DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrrc8d

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001008339.2	Gene:	Lrrc8d / 305131	RGDID:	1309601	Length:	860	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	103/353 - (29%)
Similarity:	162/353 - (45%)	Gaps:	58/353 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HC--SLPQVPEEILR-YSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFE 83
            ||  .:.|.....|| :.|.|...|.|   :.::|...:.|..||:|.|    ||.|     |.|
  Rat   524 HCPAKVEQTAFSFLRDHLRCLHVKFTD---VAEIPAWVYLLKNLRELYL----IGNL-----NSE 576

  Fly    84 N--LVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFS-------------------- 126
            |  ::.|:..|        :::||:.|.|   .|| :.|:||..:
  Rat   577 NNKMIGLESLR--------ELRHLKILHV---KSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV 629

  Fly   127 -----QLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS--QLTKLKRLDLGD 184
                 ::.|:..|.|.:..|..:|....||:.|:.|:|:.|.::.:.|.||  .|.:|..|.|..
  Rat   630 LNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWH 694

  Fly   185 NEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDL 249
            |:|..:||.:.::..|..|:..:|:|:.||..:..|.||..||||.|.:..:|.||..|.:|..|
  Rat   695 NKIVAIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHL 759

  Fly   250 DLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQ--M 312
            .:..|.::.||..:.|..:|..|.|.||.:..|.:.:.....:.:|.|..|.|..|||.:||  |
  Rat   760 HITGNKVDVLPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRM 824

  Fly   313 TKLNNLNVDRNALEYLPLEIGQCANLGV 340
            .|.:.|.|:....:.||||:.:..|..|
  Rat   825 LKKSGLVVEDQLFDTLPLEVKEALNQDV 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	83/292 (28%)
		leucine-rich repeat	18..38	CDD:275380	5/18 (28%)
		LRR_8	37..95	CDD:290566	18/59 (31%)
		leucine-rich repeat	39..61	CDD:275380	5/21 (24%)
		leucine-rich repeat	62..84	CDD:275380	8/21 (38%)
		LRR_8	84..138	CDD:290566	15/80 (19%)
		leucine-rich repeat	85..107	CDD:275380	4/21 (19%)
		leucine-rich repeat	108..130	CDD:275380	7/46 (15%)
		LRR_8	129..187	CDD:290566	19/59 (32%)
		leucine-rich repeat	131..153	CDD:275380	6/21 (29%)
		leucine-rich repeat	154..176	CDD:275380	8/23 (35%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	21/57 (37%)
		leucine-rich repeat	200..222	CDD:275380	7/21 (33%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	19/59 (32%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	10/23 (43%)
		leucine-rich repeat	315..337	CDD:275380	6/21 (29%)
		LRR_4	337..375	CDD:289563	2/4 (50%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrrc8d	NP_001008339.2	Pannexin_like	3..386	CDD:289311
		leucine-rich repeat	517..538	CDD:275378	3/13 (23%)
		LRR_RI	557..834	CDD:238064	87/297 (29%)
		leucine-rich repeat	564..591	CDD:275380	12/43 (28%)
		leucine-rich repeat	592..617	CDD:275380	8/28 (29%)
		LRR_8	638..697	CDD:290566	19/58 (33%)
		leucine-rich repeat	639..661	CDD:275380	6/21 (29%)
		leucine-rich repeat	662..686	CDD:275380	8/23 (35%)
		LRR_8	685..743	CDD:290566	21/57 (37%)
		leucine-rich repeat	687..709	CDD:275380	7/21 (33%)
		leucine-rich repeat	710..732	CDD:275380	7/21 (33%)
		leucine-rich repeat	733..755	CDD:275380	10/21 (48%)
		LRR_8	755..810	CDD:290566	14/54 (26%)
		leucine-rich repeat	756..778	CDD:275380	6/21 (29%)
		leucine-rich repeat	779..801	CDD:275380	6/21 (29%)
		leucine-rich repeat	802..822	CDD:275380	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910