DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and FLII

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_005256612.1	Gene:	FLII / 2314	HGNCID:	3750	Length:	1296	Species:	Homo sapiens

Alignment Length:	481	Identity:	131/481 - (27%)
Similarity:	215/481 - (44%)	Gaps:	56/481 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRN 93
            ||.: :...:|..|.|:...:..||:....|.:|..|.:|.|.:..|..::.:..:|..:....|
Human    26 PENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARAN 89

  Fly    94 DIPD--IPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPAD-FGSLTQLE 155
            .:.:  :||||..|..|.|.|.|.|.:.:.|......||:.||.|:..|:.|:|.. |.:||.|.
Human    90 SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLL 154

  Fly   156 SLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLL 220
            .|:|.||.|:.||..:.:|..|:.|.|..|      |.|            |.||::||....|.
Human   155 YLDLSENRLESLPPQMRRLVHLQTLVLNGN------PLL------------HAQLRQLPAMTALQ 201

  Fly   221 TKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDT 285
            |  .:|..::.....||..:.||.:|.|:||:.|.|..:|:.:..|..|..|.|..|::..|:..
Human   202 T--LHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264

  Fly   286 LGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY--LPLEIGQCANLGVLSLRDNKL 348
            :....:::.|.|:.|.|:.||::|.:::||..|.::.|.|::  ||..||:..||......:|.|
Human   265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNL 329

  Fly   349 KKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSENQSQPLLTFQPDTDAETGEQVL 412
            :.:|..|..|..|..|.::.|.|:.||.::..| :::.:.:.||   |.|...|.......|...
Human   330 ELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN---PNLVMPPKPADRAAEWYN 391

  Fly   413 SCYLLPQQ----EYQPITPARDLESDSEPFE---------------EREPSRTVVKFSEEATQEK 458
            ..:.|..|    ...|.|.|....:.|.|.:               :.:.::.|:|...:..|||
Human   392 IDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEK 456

  Fly   459 ETPFVRQNTPHPKDLKAKAQKLKVER 484
                   |....:...|:|...||.|
Human   457 -------NKKQEESADARAPSGKVRR 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	76/256 (30%)
		leucine-rich repeat	18..38	CDD:275380	2/8 (25%)
		LRR_8	37..95	CDD:290566	13/57 (23%)
		leucine-rich repeat	39..61	CDD:275380	6/21 (29%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR_8	84..138	CDD:290566	18/55 (33%)
		leucine-rich repeat	85..107	CDD:275380	7/23 (30%)
		leucine-rich repeat	108..130	CDD:275380	6/21 (29%)
		LRR_8	129..187	CDD:290566	24/58 (41%)
		leucine-rich repeat	131..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..176	CDD:275380	9/21 (43%)
		leucine-rich repeat	177..199	CDD:275380	6/21 (29%)
		LRR_8	198..256	CDD:290566	17/57 (30%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	5/21 (24%)
		LRR_8	267..325	CDD:290566	16/57 (28%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	8/23 (35%)
		LRR_4	337..375	CDD:289563	11/37 (30%)
		leucine-rich repeat	361..382	CDD:275380	7/21 (33%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
FLII	XP_005256612.1	LRR_RI	<2..139	CDD:238064	31/113 (27%)
		leucine-rich repeat	10..34	CDD:275380	2/8 (25%)
		LRR_8	33..91	CDD:290566	13/57 (23%)
		leucine-rich repeat	35..57	CDD:275380	6/21 (29%)
		leucine-rich repeat	58..80	CDD:275380	5/21 (24%)
		leucine-rich repeat	83..105	CDD:275378	6/21 (29%)
		LRR_RI	89..374	CDD:238064	95/307 (31%)
		leucine-rich repeat	106..128	CDD:275380	6/21 (29%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		LRR_8	131..186	CDD:290566	22/60 (37%)
		leucine-rich repeat	153..175	CDD:275380	9/21 (43%)
		leucine-rich repeat	176..199	CDD:275380	11/40 (28%)
		leucine-rich repeat	200..224	CDD:275380	7/25 (28%)
		LRR_8	223..281	CDD:290566	16/57 (28%)
		leucine-rich repeat	225..247	CDD:275380	8/21 (38%)
		leucine-rich repeat	248..270	CDD:275380	5/21 (24%)
		leucine-rich repeat	271..293	CDD:275380	7/21 (33%)
		leucine-rich repeat	294..318	CDD:275380	8/23 (35%)
		leucine-rich repeat	319..339	CDD:275380	5/19 (26%)
		leucine-rich repeat	342..355	CDD:275378	4/12 (33%)
		gelsolin_S1_like	492..604	CDD:200446
		gelsolin_like	619..706	CDD:200436
		gelsolin_S3_like	723..837	CDD:200448
		gelsolin_like	<974..1034	CDD:200436
		gelsolin_S5_like	1053..1152	CDD:200444
		gelsolin_S6_like	1163..1289	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910