DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrsam1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001101303.1	Gene:	Lrsam1 / 311866	RGDID:	1564403	Length:	727	Species:	Rattus norvegicus

Alignment Length:	828	Identity:	175/828 - (21%)
Similarity:	295/828 - (35%)	Gaps:	252/828 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LDVSENRLEELPNEISGLVSLTDLDL----AQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTL 286
            ||:|:..|.|:|........:....:    ..:|...||...:.||..||..||
  Rat    34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLD----------- 87

  Fly   287 GNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKL 351
                      |.:|.|:.||..|||:|.|..|||:||.|.:||..:|....|..|:::|||||:|
  Rat    88 ----------LHDNQLTALPDDIGQLTALQVLNVERNQLTHLPRSVGNLLQLQTLNVKDNKLKEL 142

  Fly   352 PPELGNCTVLHVLDVSGNQLLYLPYSLVN------LQLKAVWLSENQSQPLLTFQPDTDAETGEQ 410
            |..||....|..||:|.|::..||..|.:      |.|.|:         .:.:.|......|..
  Rat   143 PDTLGELRSLRTLDISENEIQRLPQMLAHVRTLETLSLDAL---------SMVYPPPEVCGAGTA 198

  Fly   411 VLSCYLLPQQ--EYQP----ITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPH 469
            .:..:|..:.  :|.|    :.|.  ||.|.....:..|.....:||.|     |..:..:.:.:
  Rat   199 AVQQFLCKESGLDYYPPSQYLLPV--LEQDGAENSQDSPDGPTRRFSRE-----EAEWQNRFSDY 256

  Fly   470 PKDLKAK-AQKLKVERSRN---EEHANLV------------TLPEENGTKLAETPTETRTIANNH 518
            .|..:.| .:||:.||..:   .|||.|:            |:.:|. |:|.:..:|.:...:..
  Rat   257 EKRKEQKMLEKLEFERRLDLGQREHAELLQQSHSHKDEILQTVKQEQ-TRLEQGLSERQRCLDAE 320

  Fly   519 QQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAAT 583
            :||   :|:.:                             .:...|.|:.::..
  Rat   321 RQQ---LQEQL-----------------------------KQSEQSIASRIQRL----------- 342

  Fly   584 VGGSDEVQDDDEQEDEFE-----SDRRVGFQ----VEGEDDDFYKRPPKLHRRD--------TPH 631
                  :||:..|:...|     .:.|:..:    :..|:.:      .|.:|:        ...
  Rat   343 ------LQDNQRQKKSSEILKSLENERIRMEQLMSITQEETE------NLRQREIAAAMQQMLTE 395

  Fly   632 HLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLS------GKVTSPIEEE--------EQL 682
            ..|::.:|...:.|...::..|.:|....|...|..||      .|..|.|.:|        |.|
  Rat   396 SCKSRLIQMAYESQRQSLVQQACSSMAEMDKRFQQILSWQQMDQNKAISQILQESVMQKAAFEAL 460

  Fly   683 EVEQE---QQQQQQQHPFDSSLSPISAGKTAEASTDPDNL-DGVTELR------LEQY------- 730
            :|:::   :|.:.|....::.|..::..:....|.|.:.| :.|:|.|      |:|.
  Rat   461 QVKKDLTHRQIRSQIRLIETELLQLTQLELKRKSLDTETLQEMVSEQRWALSNLLQQLLKEKKQR 525

  Fly   731 --EIHIERTAAGLGLSIAGGKGSTPFKGDDDGIF-ISRVTEAGPADLAGLKVGDKVIKVNGIVVV 792
              |:|      |: |:....|..|  |.::..:. ..|:....|..|...:.|.:...|..:|.:
  Rat   526 EEELH------GI-LAELEAKSET--KQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLVEL 581

  Fly   793 DADHYQAVQVLKACGAVLVLVVQREVT-----RLIGHPVFSEDGSVSQISVETRPLVADAPPAAS 852
            .|:||            |.|.....:|     |:       ..|.::::.|.          .|.
  Rat   582 SAEHY------------LPLFAHHRITLDMLSRM-------GPGDLAKVGVS----------EAG 617

  Fly   853 ISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAV--SAAPNGL- 914
            :.||....|       :..|...:.||  ::.|..:....|...|||.|.:..:|  ||.|..|
  Rat   618 LQHEILRRA-------RDLLDVARVQP--ELKPPKNEVFGVSEPPTAPQELPESVRPSAPPAELD 673

  Fly   915 -------LLNGREAPLSYI-------------QLHT-TLIRDQIGQGL 941
                   :...|||.:.::             .|.| .|.|.:|.|.|
  Rat   674 VPTSECVVCLEREAQMVFLTCGHVCCCQQCCQPLRTCPLCRQEISQRL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	15/60 (25%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566	6/33 (18%)
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380	6/18 (33%)
		LRR_8	267..325	CDD:290566	20/57 (35%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	10/21 (48%)
		LRR_4	337..375	CDD:289563	16/37 (43%)
		leucine-rich repeat	361..382	CDD:275380	8/26 (31%)
		PDZ	728..816	CDD:214570	19/97 (20%)
		PDZ_signaling	931..1016	CDD:238492	5/11 (45%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrsam1	NP_001101303.1	leucine-rich repeat	33..54	CDD:275380	6/19 (32%)
		leucine-rich repeat	55..79	CDD:275380	3/23 (13%)
		LRR	<65..>181	CDD:227223	48/136 (35%)
		leucine-rich repeat	80..105	CDD:275380	12/45 (27%)
		leucine-rich repeat	106..128	CDD:275380	10/21 (48%)
		leucine-rich repeat	129..151	CDD:275380	11/21 (52%)
		leucine-rich repeat	152..174	CDD:275380	8/21 (38%)
		Smc	254..>559	CDD:224117	63/369 (17%)
		SAM_TAL	567..631	CDD:188922	16/99 (16%)
		RING-HC_LRSAM1	678..717	CDD:319429	7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910