DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and SCRIB

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_874365.3 Gene:SCRIB / 23513 HGNCID:30377 Length:1655 Species:Homo sapiens


Alignment Length:2240 Identity:739/2240 - (32%)
Similarity:1007/2240 - (44%) Gaps:679/2240 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            |.||||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||||..||||
Human     1 MLKCIPLWR-CNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||||.||||::.||..||||||||||||:||:.||..::|::||||.||:.:||.||:||::
Human    65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            |..|.|||:||..||.|.|:|..|.:|||||||||.||.::|.|.||::||||.|::|.||..||
Human   130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .||.|.|||||.|||..||||||.|.:|..||||||||||||.|:.|||.||||.|:||||..||
Human   195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            |||.:|.:|:|||:|||||..:.:.:|:|||:.|||||||.|..||.|:|::|||.|||||||.|
Human   260 DGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            |.||.|||.|..|.|||||||:|..|||||.:.|.||||||:||:|..||::|.:|.|||:||:|
Human   325 EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAE 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSR-TVVKF---- 450
            ||:||:|.||.:.||.|||:||:|||||||....:..|....|.||.:.:..||| :|::|    
Human   390 NQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAP 454

  Fly   451 -----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKL-AETPT 509
                 :|||..||. ...|:.||||.:|  |..|..:|..|:|    ......::|:.| ||  .
Human   455 IGDEDAEEAAAEKR-GLQRRATPHPSEL--KVMKRSIEGRRSE----ACPCQPDSGSPLPAE--E 510

  Fly   510 ETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVA---PTG----VQGGSEGASSTAN 567
            |.|..|.:             |::...       .|:.:||:   |.|    .||||:       
Human   511 EKRLSAES-------------GLSEDS-------RPSASTVSEAEPEGPSAEAQGGSQ------- 548

  Fly   568 NVKAATAAVVAELAATVGGSDEVQDDDEQ------EDEF--ESDRRVGFQVEGEDDDFYKRP--- 621
                       :.|.|.||.::.::|.::      ||..  ..||.:   .||:.:..:..|   
Human   549 -----------QEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREI---EEGQPEAPWTLPGGR 599

  Fly   622 PKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTP------QHSLSGKVTSPIEEEE 680
            .:|.|:||||:.|:.::..|...:|...|...:.........|      .|:.........||||
Human   600 QRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEE 664

  Fly   681 QLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG--------------------VTEL 725
            :....||:::::::.         :..:..||||:.::.:|                    :...
Human   665 EEGSPQEEEEEEEEE---------NRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720

  Fly   726 RLEQYE--IHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNG 788
            |:|:.|  :.|.|...|||:||||||||||:||||:|||||||:|.|||..||::||||:::|||
Human   721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNG 785

  Fly   789 IVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASI 853
            :.:..|:|::||:.|:..|..:.:.|.||  |:: .|         :.:|...||          
Human   786 VALQGAEHHEAVEALRGAGTAVQMRVWRE--RMV-EP---------ENAVTITPL---------- 828

  Fly   854 SHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNG 918
                                    :|....:|.....|.:                   .|.|..
Human   829 ------------------------RPEDDYSPRERRGGGL-------------------RLPLLP 850

  Fly   919 REAPLSYIQLHTT-LIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGD 982
            .|:|....|.|.. |.|.:  :||||||||||||.|::....|||:|||.|||.|:|.|.:.|||
Human   851 PESPGPLRQRHVACLARSE--RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913

  Fly   983 RVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANR 1047
            ||::|||.|:|||.||.||:.||.....:.|:|:||..|||.|                      
Human   914 RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPP---------------------- 956

  Fly  1048 PANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQP 1112
                                   :|.|..:.|                   |||.||...:|..|
Human   957 -----------------------SPLPHSSPP-------------------TAAVATTSITTATP 979

  Fly  1113 VPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARP 1177
                                                                             
Human   980 ----------------------------------------------------------------- 979

  Fly  1178 NEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVL 1242
               ||           |.||..  ||:.|....|                     .|...||:.|
Human   980 ---GV-----------PGLPSL--APSLLAAALE---------------------GPYPVEEIRL 1007

  Fly  1243 PKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATH 1307
            |:..|.||.||:||:|||..|||.:|||:|||.::|.|:|::.| ||:|||||.||..||..|||
Human  1008 PRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071

  Fly  1308 QDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFV 1372
            |:||..||:|..|:.|.::.||.|||.:|:.:.||.|||||:.|:||..|..|||.||:|||:|:
Human  1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFI 1136

  Fly  1373 SKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSI 1437
            ||::..|||.|||||:||:||||||..||||.:|.:||.:||:.|:.:.::||.|::.|.     
Human  1137 SKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAST----- 1196

  Fly  1438 GQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQ 1502
            ..|..:|.|..::...:|...:.|           .:|:||:|.|                   .
Human  1197 DAALEVSPGVIANPFAAGIGHRNS-----------LESISSIDRE-------------------L 1231

  Fly  1503 QPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAH 1567
            .|.||           |.....|                                     .|..|
Human  1232 SPEGP-----------GKEKELP-------------------------------------GQTLH 1248

  Fly  1568 QQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNP 1632
            ...:.|:.|..|.:                    |.|                  :....|...|
Human  1249 WGPEATEAAGRGLQ--------------------PLK------------------LDYRALAAVP 1275

  Fly  1633 TTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQS 1697
            :..:....|...||.:.|.|..:||...|.|.| |...|||...|......:.......|.....
Human  1276 SAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPP-SPDELPANVKQAYRAFAAVPTSHPPEDAPAQ 1339

  Fly  1698 TPASRDGAEEQQEEVRAKPTPTKVPKSVS--DKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEK 1760
            .|.               |.|...|:.:|  :::::||  :|.:....:...|..|.:..|::.|
Human  1340 PPT---------------PGPAASPEQLSFRERQKYFE--LEVRVPQAEGPPKRVSLVGADDLRK 1387

  Fly  1761 LRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVD 1825
            :::||.||:    :.|.:::|        ::||                     |.|.....::|
Human  1388 MQEEEARKL----QQKRAQML--------REAA---------------------EAGAEARLALD 1419

  Fly  1826 NAALGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLLPKPKVKV 1890
            ...||. ::.||                         :|...:.|:||:                
Human  1420 GETLGE-EEQED-------------------------EQPPWASPSPTS---------------- 1442

  Fly  1891 VIPPALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQQPEPDSPSAAGGSRIPVRTLKAERRA 1955
                                  :||                 |.||...||. .||||.||||| 
Human  1443 ----------------------RQS-----------------PASPPPLGGG-APVRTAKAERR- 1466

  Fly  1956 LTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVEA 2020
                          :.:||..| ..|.||.....:......:.|||||.|||||::||||.|:.|
Human  1467 --------------HQERLRVQ-SPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRA 1516

  Fly  2021 QDVIKNMRKMTDDLITHESRASEVETCK---ERIISLELQVP-----ETEDEGKLDDTQP---PL 2074
            |.|:              ||:.|....:   ||:.......|     ..||.|....|.|   ||
Human  1517 QMVL--------------SRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPL 1567

  Fly  2075 ELEADDFQD----DEDDDDDDDDEDDFEDE------------DEEEDTASIVTVQANNEKLFLRH 2123
            ..:..|::.    .......|....||.:|            .||:...::|        |..|.
Human  1568 SGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALV--------LLGRP 1624

  Fly  2124 DSDTYGP------SSIESVASGKVRIKPTP 2147
            .....||      ||...|..|:..:.|.|
Human  1625 SPGAVGPEDVALCSSRRPVRPGRRGLGPVP 1654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 179/269 (67%)
leucine-rich repeat 18..38 CDD:275380 16/19 (84%)
LRR_8 37..95 CDD:290566 43/57 (75%)
leucine-rich repeat 39..61 CDD:275380 16/21 (76%)
leucine-rich repeat 62..84 CDD:275380 17/21 (81%)
LRR_8 84..138 CDD:290566 32/53 (60%)
leucine-rich repeat 85..107 CDD:275380 16/21 (76%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
LRR_8 129..187 CDD:290566 33/57 (58%)
leucine-rich repeat 131..153 CDD:275380 12/21 (57%)
leucine-rich repeat 154..176 CDD:275380 14/21 (67%)
leucine-rich repeat 177..199 CDD:275380 12/21 (57%)
LRR_8 198..256 CDD:290566 41/57 (72%)
leucine-rich repeat 200..222 CDD:275380 16/21 (76%)
leucine-rich repeat 223..245 CDD:275380 16/21 (76%)
LRR_8 267..325 CDD:290566 35/57 (61%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 12/21 (57%)
leucine-rich repeat 315..337 CDD:275380 16/21 (76%)
LRR_4 337..375 CDD:289563 24/37 (65%)
leucine-rich repeat 361..382 CDD:275380 12/20 (60%)
PDZ 728..816 CDD:214570 48/89 (54%)
PDZ_signaling 931..1016 CDD:238492 46/85 (54%)
PDZ 1239..1329 CDD:214570 48/89 (54%)
PDZ_signaling 1336..1425 CDD:238492 49/88 (56%)
SCRIBNP_874365.3 Sufficient for targeting to adherens junction and to inhibit cell proliferation 1..818 404/879 (46%)
LRR_RI 12..232 CDD:238064 145/219 (66%)
leucine-rich repeat 14..37 CDD:275380 18/22 (82%)
leucine-rich repeat 38..60 CDD:275380 16/21 (76%)
LRR 39..401 CDD:227223 233/361 (65%)
leucine-rich repeat 61..83 CDD:275380 17/21 (81%)
leucine-rich repeat 84..106 CDD:275380 16/21 (76%)
leucine-rich repeat 107..129 CDD:275380 13/21 (62%)
leucine-rich repeat 130..152 CDD:275380 12/21 (57%)
leucine-rich repeat 153..175 CDD:275380 14/21 (67%)
leucine-rich repeat 176..198 CDD:275380 12/21 (57%)
leucine-rich repeat 199..221 CDD:275380 16/21 (76%)
leucine-rich repeat 268..290 CDD:275380 11/21 (52%)
leucine-rich repeat 291..313 CDD:275380 12/21 (57%)
leucine-rich repeat 314..336 CDD:275380 16/21 (76%)
leucine-rich repeat 360..381 CDD:275380 12/20 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..440 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 459..604 46/194 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..702 13/77 (17%)
Interaction with ARHGEF7. /evidence=ECO:0000269|PubMed:15182672 717..1229 253/761 (33%)
PDZ 725..813 CDD:214570 47/87 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..853 7/78 (9%)
PDZ_signaling 860..947 CDD:238492 47/88 (53%)
PDZ_signaling 1002..1090 CDD:238492 49/88 (56%)
PDZ_signaling 1098..1189 CDD:238492 49/90 (54%)
Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5. /evidence=ECO:0000269|PubMed:18042258 1105..1117 8/11 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1227..1246 7/85 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1489 69/360 (19%)
AbLIM_anchor 1555..>1593 CDD:292800 7/37 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 252 1.000 Domainoid score I2103
eggNOG 1 0.900 - - E33208_3BA7S
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 781 1.000 Inparanoid score I527
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48681
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 1 1.000 - - FOG0005473
OrthoInspector 1 1.000 - - otm42158
orthoMCL 1 0.900 - - OOG6_102427
Panther 1 1.100 - - LDO PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5064
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.880

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