:.|     :|....:|..:.|......|..|.
  Fly   790 LLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRP-----EEYNRFEARIQELKQQAALGAGGS 849

  Fly  1359 RGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNE 1419
            ...........::|..:......|.||....|           |...|.|.::|...:.:|
  Fly   850 GTLLRTTQKRSLYVRALFDYDPNRDDGLPSRG-----------LPFKHGDILHVTNASDDE 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	36/88 (41%)
		PDZ_signaling	931..1016	CDD:238492	29/88 (33%)
		PDZ	1239..1329	CDD:214570	29/89 (33%)
		PDZ_signaling	1336..1425	CDD:238492	15/84 (18%)
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	10/55 (18%)
		PDZ	454..540	CDD:214570	36/98 (37%)
		PDZ_signaling	566..655	CDD:238492	34/178 (19%)
		PDZ_signaling	742..820	CDD:238492	29/106 (27%)
		SH3_DLG-like	862..922	CDD:212795	10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010