DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Drc3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001013879.1	Gene:	Drc3 / 287371	RGDID:	1309150	Length:	523	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	124/637 - (19%)
Similarity:	219/637 - (34%)	Gaps:	200/637 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQ 106
            |.||..:|..: .|.::...||||.|::|.|.|: ..::|..:||.||:|.|:|..|.
  Rat    48 LQLDFQNILRI-DNLWQFENLRKLQLNNNIIERI-EGLENLTHLVWLDLSFNNIEAIE------- 103

  Fly   107 SLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETI 171
                                        ||:            :|..||.|.|..|.:..: :::
  Rat   104 ----------------------------GLD------------TLVNLEDLSLSHNRISKI-DSL 127

  Fly   172 SQLTKLKRLDLGDNEIEDLPP--YLGYLPGLHELWLDHNQLQRLPPE----LGLLTKLTYLDVSE 230
            ..|..|:.|.||:|:|.::..  ||...|.|..|.|..|.:......    ...|..|.|||.
  Rat   128 DPLVNLQVLSLGNNQINNMMNIIYLRRFPCLRTLSLSGNPVSEAEEYKVFIYAYLPDLVYLDF-- 190

  Fly   231 NRLEELPNEISGL---VSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLND-TLGNCEN 291
            .|::|...|::.:   .|:.:|...:.|::..            |:.:|.:.|:|.: .:...|:
  Rat   191 RRVDEQAREVAKMKHQYSIDELKHREALMQIR------------LEEEQAKQQKLAEHKMAFVEH 243

  Fly   292 MQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQ------------CANLGVLSLR 344
            :....|.::..|:              :|:.|.|.||| .:|:            |.|:....|.
  Rat   244 LNGPFLFDSMYSD--------------DVEGNKLSYLP-GVGELLEAYKDKFVIICLNIFEYGLS 293

  Fly   345 DNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGE 409
            ..:.:|:..:..|..:...:..:.:|          .:||.....|.....|...:.::|..|.|
  Rat   294 QQEKRKIELDTFNECIQEAIQENQDQ----------GKLKIAKFEEKHLLNLNAIREESDLFTME 348

  Fly   410 QVLS-CYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKE---TPFVRQNTPHP 470
            |.|: |.                ||.:|.|      .|::....:..::.|   ..|.|..|
  Rat   349 QKLTECN----------------ESITELF------NTLMILEMQLVEQLEETINVFERNIT--- 388

  Fly   471 KDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSK 535
                                 :||.|..||...|.   .:.|.:.|:|.::...     :.:|:.
  Rat   389 ---------------------DLVGLFIENVQSLI---AQCRDLENHHHEKLLE-----IAINTL 424

  Fly   536 QPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAATVGGSDEVQ--DDDEQED 598
            :.::.|.:...    .|..|:.......:..|               .||.|.::.  ..|.:||
  Rat   425 EKILKGEMDED----LPDDVRALFVDKDTIVN---------------AVGASHDIHLLKIDNRED 470

  Fly   599 EFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKN-KRVQHLTDKQASEI 649
            |.         |.|.:........|:|:.:...:.|. |.:....|...||:
  Rat   471 EL---------VTGVNSWCAHLVDKIHKDEIMRNRKRVKEINQFVDHMQSEL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	58/249 (23%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	20/52 (38%)
		leucine-rich repeat	39..61	CDD:275380	5/18 (28%)
		leucine-rich repeat	62..84	CDD:275380	9/21 (43%)
		LRR_8	84..138	CDD:290566	10/53 (19%)
		leucine-rich repeat	85..107	CDD:275380	8/21 (38%)
		leucine-rich repeat	108..130	CDD:275380	0/21 (0%)
		LRR_8	129..187	CDD:290566	14/57 (25%)
		leucine-rich repeat	131..153	CDD:275380	3/21 (14%)
		leucine-rich repeat	154..176	CDD:275380	6/21 (29%)
		leucine-rich repeat	177..199	CDD:275380	8/23 (35%)
		LRR_8	198..256	CDD:290566	15/64 (23%)
		leucine-rich repeat	200..222	CDD:275380	5/25 (20%)
		leucine-rich repeat	223..245	CDD:275380	7/24 (29%)
		LRR_8	267..325	CDD:290566	9/58 (16%)
		leucine-rich repeat	269..289	CDD:275380	4/20 (20%)
		leucine-rich repeat	292..314	CDD:275380	2/21 (10%)
		leucine-rich repeat	315..337	CDD:275380	8/33 (24%)
		LRR_4	337..375	CDD:289563	5/37 (14%)
		leucine-rich repeat	361..382	CDD:275380	1/20 (5%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Drc3	NP_001013879.1	LRR 1	44..65		5/17 (29%)
		leucine-rich repeat	48..66	CDD:275378	5/18 (28%)
		LRR_4	65..105	CDD:289563	17/75 (23%)
		LRR_8	66..121	CDD:290566	25/102 (25%)
		LRR 2	66..87		9/21 (43%)
		leucine-rich repeat	67..88	CDD:275378	9/21 (43%)
		LRR_4	87..129	CDD:289563	16/89 (18%)
		LRR 3	88..109		10/67 (15%)
		leucine-rich repeat	89..110	CDD:275378	11/67 (16%)
		LRR 4	110..131		5/21 (24%)
		leucine-rich repeat	111..132	CDD:275378	6/21 (29%)
		LRR 5	132..153		7/20 (35%)
		leucine-rich repeat	158..169	CDD:275378	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910