DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrrc8c

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001032256.1	Gene:	Lrrc8c / 289443	RGDID:	1306585	Length:	803	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	108/397 - (27%)
Similarity:	165/397 - (41%)	Gaps:	92/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VPEEILRYSRTLEELFLD--ANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVEL-- 88
            :|..|.:.. .|:||.|.  :..|.....:|.: ..|:.|.:..:::..|||.:....||.||
  Rat   459 IPATIAQLD-NLQELSLHQCSVKIHSAALSFLK-ENLKVLSVKFDDMRELPPWMYGLRNLEELYL 521

  Fly    89 ------DVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLP------------------------- 122
                  |:|:|   ...:.::.|:||::....|| :.|:|
  Rat   522 VGSLSHDISKN---VTLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVML 582

  Fly   123 SGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS--QLTKLKRLDLGDN 185
            :...::.|||.|.|....|..:|....||..|:.|:|:||.||.:.|.:|  .|.||..|.|..|
  Rat   583 NNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYN 647

  Fly   186 EIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLD 250
            .|..:|.::..|..|..|:..||:::.||..|.|..|:.|||:|.|.:..:|.||..|.||....
  Rat   648 SIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS 712

  Fly   251 LAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKL 315
            :..|.:|:|||                                ||...:              ||
  Rat   713 ITCNKVESLPD--------------------------------ELYFCK--------------KL 731

  Fly   316 NNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLY--LPYSL 378
            ..|.:.:|:|..|..:||....|..|.::.|..:.||||||:|..|....:.....|:  || |.
  Rat   732 KTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLP-SD 795

  Fly   379 VNLQLKA 385
            |..|:||
  Rat   796 VREQMKA 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	79/291 (27%)
		leucine-rich repeat	18..38	CDD:275380	2/9 (22%)
		LRR_8	37..95	CDD:290566	18/67 (27%)
		leucine-rich repeat	39..61	CDD:275380	6/23 (26%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR_8	84..138	CDD:290566	19/86 (22%)
		leucine-rich repeat	85..107	CDD:275380	7/29 (24%)
		leucine-rich repeat	108..130	CDD:275380	5/46 (11%)
		LRR_8	129..187	CDD:290566	24/59 (41%)
		leucine-rich repeat	131..153	CDD:275380	8/21 (38%)
		leucine-rich repeat	154..176	CDD:275380	10/23 (43%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	21/57 (37%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	9/21 (43%)
		LRR_8	267..325	CDD:290566	6/57 (11%)
		leucine-rich repeat	269..289	CDD:275380	0/19 (0%)
		leucine-rich repeat	292..314	CDD:275380	2/21 (10%)
		leucine-rich repeat	315..337	CDD:275380	7/21 (33%)
		LRR_4	337..375	CDD:289563	12/39 (31%)
		leucine-rich repeat	361..382	CDD:275380	6/22 (27%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrrc8c	NP_001032256.1	Pannexin_like	1..338	CDD:289311
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..211
		LRR 1. /evidence=ECO:0000255	397..420
		LRR 2. /evidence=ECO:0000255	421..443
		leucine-rich repeat	446..468	CDD:275380	2/9 (22%)
		LRR 3. /evidence=ECO:0000255	446..466		2/6 (33%)
		LRR 4. /evidence=ECO:0000255	467..488		5/21 (24%)
		leucine-rich repeat	469..492	CDD:275380	6/23 (26%)
		LRR 5. /evidence=ECO:0000255	490..513		5/23 (22%)
		leucine-rich repeat	493..515	CDD:275380	5/21 (24%)
		LRR 6. /evidence=ECO:0000255	515..537		7/24 (29%)
		leucine-rich repeat	516..543	CDD:275380	7/29 (24%)
		LRR 7. /evidence=ECO:0000255	541..563		7/22 (32%)
		leucine-rich repeat	544..566	CDD:275380	5/22 (23%)
		LRR 8. /evidence=ECO:0000255	565..587		0/21 (0%)
		leucine-rich repeat	567..590	CDD:275380	0/22 (0%)
		LRR 9. /evidence=ECO:0000255	588..611		7/22 (32%)
		LRR_8	589..649	CDD:290566	24/59 (41%)
		LRR_RI	<590..695	CDD:238064	41/104 (39%)
		leucine-rich repeat	591..613	CDD:275380	8/21 (38%)
		LRR 10. /evidence=ECO:0000255	613..635		9/21 (43%)
		leucine-rich repeat	614..638	CDD:275380	10/23 (43%)
		LRR_8	637..695	CDD:290566	22/57 (39%)
		LRR 11. /evidence=ECO:0000255	637..659		7/21 (33%)
		leucine-rich repeat	639..661	CDD:275380	7/21 (33%)
		LRR 12. /evidence=ECO:0000255	660..682		7/21 (33%)
		leucine-rich repeat	662..684	CDD:275380	8/21 (38%)
		LRR 13. /evidence=ECO:0000255	684..705		9/20 (45%)
		LRR 14. /evidence=ECO:0000255	706..728		9/53 (17%)
		LRR_8	707..764	CDD:290566	20/102 (20%)
		leucine-rich repeat	708..730	CDD:275380	8/67 (12%)
		LRR 15. /evidence=ECO:0000255	730..751		8/20 (40%)
		leucine-rich repeat	731..752	CDD:275380	7/20 (35%)
		LRR 16. /evidence=ECO:0000255	752..774		9/21 (43%)
		LRR 17. /evidence=ECO:0000255	776..799		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910