DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Frmpd2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_036014873.1	Gene:	Frmpd2 / 268729	MGIID:	2685472	Length:	1383	Species:	Mus musculus

Alignment Length:	1448	Identity:	292/1448 - (20%)
Similarity:	467/1448 - (32%)	Gaps:	423/1448 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 VAPTGVQGGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRV----GFQV 610
            |.|..:...:.|..|..::|....||.........|.::|.|.|..|...:.....:    ||:|
Mouse    48 VCPWSLLLSAAGGLSFQDHVSHIEAAPFKAPELLQGSNEEGQPDASQMHVYSLGMTLYWSAGFRV 112

  Fly   611 EGEDDDFYKRPPK--LHRRDTPHHL-------KNKRVQHLTDKQASEILANALASQERNDTTPQH 666
                      ||.  |..::..|.|       :.:|.|.|   ||  :|......||.....|..
Mouse   113 ----------PPNQPLQLQEPVHSLLLAMCEDQPRRRQPL---QA--VLEACRIHQEEVAVYPAP 162

  Fly   667 S------LSGKVTSPIEEEEQLEVEQEQQQQQQQ--------HPFDSSLSPISAGKTAEASTDPD 717
            :      |.|.|...|.|.|:..||:...:|:.:        |..|..    |.|..|..:..|.
Mouse   163 ASLHISRLVGLVLGTISEVERRVVEENACEQRNRSCSLRSRLHQADGE----SPGAPASDALQPR 223

  Fly   718 NL---DGVTELRLEQYEIH-----IERTAAGLG--------------LSIAGGKGSTPFKGDDDG 760
            .:   ...|:..||:...|     :..|.||.|              :.:|..:.|.|.......
Mouse   224 RVSERSAETQSSLERCTAHSRNSFVNSTFAGAGPCDCEESPWYGSEPMLLAEAESSQPATSSPRN 288

  Fly   761 IFISR---------VTEAGPA----DLAGLKVGDK-----------VIKVNG-IVVVDADHYQAV 800
             |:.|         :..||.|    .|.|..|..|           |:.:|| .:.|..|
Mouse   289 -FLQRKGKFSRPEFILLAGEAPVTLHLPGSIVTKKGKSYLALRDLCVVLLNGRCLEVKCD----- 347

  Fly   801 QVLKACGAVLVLVV---QREVTRLIGHPVFSEDGSVSQISVETRPLVADAP-------PAASIS- 854
             :....|||...|:   ..|.|...| ..:.|......:..:|| |...||       |..|:.
Mouse   348 -MESTAGAVFNAVMSFANLEETTYFG-LAYVEGEEFFFLDKDTR-LCKVAPEGWREQHPKGSVDT 409

  Fly   855 -----------------------HERYIPAPIEIVPQQQHLQQQQQQPIQQVA--------PTHS 888
                                   |:.|:....:|:.::.:...:....:..:|        |...
Mouse   410 FTLFLRIRFFVGHYRLLRHSLTRHQFYLQLRKDILEERLYCNDETLLQLGVLALQAEFGSYPKEQ 474

  Fly   889 YSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPP 953
            ..|..:.      .:|..:              |...|: ..|.||.|:    ..|......|.|
Mouse   475 VEGKAYF------RIQDYI--------------PARLIE-RMTAIRVQV----EVSEMHRLSSAP 514

  Fly   954 FKDDCDGIFISRITE----GGLAYR--------DGKIMVGDRVMAINGNDMTEAHHDAAVACLTE 1006
            :.:|.:..|:..:.:    |.|.:|        :||:.:|   :...|..:.|......:|....
Mouse   515 WGEDAELEFLEIVQQLPEYGVLVHRVSPEKKRPEGKMALG---VCTKGIIVYEVRGSRRIATSQF 576

  Fly  1007 PQRFVRLV-LQREYRGPLEPPTSPRSPAVLNSLSPSGYL---------------ANRPANFSRSV 1055
            |.|...:: ..|:........|..:...|.||.....||               :..|::.....
Mouse   577 PWRETGMISTHRKKLTITSSTTGKKYTFVTNSSKTCKYLLGLCSSQHWFNAQTGSKHPSHRFTGQ 641

  Fly  1056 VEVEQPYKYNTLATTTPTPKPTV-PASISNNNNTLP--SSKTNGFATAAAATIDSSTGQPVPAPR 1117
            .:..|....::...|...|...: ..|.|.|...:|  ...|.|   ....::::..|...|...
Mouse   642 DKFAQIASLSSAHQTQANPITWIQKLSCSENELCVPRLQDATGG---QLGTSMENKQGFKEPGKE 703

  Fly  1118 RTNSVPMGDGD----IG------------------AGSTTSG--------DS-GEAQPSSLRPLT 1151
            |..|.|...|:    ||                  |||...|        || ..:|.|..:.|.
Mouse   704 RIGSSPYTGGEQLHSIGLNQKPAQTVFGTAGHSMCAGSNCLGRRTQICCFDSVSGSQNSKRKGLF 768

  Fly  1152 SDDFQAMI-------PAH-------------------FLS----GGSQHQVHVARP-------NE 1179
            .:..|.::       |.|                   |:|    ||...:....:|       |.
Mouse   769 GEPNQDIVCVMLKRDPVHGFGFVINEGEDAEQTRSGIFISSLIPGGPAERAKKIKPGGKILALNH 833

  Fly  1180 VGVSAVTVNV------NKPQPDLPMFPAAPTEL-GRV-----TETITKSTFTETVMTR------- 1225
            :.:...|.::      |.|. |:.:..:.|..: |.:     ..|.:...|...:::.
Mouse   834 ISLEGFTFSMAVRMIQNSPD-DMELIISQPKGVCGTIHSEEKNSTASSGMFCTDILSNRCQGRQS 897

  Fly  1226 ---------ITDNQLAE--------PLISEE-----VVLPKNQGSLGFSIIGGTDHSCVPFGTRE 1268
                     :...::|:        ||.:..     |.|.|..|:||||:.||.:.| ||.|
Mouse   898 PHIHDQDRSVRGTEMAQGAGSCPPSPLQTNTGEIYFVELVKEDGTLGFSVTGGINTS-VPHG--- 958

  Fly  1269 PGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQH------ 1327
             ||::..|:|||.|:|.|::..|||:|:|:...:...||:.||..|..||...:|.::.
Mouse   959 -GIYVKSIIPGGPAAKEGQILQGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVARLVLERRGPRAA 1022

  Fly  1328 -------DPL------------PPGFQEVLLSKAEGERLGMHIKGGLNG--------QRGNPADP 1365
                   |.:            .||.....:|..:|.:..:.:|....|        :|||....
Mouse  1023 PQCPSADDRMGDVHMAVSLVTARPGRPASSVSVTDGPKFEVKLKKNSRGLGFSFVQMERGNCIHT 1087

  Fly  1366 SDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDK 1430
            ..:.|.:.::.....|...|.:..|..:|.|||..:.|.:.|:.:::||.|..|:.|::|:
Mouse  1088 KSDLVRIKRLFPGQPAEEHGAIAAGDIILAVNGKPIEGLAFQEVLHLLRGAPEEVTLLLCR---- 1148

  Fly  1431 SNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFA 1495
                ...|....|..|: .:...||..|. :.|:..|||.|     .|||.|::.|.....|...
Mouse  1149 ----PPPGILPEMEPGW-QTPELSGDQRL-TMATCAGSEQS-----PSLDQEDNWRDSTSLDAGE 1202

  Fly  1496 SQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALI 1560
            ...|      ||.........|.|......|.|.|.:.|:.:...|.... ..|:|||..|
Mouse  1203 GLSP------GPESSYKDVRQVKGDREKERPWAKSWMHPMESHPHVCKLH-PEPETPALAT---- 1256

  Fly  1561 HAEQQAHQQ-QQQTQLAPLGQEKSTQEKVLEIVR-AADAFTTVPPKSPSEHHEQDKIQKTTTVVI 1623
            ..|:...|. .....:..||.        ||:.| .||..|...|:|.|           .||..
Mouse  1257 SLEKDMRQNCYSVCDIRRLGS--------LELDRDGADGATCFLPESSS-----------LTVDY 1302

  Fly  1624 SKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSP---AVPASTPGSAPVLPAVAVQTQTQTTST 1685
            .::.     |..:..|..|.......|:|...|.|   ::.|....|.|          .::..:
Mouse  1303 EEYL-----TLTSASAGQLPCEECLEADSETIPLPQFCSLGALLKSSLP----------EESQGS 1352

  Fly  1686 EKDEEEESQLQSTPASRD 1703
            |.|.|:..:    |..||
Mouse  1353 ESDWEDLDE----PVDRD 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	27/134 (20%)
		PDZ_signaling	931..1016	CDD:238492	20/97 (21%)
		PDZ	1239..1329	CDD:214570	36/107 (34%)
		PDZ_signaling	1336..1425	CDD:238492	22/96 (23%)
Frmpd2	XP_036014873.1	PKc_like	6..188	CDD:419665	36/154 (23%)
		Ubiquitin_like_fold	329..422	CDD:421700	20/100 (20%)
		B41	334..538	CDD:214604	40/236 (17%)
		PH-like	534..635	CDD:418428	18/103 (17%)
		PDZ_signaling	775..859	CDD:238492	12/84 (14%)
		PDZ	930..1018	CDD:214570	36/92 (39%)
		PDZ	1061..1150	CDD:214570	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910