DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Lrrcc1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001094115.3	Gene:	Lrrcc1 / 266808	RGDID:	628722	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	174/900 - (19%)
Similarity:	325/900 - (36%)	Gaps:	241/900 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1640 APLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQL---QSTPAS 1701
            :||:|:..|..::..||          ...|||.:     .:.|||.::....|.|   .|.|..
  Rat   227 SPLNISEDEVVDNMSAP----------PIDVLPPL-----EEFTSTPEENVLTSLLSACSSEPEK 276

  Fly  1702 RDGAEEQQEEVRAKPTPTKVPKSVSD-KKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQEE 1765
            .:.....|.|::.:....::.:.::: .....::..|...:|.:.||     ::.:.....|:|.
  Rat   277 INHENNFQNEMKLQKLDDQILQLLNETNNSLIDNVPEKDLRPKRDTD-----ITSESDYGNRKEC 336

  Fly  1766 ERKIA----------TLR----RDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEE 1816
            .||::          |::    .:||:....:.|..:.:...:.....:|..:..:..:..:|:.
  Rat   337 SRKVSRRTKIPYYTRTIQSIKHHNKNNGAFVSCNRKMRQPYLRDLYVRSSLVNCNNLREVDEQKN 401

  Fly  1817 GIARGD---SVDN---AALGHFDDAEDMR-TAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTA 1874
            |:.:.|   |.||   :.:...|...:|| .|:.....:.....::.||..:.|.:.|.....|
  Rat   402 GMIKVDKSASNDNTYRSLVEQLDQEREMRWKAEQTEKKLMDYIDELHKQANEKKDVHSQAIITT- 465

  Fly  1875 LDPPKPSLLPKPKVKV---VIPPALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQQPEPDSP 1936
             |..|.::..:...|.   ||...||..:|:..::..:.:.||           |.|
  Rat   466 -DRLKDAIFKERHCKAQLEVIVHRLQNEIKKLTIELMKARDQQ-----------EDH-------- 510

  Fly  1937 SAAGGSRIPVRTLKAERRALTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEK 2001
                     :|.|:...|||....:|.....:..::.::..:.|.|.|.  ......|:.:..||
  Rat   511 ---------IRHLRTLERALEKMEKQKAQQQQAQMRLIQEVELKASAAD--REINLLRTSLRQEK 564

  Fly  2002 RASWRAARLRSLEQ-------------GAVEAQDVIKNMRKMTDDLITHESRASEVETCKERIIS 2053
            ....:...|.:|::             ...|.||.:  .::::.:...||   .||:..:|:|..
  Rat   565 EQVQQLHDLLALKEQEHRQEIETREFFNDAEFQDAL--TKRLSKEERKHE---QEVKEYQEKINI 624

  Fly  2054 LELQVPETEDEGKLDDTQPPLELEADDFQDDEDDDDDDDDEDDFEDEDEEEDTASIVTVQANNEK 2118
            |..|..:.|:|.::     .|.:||..|:         |.:|.|||         :.|..|.::.
  Rat   625 LNQQYLDLENEFRI-----ALTVEARRFK---------DVQDGFED---------VATELAKSKH 666

  Fly  2119 LFL---RHDSDTYGPSSIESVASGKVRIKPTPLS----LHQ----TLAKETTIVEVLNPVIGGDG 2172
            ..:   |.::::   ||:....:..|:.:.|.||    |.|    .|..:...:|:|..    |.
  Rat   667 ALIWAQRKENES---SSLIKDLTSMVKEQKTKLSEVCKLKQEAAANLQNQINTLEILIE----DD 724

  Fly  2173 SARTI------HVSGGLPFDEDAFEQGAVAVLRSETFVL-PGAAGGGRSELSLNAKMKTVLEELL 2230
            ..::|      |....| ..|.|.::..:..||:|..|. ...|..|.|......|::..:|.|.
  Rat   725 KQKSIQIELLKHEKNQL-ISELAAKESLIYGLRTERKVWGHELAYQGTSLSQSRGKLEAQIESLC 788

  Fly  2231 -ENERVKLNLQKSLEGEEGEDDDD---------EDENGSAYGDARDEEESAYGDAIDDVVDFGSA 2285
             |||    :|:|:     .|.|.|         ||:
  Rat   789 RENE----SLRKT-----HESDCDALRIKCKIIEDQ----------------------------- 815

  Fly  2286 TVTSRAANDKDDVKNGNQQLLEELIKDSNRNTIIAKLA-GQLSDDDEEDDDEEESSDSSDDDSD- 2348
            |.|.|...|....|:|..::|:|.|      |||.|.: .||::...:.|...|..:..::..:
  Rat   816 TETIRKLKDGLQEKDGQIKMLQEQI------TIIEKCSQEQLNEKTSQLDSIVEKLERHNERKEK 874

  Fly  2349 ----------DSDEEDNAQQQLNVTYVQGAQVIENLNTLATGGKLQKSQTYTAIKQAEEPKEEDT 2403
                      :.:|...|...||..:....:::.||.|           ....:|:..|.||:..
  Rat   875 LKQQLKAKELELEEIRKAYSTLNKKWHDKGELLSNLET-----------QVKEVKEKFENKEKKL 928

  Fly  2404 KLEEDPSAEKPCGADTLAKLQAEQRALAEISKQLRKSVEDLLSADGETVVETQRT 2458
            :.|.|.|.|  ...|.:.|||               :::|......:.:||..:|
  Rat   929 RAERDRSLE--LQKDAVEKLQ---------------NMDDAFKRQVDAIVEAHQT 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrrcc1	NP_001094115.3	PPP1R42	25..197	CDD:411060
		leucine-rich repeat	40..61	CDD:275378
		leucine-rich repeat	62..83	CDD:275378
		leucine-rich repeat	84..105	CDD:275378
		leucine-rich repeat	106..131	CDD:275378
		leucine-rich repeat	132..145	CDD:275378
		leucine-rich repeat	158..188	CDD:275380
		Smc	426..>758	CDD:224117	78/399 (20%)
		Smc	<639..1020	CDD:224117	88/425 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910