DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and LRRC57

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_694992.2 Gene:LRRC57 / 255252 HGNCID:26719 Length:239 Species:Homo sapiens


Alignment Length:224 Identity:72/224 - (32%)
Similarity:112/224 - (50%) Gaps:28/224 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 VLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYL-GY 196
            |..|.|..||..|||...||                      :.|:.:||.:|:||.|||.| |.
Human    18 VFQLKDRGLTEFPADLQKLT----------------------SNLRTIDLSNNKIESLPPLLIGK 60

  Fly   197 LPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPD 261
            ...|..|.|::|:|..||.|:..|.||..|.::.|.|.|||:....|.:|..|.|:.|.|.|||.
Human    61 FTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPP 125

  Fly   262 GIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALE 326
            .:..|..|.::.|.:|:::.:.|::|..: :.||.|.:|.:|::...|....:|..|.::.|.||
Human   126 QLCSLRHLDVMDLSKNQIRSIPDSVGELQ-VIELNLNQNQISQISVKISCCPRLKILRLEENCLE 189

  Fly   327 --YLPLEIGQCANLGVLSLRDN--KLKKL 351
              .||..|...:.:.:|::..|  ::|||
Human   190 LSMLPQSILSDSQICLLAVEGNLFEIKKL 218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 51/150 (34%)
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380
LRR_8 84..138 CDD:290566 2/4 (50%)
leucine-rich repeat 85..107 CDD:275380
leucine-rich repeat 108..130 CDD:275380
LRR_8 129..187 CDD:290566 14/53 (26%)
leucine-rich repeat 131..153 CDD:275380 9/19 (47%)
leucine-rich repeat 154..176 CDD:275380 0/21 (0%)
leucine-rich repeat 177..199 CDD:275380 11/22 (50%)
LRR_8 198..256 CDD:290566 22/57 (39%)
leucine-rich repeat 200..222 CDD:275380 9/21 (43%)
leucine-rich repeat 223..245 CDD:275380 8/21 (38%)
LRR_8 267..325 CDD:290566 14/57 (25%)
leucine-rich repeat 269..289 CDD:275380 5/19 (26%)
leucine-rich repeat 292..314 CDD:275380 6/21 (29%)
leucine-rich repeat 315..337 CDD:275380 8/23 (35%)
LRR_4 337..375 CDD:289563 5/17 (29%)
leucine-rich repeat 361..382 CDD:275380
PDZ 728..816 CDD:214570
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
LRRC57NP_694992.2 PRK15370 <21..>211 CDD:185268 67/212 (32%)
LRR 1 39..60 10/20 (50%)
leucine-rich repeat 40..63 CDD:275380 11/22 (50%)
LRR 2 63..84 8/20 (40%)
leucine-rich repeat 64..86 CDD:275380 9/21 (43%)
LRR 3 86..107 8/20 (40%)
leucine-rich repeat 87..109 CDD:275380 8/21 (38%)
LRR 4 109..131 8/21 (38%)
leucine-rich repeat 110..132 CDD:275380 9/21 (43%)
LRR 5 132..153 5/20 (25%)
leucine-rich repeat 133..154 CDD:275380 5/20 (25%)
LRR 6 154..175 6/21 (29%)
leucine-rich repeat 155..177 CDD:275380 6/21 (29%)
LRR 7 177..197 7/19 (37%)
leucine-rich repeat 178..199 CDD:275380 8/20 (40%)
LRR 8 202..222 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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