DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and Cnot6

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001380807.1 Gene:Cnot6 / 287249 RGDID:1310783 Length:557 Species:Rattus norvegicus


Alignment Length:522 Identity:115/522 - (22%)
Similarity:188/522 - (36%) Gaps:158/522 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 PDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENL 163
            |.|.:.:.::..::.::|      ...|....|.:.|    .:.:|.:...|||.|.:|.|.:|.
  Rat     8 PPDPRRMYTIMSSEEAAN------GKKSHWAELEISG----KVRSLSSSLWSLTHLTALHLSDNS 62

  Fly   164 LKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDV 228
            |..:|..|::|..|..|||..|:|:.||..||.:..|.||.|::|||:.||.|||.|.:|..|.:
  Rat    63 LSCIPSDIAKLHNLVYLDLSHNQIQSLPAELGNMVSLRELHLNYNQLRVLPFELGKLFQLQTLSL 127

  Fly   229 SENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQ 293
            ..|.|.:              |:....||  |||..:|               ||..|.|.....
  Rat   128 KGNPLTQ--------------DILNLCLE--PDGTRRL---------------LNYLLDNLSGTA 161

  Fly   294 ELILTEN-------FLSE----LPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNK 347
            :.|.||.       .|.|    .|.::..:...|.| .|:.|...|   .|.|.:..:  ..|.:
  Rat   162 KRISTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVL-CDKYATRQL---YGYCPSWAL--NWDYR 220

  Fly   348 LKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVL 412
            .|.:..|:.:|..                .:::||                     :.|| ||..
  Rat   221 KKAIIQEILSCNA----------------DIISLQ---------------------EVET-EQYY 247

  Fly   413 SCYLLPQQE------YQPITPARDLESDSEPFEERE----------------PSRTVVKFSEEAT 455
            |.:|:..:|      :.|.:.||.:..     :||:                ..:..|:|::.|.
  Rat   248 SFFLVELKERGYNGFFSPKSRARTMSE-----QERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAM 307

  Fly   456 QEKETPFVRQNTPHPKD-----LKAKAQKLKVERSRNEEH------------ANLVTLPEENGTK 503
            ...|......|....||     :..:.:|..:|.|..:.|            |::...||.:..|
  Rat   308 ANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHWDPEYSDVK 372

  Fly   504 LAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVV----------GVVTPTTTTVAPTGVQGG 558
            |.:|......:.|...:....::..::|.....|:|:          |||...:|        ||
  Rat   373 LVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLST--------GG 429

  Fly   559 SE 560
            .|
  Rat   430 VE 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 52/183 (28%)
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380
LRR_8 84..138 CDD:290566 6/38 (16%)
leucine-rich repeat 85..107 CDD:275380 2/7 (29%)
leucine-rich repeat 108..130 CDD:275380 2/21 (10%)
LRR_8 129..187 CDD:290566 19/57 (33%)
leucine-rich repeat 131..153 CDD:275380 5/21 (24%)
leucine-rich repeat 154..176 CDD:275380 8/21 (38%)
leucine-rich repeat 177..199 CDD:275380 10/21 (48%)
LRR_8 198..256 CDD:290566 18/57 (32%)
leucine-rich repeat 200..222 CDD:275380 13/21 (62%)
leucine-rich repeat 223..245 CDD:275380 4/21 (19%)
LRR_8 267..325 CDD:290566 13/68 (19%)
leucine-rich repeat 269..289 CDD:275380 3/19 (16%)
leucine-rich repeat 292..314 CDD:275380 6/32 (19%)
leucine-rich repeat 315..337 CDD:275380 7/21 (33%)
LRR_4 337..375 CDD:289563 4/37 (11%)
leucine-rich repeat 361..382 CDD:275380 0/20 (0%)
PDZ 728..816 CDD:214570
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
Cnot6NP_001380807.1 LRR <52..>159 CDD:227223 46/137 (34%)
LRR 1 52..73 7/20 (35%)
leucine-rich repeat 53..75 CDD:275378 8/21 (38%)
LRR 2 75..96 10/20 (50%)
leucine-rich repeat 76..98 CDD:275378 10/21 (48%)
LRR 3 98..120 12/21 (57%)
leucine-rich repeat 99..121 CDD:275378 13/21 (62%)
LRR 4 121..143 7/37 (19%)
leucine-rich repeat 122..133 CDD:275378 3/10 (30%)
Nuclease domain. /evidence=ECO:0000250 153..557 61/336 (18%)
Deadenylase_CCR4a 191..540 CDD:197340 53/298 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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