DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and PDZRN4

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001158067.1	Gene:	PDZRN4 / 29951	HGNCID:	30552	Length:	1036	Species:	Homo sapiens

Alignment Length:	779	Identity:	153/779 - (19%)
Similarity:	273/779 - (35%)	Gaps:	235/779 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1240 VVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSK 1304
            :||.:...:|||:||||..:.....||...||::|.|:..|.|.:...|.:.|:|::||..|:||
Human   225 IVLERENDTLGFNIIGGRPNQNNQEGTSTEGIYVSKILENGPADRADGLEIHDKIMEVNGKDLSK 289

  Fly  1305 ATHQDAV------------------------------LELLKPGDEIKLTIQH--------DPLP 1331
            |||::||                              ::|:....:..:|.:|        .|.|
Human   290 ATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTP 354

  Fly  1332 P-------------------------------------------GFQEVLLSKAEG-ERLGMHIK 1352
            |                                           .::||.|.:... |:||:.:.
Human   355 PVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVC 419

  Fly  1353 GGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRN-- 1415
            ...:       |..|.|::||:::....|.:|||::.|.|:|::||..:  .:.::||.:|.|
Human   420 YRTD-------DEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV--QNREEAVALLSNDE 475

  Fly  1416 --------AGNEIQLVVCKGY--DKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSEL 1470
                    |..||||  .:|:  |:.|..........:....|.:...:....:..:..|.....
Human   476 CKRIVLLVARPEIQL--DEGWLEDERNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGT 538

  Fly  1471 SQSQSVSSLDHEE-------DERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAA 1528
            :.:.:.||.:||:       ||.||.|..  :.|:..|:.|...|:.:....   |.|..|..:.
Human   539 TDTATSSSNNHEKDSGVGRTDESLRNDES--SEQENAAEDPNSTSLKSKRDL---GQSQDTLGSV 598

  Fly  1529 TSNIT-PLPTAAAVASADLTAPDTPATQTVALI--------HAE------------QQAHQQQQQ 1572
            ..... .|.:...:.|..:..||....:...|:        |.|            .|..|:..:
Human   599 ELQYNESLVSGEYIDSDCIGNPDEDCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVE 663

  Fly  1573 TQLAPLGQE-KSTQEKVLEIVRA----------ADAFTTVPPKSPSEHHEQDKIQKTTTVVISKH 1626
            .:|..|.:| ::.:.:...|::|          .|.:|.         |:.......|::.:.:.
Human   664 HELQLLNEELRNIELECQNIMQAHRLQKVTDQYGDIWTL---------HDGGFRNYNTSIDMQRG 719

  Fly  1627 TLDTNPTTPTTPAAPLSIA--GAESANSAGAPSPAVPASTPGSAPVLPAV----------AVQTQ 1679
            .||.....|.......|.|  .|||..|    :|.....:|.|:  ||.|          :....
Human   720 KLDDIMEHPEKSDKDSSSAYNTAESCRS----TPLTVDRSPDSS--LPRVINLTNKKNLRSTMAA 778

  Fly  1680 TQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKPTPTKVPKSVSD----------------- 1727
            ||::|.:..:|..|....|......||.:::.:.....|.: .|:||:
Human   779 TQSSSGQSSKESTSTKAKTTEQGCSAESKEKVLEGSKLPDQ-EKAVSEHIPYLSPYHSSSYRYAN 842

  Fly  1728 ---KKRFFESAME--DQHKPTQKTDKVFSFL---------SKDEVE---KLRQEEERKIATLRRD 1775
               ..|.::|.|:  .|....:......|.:         |:.::|   |:|.:..|.|.  :|.
Human   843 IPAHARHYQSYMQLIQQKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYIT--KRP 905

  Fly  1776 KNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVDNAALGHFDDAEDMR 1839
            ...|:|            ::|........||...||          |::....:|.:...|:.:
Human   906 VRDRIL------------KERALKIKEERSGMTTDD----------DTMSEMKMGRYWSKEERK 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	33/126 (26%)
		PDZ_signaling	1336..1425	CDD:238492	29/99 (29%)
PDZRN4	NP_001158067.1	RING	17..54	CDD:238093
		Sina	66..>108	CDD:302762
		PDZ	221..313	CDD:214570	30/87 (34%)
		PDZ_signaling	402..484	CDD:238492	24/90 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910