DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and CG32687

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001259412.1	Gene:	CG32687 / 31980	FlyBaseID:	FBgn0052687	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	92/346 - (26%)
Similarity:	141/346 - (40%)	Gaps:	74/346 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 NLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYL 194
            :|.::.|.|...:...|...|...:|::.|..|.|..||..:.|...||.|||..|.|..||..:
  Fly    25 SLDLVTLEDHLASPQKALLKSSGDIETMLLNHNRLVGLPRLLLQFGNLKILDLSSNAITTLPDAV 89

  Fly   195 GYLPGLHELWLDHNQLQRLPPELGLLTK-----------------LTYLDVSENRLEELPNEISG 242
            ..|| |..|...:|.|........||||                 |..|::|.|:|...|.:::.
  Fly    90 CQLP-LVTLIAKNNLLTNASLPKSLLTKMANGNGNGNATGGTNSTLKELNLSGNQLTHFPEQVTE 153

  Fly   243 LVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPA 307
            |..|..|.|..|.:.::...|.|:..|.:|.|..|.:..:.:.:|:...:|.|:|.:|.:..||.
  Fly   154 LRHLKYLYLGGNKISSVSKDIWKMQSLHVLSLGGNLISEVPEAVGSLNQLQALVLCDNLIEILPT 218

  Fly   308 SIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKL--------KKLPPELGNCTVLHVL 364
            ||.::..|.:|.:.:|.|.:||.:|....||..||||||.|        ...||.|        |
  Fly   219 SIARLKNLKSLLLHKNRLRHLPKDIVALKNLTELSLRDNPLVVRFVQDMALKPPTL--------L 275

  Fly   365 DVSGNQLLYL-----PYSL--------------VNLQLKAVWLSENQSQ-------------PLL 397
            :::|..:...     ||.:              ||...|.|:. :|:.:             |||
  Fly   276 ELAGRMVKASGQRPGPYDIPRTLAEYLNSANCCVNPNCKGVFF-DNRVEHIKFVDFCGKYRVPLL 339

  Fly   398 TF-------QPDTDAETGEQV 411
            .:       :|:..|..|..|
  Fly   340 QYLCSSKCIEPEQPAARGSSV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	48/169 (28%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	2/7 (29%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	92/346 (27%)
		LRR_8	129..187	CDD:290566	18/56 (32%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	7/21 (33%)
		leucine-rich repeat	177..199	CDD:275380	10/21 (48%)
		LRR_8	198..256	CDD:290566	20/74 (27%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	16/57 (28%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	7/21 (33%)
		LRR_4	337..375	CDD:289563	14/50 (28%)
		leucine-rich repeat	361..382	CDD:275380	6/39 (15%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
CG32687	NP_001259412.1	leucine-rich repeat	72..92	CDD:275380	9/19 (47%)
		leucine-rich repeat	94..133	CDD:275380	8/38 (21%)
		LRR_8	132..190	CDD:290566	17/57 (30%)
		LRR_4	134..171	CDD:289563	11/36 (31%)
		leucine-rich repeat	134..156	CDD:275380	7/21 (33%)
		leucine-rich repeat	157..179	CDD:275380	6/21 (29%)
		leucine-rich repeat	180..202	CDD:275380	5/21 (24%)
		LRR_8	202..259	CDD:290566	23/56 (41%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910