DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and LRRC8B

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001127948.1	Gene:	LRRC8B / 23507	HGNCID:	30692	Length:	803	Species:	Homo sapiens

Alignment Length:	356	Identity:	116/356 - (32%)
Similarity:	168/356 - (47%)	Gaps:	40/356 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EFVDKRHCSLPQVPEEILRYSRT----LEEL-FLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRL 75
            |..:....||..:||..|..:.:    |:|| ...::.:.|.|...|....|:.|.|...|:|::
Human   438 ELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKI 502

  Fly    76 PPDIQNFENLVELDVSRNDIPDIP--------DDIKHLQSLQVADFSSNPIPK-----LPS---- 123
            |..:.:.:||.||.:|...:|:..        .|:|:|::|.:.. |.:.||:     |||
Human   503 PRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKL 566

  Fly   124 -------------GFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS--Q 173
                         ...::.||..|.|....|..:|....||..|..|:||||.||.:.|.||  .
Human   567 SLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQH 631

  Fly   174 LTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPN 238
            |..|..|.|..|.|..:|..:|.|..|.:|.||||.::.||.:|.|.|||.|||:|.|.|..:|.
Human   632 LQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPE 696

  Fly   239 EISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLS 303
            ||..|.:|....:..|.:|.||||:.:..:|..|.|.:|.|..|:..:|...|:..|.|..|:|.
Human   697 EIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLE 761

  Fly   304 ELPASIG--QMTKLNNLNVDRNALEYLPLEI 332
            .||..:.  |..|.|.|.|:.|.|..|||.:
Human   762 TLPPELEGCQSLKRNCLIVEENLLNTLPLPV 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	97/303 (32%)
		leucine-rich repeat	18..38	CDD:275380	5/19 (26%)
		LRR_8	37..95	CDD:290566	17/62 (27%)
		leucine-rich repeat	39..61	CDD:275380	6/22 (27%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	20/83 (24%)
		leucine-rich repeat	85..107	CDD:275380	8/29 (28%)
		leucine-rich repeat	108..130	CDD:275380	7/43 (16%)
		LRR_8	129..187	CDD:290566	24/59 (41%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	12/23 (52%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	25/57 (44%)
		leucine-rich repeat	200..222	CDD:275380	10/21 (48%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		LRR_8	267..325	CDD:290566	20/59 (34%)
		leucine-rich repeat	269..289	CDD:275380	7/19 (37%)
		leucine-rich repeat	292..314	CDD:275380	7/23 (30%)
		leucine-rich repeat	315..337	CDD:275380	8/18 (44%)
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
LRRC8B	NP_001127948.1	Pannexin_like	1..334	CDD:315247
		PLN00113	<428..>704	CDD:215061	85/266 (32%)
		LRR 1	464..486		6/21 (29%)
		leucine-rich repeat	465..488	CDD:275380	6/22 (27%)
		LRR 2	488..509		6/20 (30%)
		leucine-rich repeat	489..511	CDD:275380	6/21 (29%)
		LRR 3	511..532		6/20 (30%)
		leucine-rich repeat	512..539	CDD:275380	6/26 (23%)
		LRR 4	539..559		5/20 (25%)
		leucine-rich repeat	540..562	CDD:275380	6/22 (27%)
		LRR 5	562..582		1/19 (5%)
		leucine-rich repeat	563..609	CDD:275380	8/45 (18%)
		LRR	<578..788	CDD:227223	79/209 (38%)
		LRR 6	586..607		6/20 (30%)
		LRR 7	609..630		11/20 (55%)
		leucine-rich repeat	610..634	CDD:275380	12/23 (52%)
		LRR 8	634..655		7/20 (35%)
		leucine-rich repeat	635..657	CDD:275380	8/21 (38%)
		LRR 9	657..678		9/20 (45%)
		leucine-rich repeat	658..680	CDD:275380	10/21 (48%)
		LRR 10	680..701		11/20 (55%)
		leucine-rich repeat	681..703	CDD:275380	11/21 (52%)
		LRR 11	703..724		7/20 (35%)
		leucine-rich repeat	704..726	CDD:275380	7/21 (33%)
		LRR 12	726..747		7/20 (35%)
		leucine-rich repeat	727..749	CDD:275380	7/21 (33%)
		LRR 13	749..771		7/21 (33%)
		leucine-rich repeat	750..772	CDD:275380	6/21 (29%)
		leucine-rich repeat	773..796	CDD:275380	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910