DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and LRRC32

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001122394.1 Gene:LRRC32 / 2615 HGNCID:4161 Length:662 Species:Homo sapiens


Alignment Length:493 Identity:139/493 - (28%)
Similarity:185/493 - (37%) Gaps:128/493 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 EEILRYSRTLEELFLDANHIRDLPKNFFR-LHRLRKLGLSDNEIGRLPPDIQN--FE---NLVEL 88
            |.:|..:.:|..|.|..|.:..|.::.|| :..|.:|.|..|.:    .||::  ||   .|..|
Human   142 ERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVL----MDIEDGAFEGLPRLTHL 202

  Fly    89 DVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLK---NLTVLGLNDMSLTTLPADFGS 150
            ::|||.:..|.|  ..||.|:|.|.|.|.|....:. ||.:   .||.|.|.:..|...| |..:
Human   203 NLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFQTA-SQPQAEFQLTWLDLRENKLLHFP-DLAA 263

  Fly   151 LTQLESLELRENLLK------------HLPE---------------TISQLTKLKRLDLGDNEIE 188
            |.:|..|.|..||::            |.|.               :...|::|..|||..||||
Human   264 LPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328

  Fly   189 DLPP-------------------------YLGYLPGLHELWLDHNQLQRLPPELG--LLTKLTYL 226
            .:|.                         .||.||.|..|.|.||.|:.|  |||  .|..|..|
Human   329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL--ELGARALGSLRTL 391

  Fly   227 DVSENRLEELP-----------------NEI-----------------SGLVSLTDLDLAQNLLE 257
            .:..|.|.:||                 |.:                 ||:.||..|.|..|.:|
Human   392 LLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIE 456

  Fly   258 ALPDGIAKLSRLTILKLDQN-RLQRLNDTLGNCE-NMQELILTENFLSELPASIGQMTKLNNLNV 320
            .|..|....:.||.|.|..| .|:.....||..| :::.|.|..|.|..|...:.....|..||:
Human   457 LLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNL 521

  Fly   321 DRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPEL--GNCTVLHVLDVSGNQLLYLPYSLVNLQL 383
            ..|.|.:||... |..:|.||.||:|....||...  |..|.|..|.:.||.|......      
Human   522 AENRLSHLPAWT-QAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNG------ 579

  Fly   384 KAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQE 421
               ||:....|.    :.|.||   .|.|.|....|:|
Human   580 ---WLAAQLHQG----RVDVDA---TQDLICRFSSQEE 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 97/350 (28%)
leucine-rich repeat 18..38 CDD:275380 2/7 (29%)
LRR_8 37..95 CDD:290566 20/63 (32%)
leucine-rich repeat 39..61 CDD:275380 7/22 (32%)
leucine-rich repeat 62..84 CDD:275380 8/26 (31%)
LRR_8 84..138 CDD:290566 21/56 (38%)
leucine-rich repeat 85..107 CDD:275380 8/21 (38%)
leucine-rich repeat 108..130 CDD:275380 8/24 (33%)
LRR_8 129..187 CDD:290566 21/87 (24%)
leucine-rich repeat 131..153 CDD:275380 8/21 (38%)
leucine-rich repeat 154..176 CDD:275380 8/48 (17%)
leucine-rich repeat 177..199 CDD:275380 12/46 (26%)
LRR_8 198..256 CDD:290566 26/93 (28%)
leucine-rich repeat 200..222 CDD:275380 11/23 (48%)
leucine-rich repeat 223..245 CDD:275380 9/55 (16%)
LRR_8 267..325 CDD:290566 18/59 (31%)
leucine-rich repeat 269..289 CDD:275380 8/20 (40%)
leucine-rich repeat 292..314 CDD:275380 5/21 (24%)
leucine-rich repeat 315..337 CDD:275380 8/21 (38%)
LRR_4 337..375 CDD:289563 15/39 (38%)
leucine-rich repeat 361..382 CDD:275380 5/20 (25%)
PDZ 728..816 CDD:214570
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
LRRC32NP_001122394.1 LRR_RI 19..277 CDD:238064 46/142 (32%)
leucine-rich repeat 31..50 CDD:275380
PLN00113 49..>574 CDD:215061 127/442 (29%)
LRR 1. /evidence=ECO:0000255 50..73
leucine-rich repeat 51..74 CDD:275380
LRR 2. /evidence=ECO:0000255 74..95
leucine-rich repeat 75..98 CDD:275380
LRR 3. /evidence=ECO:0000255 98..119
leucine-rich repeat 99..125 CDD:275380
LRR 4. /evidence=ECO:0000255 125..145 1/2 (50%)
leucine-rich repeat 126..150 CDD:275380 2/7 (29%)
LRR 5. /evidence=ECO:0000255 150..171 6/20 (30%)
leucine-rich repeat 151..174 CDD:275380 7/22 (32%)
LRR 6. /evidence=ECO:0000255 174..195 7/24 (29%)
leucine-rich repeat 175..198 CDD:275380 8/26 (31%)
LRR 7. /evidence=ECO:0000255 198..219 8/22 (36%)
leucine-rich repeat 199..219 CDD:275380 8/21 (38%)
leucine-rich repeat 220..244 CDD:275380 8/24 (33%)
LRR 8. /evidence=ECO:0000255 220..240 8/20 (40%)
LRR 9. /evidence=ECO:0000255 244..265 7/21 (33%)
leucine-rich repeat 245..266 CDD:275380 8/21 (38%)
LRR 10. /evidence=ECO:0000255 266..286 5/19 (26%)
LRR 11. /evidence=ECO:0000255 316..339 9/22 (41%)
leucine-rich repeat 317..340 CDD:275380 9/22 (41%)
LRR 12. /evidence=ECO:0000255 340..363 2/22 (9%)
leucine-rich repeat 341..364 CDD:275380 3/22 (14%)
LRR 13. /evidence=ECO:0000255 364..385 10/22 (45%)
leucine-rich repeat 365..387 CDD:275380 11/23 (48%)
LRR 14. /evidence=ECO:0000255 387..408 6/20 (30%)
leucine-rich repeat 388..411 CDD:275380 6/22 (27%)
LRR 15. /evidence=ECO:0000255 411..432 1/20 (5%)
leucine-rich repeat 412..444 CDD:275380 3/31 (10%)
LRR 16. /evidence=ECO:0000255 444..465 8/20 (40%)
leucine-rich repeat 445..463 CDD:275380 7/17 (41%)
LRR 17. /evidence=ECO:0000255 467..488 7/20 (35%)
leucine-rich repeat 468..492 CDD:275380 9/23 (39%)
LRR 18. /evidence=ECO:0000255 492..513 5/20 (25%)
leucine-rich repeat 493..515 CDD:275380 5/21 (24%)
PLN03150 <496..654 CDD:178695 39/129 (30%)
LRR 19. /evidence=ECO:0000255 515..536 8/21 (38%)
leucine-rich repeat 516..537 CDD:275380 8/21 (38%)
LRR 20. /evidence=ECO:0000255 537..558 8/20 (40%)
leucine-rich repeat 538..559 CDD:275380 8/20 (40%)
leucine-rich repeat 563..575 CDD:275378 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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