DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and GP5

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_004479.1 Gene:GP5 / 2814 HGNCID:4443 Length:560 Species:Homo sapiens


Alignment Length:346 Identity:112/346 - (32%)
Similarity:168/346 - (48%) Gaps:31/346 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 LPQVPEEILRYSRTLEELFLDANHIRDLPKNFF-RLHRLRKLGLSDNEIGRLPPDI-QNFENLVE 87
            :..:|..:|.....||:||||.|.:|.:.:|.| :|..|::|.|:.|::..||..: .|.|||..
Human   110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKL 174

  Fly    88 LDVSRNDIPDIPDDIKHLQS-LQVADFSSNPIPKLPSG-FSQLKNLTVLGLNDMSLTTL-PADFG 149
            ||:|.|::..:|..:...|: |:.....||.:..|.|| .:.|..||.|..:...:.:: |..|.
Human   175 LDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFD 239

  Fly   150 SLTQLESLELRENLLKHLPETI-SQLTKLKRLDLGDNEIEDLPPYL-GYLPGLHELWLDHNQLQR 212
            .|..|.||.|..|.|..||..: .....|..|.|.:|.:.:||..| |.:.||.||||:..||:.
Human   240 RLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304

  Fly   213 LP-PELGLLTKLTYLDVS-ENRLEELP-NEISGLVSLTDLDLAQNLLEALPDGIAK-LSRLTILK 273
            || .....|::|.||.|: ..||..|| ....||..|..|.|..|.|.|||||:.: |.:|..:.
Human   305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVS 369

  Fly   274 LDQNRLQRLNDTL-GNCENMQELILTENFLSELPASI-GQMTKLNNLNVDRNA----------LE 326
            |.:|||:.|...| .|..:::.:.|..|.|..||..: |.:.:|..:.:..|:          |.
Human   370 LRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLG 434

  Fly   327 YLPLEIG--------QCANLG 339
            :|...:|        :||..|
Human   435 WLRQHLGLVGGEEPPRCAGPG 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 95/268 (35%)
leucine-rich repeat 18..38 CDD:275380 2/12 (17%)
LRR_8 37..95 CDD:290566 25/59 (42%)
leucine-rich repeat 39..61 CDD:275380 11/22 (50%)
leucine-rich repeat 62..84 CDD:275380 7/22 (32%)
LRR_8 84..138 CDD:290566 18/55 (33%)
leucine-rich repeat 85..107 CDD:275380 6/21 (29%)
leucine-rich repeat 108..130 CDD:275380 7/22 (32%)
LRR_8 129..187 CDD:290566 18/59 (31%)
leucine-rich repeat 131..153 CDD:275380 6/22 (27%)
leucine-rich repeat 154..176 CDD:275380 8/22 (36%)
leucine-rich repeat 177..199 CDD:275380 8/22 (36%)
LRR_8 198..256 CDD:290566 25/60 (42%)
leucine-rich repeat 200..222 CDD:275380 10/22 (45%)
leucine-rich repeat 223..245 CDD:275380 10/23 (43%)
LRR_8 267..325 CDD:290566 16/69 (23%)
leucine-rich repeat 269..289 CDD:275380 7/20 (35%)
leucine-rich repeat 292..314 CDD:275380 6/22 (27%)
leucine-rich repeat 315..337 CDD:275380 6/39 (15%)
LRR_4 337..375 CDD:289563 1/3 (33%)
leucine-rich repeat 361..382 CDD:275380
PDZ 728..816 CDD:214570
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
GP5NP_004479.1 LRR 1 75..96
LRR_RI <76..230 CDD:238064 39/119 (33%)
LRR_8 76..134 CDD:290566 9/23 (39%)
leucine-rich repeat 76..99 CDD:275380
LRR 2 99..120 2/9 (22%)
leucine-rich repeat 100..123 CDD:275380 2/12 (17%)
LRR 3 123..144 10/20 (50%)
leucine-rich repeat 124..147 CDD:275380 11/22 (50%)
LRR_8 147..206 CDD:290566 19/58 (33%)
LRR 4 147..168 6/20 (30%)
leucine-rich repeat 148..171 CDD:275380 7/22 (32%)
LRR_RI 163..400 CDD:238064 81/236 (34%)
LRR 5 171..193 7/21 (33%)
leucine-rich repeat 172..195 CDD:275380 7/22 (32%)
LRR_8 195..254 CDD:290566 18/58 (31%)
LRR 6 195..216 6/20 (30%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
LRR 7 219..240 5/20 (25%)
leucine-rich repeat 220..243 CDD:275380 6/22 (27%)
LRR_8 242..302 CDD:290566 22/59 (37%)
LRR 8 243..264 8/20 (40%)
leucine-rich repeat 244..267 CDD:275380 8/22 (36%)
LRR 9 267..288 7/20 (35%)
leucine-rich repeat 268..291 CDD:275380 8/22 (36%)
LRR 10 291..312 10/20 (50%)
leucine-rich repeat 292..315 CDD:275380 10/22 (45%)
LRR_8 314..375 CDD:290566 24/60 (40%)
leucine-rich repeat 316..338 CDD:275380 8/21 (38%)
LRR 11 340..361 10/20 (50%)
leucine-rich repeat 341..364 CDD:275380 11/22 (50%)
LRR_8 364..421 CDD:290566 15/56 (27%)
LRR 12 364..385 7/20 (35%)
leucine-rich repeat 365..388 CDD:275380 8/22 (36%)
LRR 13 388..409 5/20 (25%)
leucine-rich repeat 389..410 CDD:275380 6/20 (30%)
LRRCT 421..472 CDD:214507 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 469..498
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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