Protein Alignment scrib and Lrrc8b

DIOPT Version :10

• Sequence 1: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Sequence 2: NP_001100674.1
• Gene: Lrrc8b / 305135
• RGDID: 1563429
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 376
• Identity: 116/376 - (30%)
• Similarity: 174/376 - (46%)
• Gaps: 63/376 - (16%)

  Fly    16 EFVDKRHCSLPQVPEEILRYSRT----LEEL-FLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRL 75
            |..|....||..:||..|..:.:    |.|| ...::.:.|.|...|....|:.|.|...|:|::
  Rat   438 ELTDMEVLSLELIPEVKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKI 502

  Fly    76 PPDIQNFENLVELDVSRNDIPD-----IPD---DIKHLQSLQVADFSSNPIPK-----LPS---- 123
            |..:.:.:||.||.:|...:|:     .|:   |:|:|::|.:.. |.:.||:     |||
  Rat   503 PRWVFHLKNLKELYLSGCVLPEQLSSMQPEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKL 566

  Fly   124 -------------GFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS--Q 173
                         ...::.||..|.|....|..:|....||..|..|:|:||.||.:.|.||  .
  Rat   567 SLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIISFQH 631

  Fly   174 LTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPN 238
            |..|..|.|..|.|..:|..:|.|..|.:|:|.||.::.||.:|.|.|||.|||:|.|.|..:|.
  Rat   632 LPSLSCLKLWHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPE 696

  Fly   239 EISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLS 303
            ||..|.:|....:..|.:|.||||                       |..|:.:|.|:|..|.|:
  Rat   697 EIQYLTNLQYFAVTNNNIEMLPDG-----------------------LFQCKKLQCLLLGRNSLT 738

  Fly   304 ELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANL--GVLSLRDNKLKKLP 352
            :|...:|:::.|.:|.:..|.||.||:|:..|.:|  ..|.:.|:.|..||
  Rat   739 DLSPLVGELSNLTHLELIGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLP 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	leucine-rich repeat	18..38	CDD:275380	6/19 (32%)
		LRR_8	37..95	CDD:404697	17/62 (27%)
		leucine-rich repeat	39..61	CDD:275380	6/22 (27%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR	67..408	CDD:443914	101/320 (32%)
		leucine-rich repeat	85..107	CDD:275380	9/29 (31%)
		leucine-rich repeat	108..130	CDD:275380	7/43 (16%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	11/23 (48%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		leucine-rich repeat	200..222	CDD:275380	9/21 (43%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		leucine-rich repeat	269..289	CDD:275380	1/19 (5%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ1_Scribble-like	730..816	CDD:467188
		PDZ2_Scribble-like	927..1019	CDD:467187
		PDZ3_Scribble-like	1238..1327	CDD:467186
		PDZ4_Scribble-like	1331..1428	CDD:467185
Lrrc8b	NP_001100674.1	leucine-rich repeat	635..657	CDD:275380	8/21 (38%)
		leucine-rich repeat	658..680	CDD:275380	9/21 (43%)
		leucine-rich repeat	704..726	CDD:275380	9/44 (20%)
		leucine-rich repeat	727..750	CDD:275380	7/22 (32%)
		leucine-rich repeat	751..772	CDD:275380	8/20 (40%)
		Pannexin_like	1..334	CDD:463622
		PLN00113	<432..>672	CDD:215061	68/234 (29%)
		leucine-rich repeat	465..488	CDD:275380	6/22 (27%)
		leucine-rich repeat	489..511	CDD:275380	6/21 (29%)
		leucine-rich repeat	512..539	CDD:275380	7/26 (27%)
		leucine-rich repeat	540..562	CDD:275380	6/22 (27%)
		LRR	<560..>802	CDD:443914	83/253 (33%)
		leucine-rich repeat	563..586	CDD:275380	0/22 (0%)
		leucine-rich repeat	587..609	CDD:275380	7/21 (33%)
		leucine-rich repeat	610..634	CDD:275380	11/23 (48%)