DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Dlg1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	174/797 - (21%)
Similarity:	259/797 - (32%)	Gaps:	347/797 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 VQGGSEGASSTANNVKAATAAVVAELAATVGG-SDEVQDDDEQEDEFESDRRVGFQVEGEDDDFY 618
            ||.|:...|.:     .::|||.:|  :..|| |..|:....|::|.....|:..||
  Rat    76 VQPGNPWESGS-----LSSAAVTSE--SLPGGLSPPVEKYRYQDEEVLPSERISPQV-------- 125

  Fly   619 KRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVT----SPIEEE 679
                       |:.:....:.|:::|..|||                .::.|.|:    |||:..
  Rat   126 -----------PNEVLGPELVHVSEKSLSEI----------------ENVHGFVSHSHISPIKPT 163

  Fly   680 EQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDP-----DNLD-----GVTELRLEQYEIHI 734
            |.:.............|..:. ||:....|.:|:..|     |:|:     ..|:...|..||.:
  Rat   164 EAVPPSSPIVPVTPALPVPAE-SPVVLPSTPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITL 227

  Fly   735 ERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAG-LKVGDKVIKVNGIVVVDADHYQ 798
            ||..:|||.|||||. ..|..|||..|||:::...|.|...| |:|.|.:::||...|.|..|.:
  Rat   228 ERGNSGLGFSIAGGT-DNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSK 291

  Fly   799 AVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPI 863
            ||:.||..|:::.|.|:|.                             .|.:..|...:.|..|
  Rat   292 AVEALKEAGSIVRLYVKRR-----------------------------KPASEKIMEIKLIKGP- 326

  Fly   864 EIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQL 928

  Rat   327 ----------------------------------------------------------------- 326

  Fly   929 HTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMT 993
                      :|||||||||.|:.....| :.|::::|.|||.|::|||:.:||:::|:|...:.
  Rat   327 ----------KGLGFSIAGGVGNQHIPGD-NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLE 380

  Fly   994 EAHHDAAVACLTEPQRFVRLVLQRE----YRGPLEPP--TSPRSPAVLNSLSPSGYLANRPANFS 1052
            |..|:.||..|.....||.|.:.:.    ......||  |:..|.:|.|.:|||.||...||:
  Rat   381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQTPAS-- 443

  Fly  1053 RSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPR 1117
                    |.:|:                        |.||
  Rat   444 --------PARYS------------------------PISK------------------------ 452

  Fly  1118 RTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGV 1182
                ..:||.:|
  Rat   453 ----AVLGDDEI----------------------------------------------------- 460

  Fly  1183 SAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQG 1247
                                                     ||       ||   .:|||.:...
  Rat   461 -----------------------------------------TR-------EP---RKVVLHRGST 474

  Fly  1248 SLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVL 1312
            .|||:|:||.|..         |||||.|:.||.|...|:||.||||:.||..|:..|:|:.|..
  Rat   475 GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAA 530

  Fly  1313 ELLKPGDEIKLTIQHDP 1329
            .|...|..:.:..|:.|
  Rat   531 ALKNAGQAVTIVAQYRP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	38/88 (43%)
		PDZ_signaling	931..1016	CDD:238492	32/84 (38%)
		PDZ	1239..1329	CDD:214570	35/89 (39%)
		PDZ_signaling	1336..1425	CDD:238492
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492	36/84 (43%)
		PDZ_signaling	317..403	CDD:238492	35/162 (22%)
		PDZ_assoc	404..465	CDD:402299	25/226 (11%)
		PDZ	463..547	CDD:214570	37/95 (39%)
		SH3_DLG1	582..648	CDD:212964
		Guanylate_kin	748..926	CDD:395500
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306	27/152 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910