DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Pard6a

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_006255552.1	Gene:	Pard6a / 307799	RGDID:	1303273	Length:	346	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	92/457 - (20%)
Similarity:	142/457 - (31%)	Gaps:	152/457 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1048 PANFSRSVVEVEQPY--KYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFA--TAAAATIDSS 1108
            ||....|:|||:..:  ::...|                    ||.:...||.  :.....:...
  Rat     8 PARSPDSIVEVKSKFDAEFRRFA--------------------LPRTSVRGFQEFSRLLCVVHQI 52

  Fly  1109 TGQPVPAPRRTNSVPMGDGDIGAGSTTS-GDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQV 1172
            .|.                |:..|.|.: ||        |.|||:||             |.|:.
  Rat    53 PGL----------------DVLLGYTDAHGD--------LLPLTNDD-------------SLHRA 80

  Fly  1173 HVARP-------------NEVGVSAVTVNVNKPQPDLPMFPAA------------PTELGRVTET 1212
            ..:.|             :..|::..:.::.:.:..|.:.|.|            |.:..:|:..
  Rat    81 LASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSV 145

  Fly  1213 ITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGS---LGFSIIGGTDHSCVPFG-TREPGIFI 1273
            |......||               ...|.|.|: ||   |||.|..|......|.| .|.|||||
  Rat   146 IDVDLLPET---------------HRRVRLHKH-GSDRPLGFYIRDGMSVRVAPQGLERVPGIFI 194

  Fly  1274 SHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVL 1338
            |.:|.||:|...|.|.:.|.||:||..:|:..|.......::.....:.:|::    |...:..:
  Rat   195 SRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK----PANQRNNV 255

  Fly  1339 LSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLG 1403
            :..|.|...|....|      ..|.||..:                          :.|...::.
  Rat   256 VRGASGRLTGPSSVG------PGPTDPDSD--------------------------DDNSDPVIE 288

  Fly  1404 ASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGS 1468
            ..|....|.|.      |..:|.......|:.|   ||......:|....:.|...|.|...:|.
  Rat   289 NRHPPCSNGLS------QGPLCWDLQPGCLLPS---AGSSLPSLDSREQANSGWGNGMRGDVSGF 344

  Fly  1469 EL 1470
            .|
  Rat   345 SL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	33/93 (35%)
		PDZ_signaling	1336..1425	CDD:238492	12/88 (14%)
Pard6a	XP_006255552.1	PB1_Par6	16..95	CDD:99724	23/135 (17%)
Pard6a	XP_006255552.1	PDZ_signaling	156..247	CDD:238492	33/91 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910